Species-Specific Transcriptional Activity of Synthetic Flavonoids in Guinea Pig and Mouse Cells as a Result of Differential Activation of the Aryl Hydrocarbon Receptor to Interact with Dioxin-Responsive Elements

2003 ◽  
Vol 63 (4) ◽  
pp. 915-924 ◽  
Author(s):  
Jun-guo Zhou ◽  
Ellen C. Henry ◽  
Christine M. Palermo ◽  
Stephen D. Dertinger ◽  
Thomas A. Gasiewicz
Keyword(s):  
Guinea Pig ◽  
Aryl Hydrocarbon Receptor ◽  
Transcriptional Activity ◽  
Differential Activation ◽  
Aryl Hydrocarbon ◽  
Mouse Cells ◽  
Species Specific

Differential activation of the aryl hydrocarbon receptor and regulation of differentiation in the epidermal equivalent model

Toxicology ◽  
2011 ◽  
Vol 290 (2-3) ◽  
pp. 137
Author(s):  
Alison R. Forrester ◽  
Penny E. Lovat ◽  
Mark Graham ◽  
Faith M. Williams ◽  
Nick J. Reynolds
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Equivalent Model ◽  
Differential Activation ◽  
Aryl Hydrocarbon

Interference with the uptake of guinea-pig agglutinins in mice due to fractions of papain hydrolyzed rabbit γ-globulin

1963 ◽  
Vol 157 (967) ◽  
pp. 160-169 ◽  
Keyword(s):  
Guinea Pig ◽  
Immune Serum ◽  
Rabbit Serum ◽  
Specific Receptor ◽  
Digestion Method ◽  
Suckling Mice ◽  
Absorptive Cells ◽  
Mouse Cells ◽  
Species Specific ◽  
To Receive

Antibodies from immune serum ingested by suckling mice and rats may enter into their circulations. The normal sera of certain species, when mixed with the immune serum administered, reduce the entry of antibodies. This effect was called interference. Interference with the uptake of guinea-pig agglutinins in mice due to rabbit serum and γ-globulin and to fragments I, II and III of rabbit γ-globulin, fractionated by the digestion method of Porter, is investigated. The effect of rabbit serum is due mostly, if not wholly, to its γ-globulin. Interference due to fragments I and II is negligible, whereas interference due to fragment III is at least 3.5 times greater than that due to the whole γ-globulin molecule. It is concluded that most of the configurations of the whole rabbit γ-globulin molecule which are recognized by mouse cells as heterologous are carried on fragment III. A hypothesis, which postulates a specific receptor within absorptive cells concerned with the transmission of antibodies across the gut of some young rodents, is discussed in the light of these results, when it is suggested that the receptor may be better adapted to receive the species-specific parts of antibody molecules rather than the residual or antibody reactive parts.

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