scholarly journals Cell-by-cell dissection of phloem development links a maturation gradient to cell specialization

Science ◽  
2021 ◽  
Vol 374 (6575) ◽  
Author(s):  
Pawel Roszak ◽  
Jung-ok Heo ◽  
Bernhard Blob ◽  
Koichi Toyokura ◽  
Yuki Sugiyama ◽  
...  
Keyword(s):  
Cell Specialization

Targeting circular RNA-Met for anti-angiogenesis treatment via inhibiting endothelial tip cell specialization

2022 ◽  
Author(s):  
Mu-Di Yao ◽  
Qin Jiang ◽  
Yan Ma ◽  
Yan Zhu ◽  
Qiu-Yang Zhang ◽  
...  
Keyword(s):  
Circular Rna ◽  
Tip Cell ◽  
Cell Specialization

scholarly journals Implications for Tumor Microenvironment and Epithelial Crosstalk in the Management of Gastrointestinal Cancers

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Yang Ge ◽  
C. Benedikt Westphalen ◽  
Wen Wee Ma ◽  
Kenneth J. Vega ◽  
Nathaniel Weygant
Keyword(s):  
Tumor Microenvironment ◽  
Cell Turnover ◽  
Gastrointestinal Cancers ◽  
Gi Tract ◽  
Immune Signaling ◽  
Gi Cancers ◽  
Cell Specialization

Rapid advances in technology are revealing previously unknown organization, cooperation, and limitations within the population of nontumor cells surrounding the tumor epithelium known as the tumor microenvironment (TME). Nowhere are these findings more pertinent than in the gastrointestinal (GI) tract where exquisite cell specialization supports a complex microenvironmental niche characterized by rapid stemness-associated cell turnover, pathogen sensing, epithelial orchestration of immune signaling, and other facets that maintain the complex balance between homeostasis, inflammation, and disease. Here, we summarize and discuss select emerging concepts in the precancerous microenvironment, TME, and tumor epithelial-TME crosstalk as well as their implications for the management of GI cancers.

A computational functional genomics based self-limiting self-concentration mechanism of cell specialization as a biological role of jumping genes

2016 ◽  
Vol 8 (1) ◽  
pp. 91-103 ◽  
Author(s):  
Jörn Lötsch ◽  
Alfred Ultsch
Keyword(s):  
Functional Genomics ◽  
Biological Role ◽  
Active Line ◽  
Jumping Genes ◽  
The Given ◽  
Over Time ◽  
Cell Specialization

LINE-1 retrotransposition may result in silencing of genes. This is more likely with genes not carrying active LINE-1 as those are about 10 times more frequent in the given set of genes. Over time this leads to self-specialization of the cell toward processes associated with gene carrying active LINE-1, which then functionally prevail in the chronified situation.

scholarly journals Common Features of Regulatory T Cell Specialization During Th1 Responses

2018 ◽  
Vol 9 ◽  
Author(s):  
Katharina Littringer ◽  
Claudia Moresi ◽  
Nikolas Rakebrandt ◽  
Xiaobei Zhou ◽  
Michelle Schorer ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Common Features ◽  
Cell Specialization

scholarly journals The retinal topography of three species of coleoid cephalopod: significance for perception of polarized light

2011 ◽  
Vol 366 (1565) ◽  
pp. 724-733 ◽  
Author(s):  
Christopher M. Talbot ◽  
Justin N. Marshall
Keyword(s):  
Cell Density ◽  
Polarized Light ◽  
Potential Significance ◽  
Retinal Topography ◽  
Habitat Differences ◽  
Light Stimuli ◽  
Structure Density ◽  
Horizontal Grid ◽  
Coleoid Cephalopod ◽  
Cell Specialization

The retinal topography of three species of coleoid cephalopod (one cuttlefish, one squid and one octopus) was investigated to examine and compare the structure, density and organization of the photoreceptors. The aim was to determine if there were areas of increased cell density and/or cell specialization that might be related to lifestyle or phylogeny. The orientation of photoreceptors around the curved surface of the retina was also mapped to reveal how the overall arrangement of cell microvilli might enable the perception of polarized light stimuli. It was found that all species possessed an increase in photoreceptor density in a horizontal streak approximately placed at the position of a potential horizon in the habitat. The overall arrangement of photoreceptor microvillar arrangements followed lines of latitude and longitude in a global projection that has been rotated by 90°. This arrangement seems to map polarization sensitivities on the outside world in a vertical and horizontal grid. The potential significance of this and other retinal specializations is discussed in the context of phylogenetic and habitat differences between species.

scholarly journals Cell Antigens and Cell Specialization. IV. On the H Blood Group Antigen of Human Platelets and Nucleated Cells of the Human Bone Marrow

Blood ◽  
1964 ◽  
Vol 24 (5) ◽  
pp. 531-541 ◽  
Author(s):  
EDMOND J. YUNIS ◽  
JORGE J. YUNIS
Keyword(s):  
Bone Marrow ◽  
Blood Group ◽  
Human Platelets ◽  
Blood Group Antigen ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Antigen Receptors ◽  
Cell Specialization

Abstract This article describes the specific agglutination of normoblasts, recitulocytes, megakaryocytes and platelets of human bone marrow with anti-H sera. It also describes the erythrocyte-platelet mixed agglutination reactions demonstrating H antigen receptors on all human platelets regardless of the ABO group of the donor with the exception of the Bombay blood.

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