scholarly journals Response to Comment on “Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression”

Science ◽  
2021 ◽  
Vol 372 (6538) ◽  
pp. eabf3316
Author(s):  
Sachiko Taniguchi ◽  
Ajit Elhance ◽  
Avery Van Duzer ◽  
Sushil Kumar ◽  
Justin Leitenberger ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cell ◽  
Cancer Progression ◽  
Squamous Cell ◽  
Immunoglobulin E ◽  
Marrow Cell ◽  
Squamous Cell Carcinomas ◽  
Nonspecific Binding ◽  
Tumor Initiating Cells ◽  
High Affinity

Kamphuis et al. argue that macrophages accumulated in the proximity of tumor-initiating cells do not express the high-affinity immunoglobulin E receptor FcεRIα. Although we cannot exclude the possibility of nonspecific binding of anti-FcεRIα antibody (clone MAR-1), we provide evidence that macrophages in squamous cell carcinomas express FcεRIα and that IL-33 induces FcεRIα expression in bone marrow cell–derived macrophages.

Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression

Science ◽  
2020 ◽  
Vol 369 (6501) ◽  
pp. eaay1813 ◽  
Author(s):  
Sachiko Taniguchi ◽  
Ajit Elhance ◽  
Avery Van Duzer ◽  
Sushil Kumar ◽  
Justin J. Leitenberger ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Transforming Growth Factor ◽  
Immunoglobulin E ◽  
Transforming Growth Factor Β ◽  
Drug Resistant ◽  
Tumor Initiating Cells ◽  
Interleukin 33 ◽  
High Affinity ◽  
Feedforward Loop ◽  
Close Proximity

Targeting the cross-talk between tumor-initiating cells (TICs) and the niche microenvironment is an attractive avenue for cancer therapy. We show here, using a mouse model of squamous cell carcinoma, that TICs play a crucial role in creating a niche microenvironment that is required for tumor progression and drug resistance. Antioxidant activity in TICs, mediated by the transcription factor NRF2, facilitates the release of a nuclear cytokine, interleukin-33 (IL-33). This cytokine promotes differentiation of macrophages that express the high-affinity immunoglobulin E receptor FcεRIα and are in close proximity to TICs. In turn, these IL-33–responding FcεRIα+ macrophages send paracrine transforming growth factor β (TGF-β) signals to TICs, inducing invasive and drug-resistant properties and further upregulating IL-33 expression. This TIC-driven, IL-33–TGF-β feedforward loop could potentially be exploited for cancer treatment.

scholarly journals INCORPORATION IN VITRO OF LABELED AMINO ACIDS INTO BONE MARROW CELL PROTEINS

1950 ◽  
Vol 186 (1) ◽  
pp. 297-307 ◽  
Author(s):  
Henry. Borsook ◽  
Clara L. Deasy ◽  
A.J. Haagen-Smit ◽  
Geoffrey. Keighley ◽  
Peter H. Lowy
Keyword(s):  
Amino Acids ◽  
Bone Marrow ◽  
Bone Marrow Cell ◽  
Marrow Cell
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