The Reemergence of Severe Group A Streptococcal Disease: an Evolutionary Perspective

2014 ◽  
pp. 93-123 ◽  
Author(s):  
Donald E. Low ◽  
Benjamin Schwartz ◽  
Allison McGeer
Keyword(s):  
Evolutionary Perspective ◽  
Streptococcal Disease ◽  
Severe Group ◽  
Group A

scholarly journals Strep-EURO: progress in analysis and research into severe streptococcal disease in Europe, 2003-2004

2005 ◽  
Vol 10 (5) ◽  
Author(s):  
A Jasir ◽  
C Schalén ◽  
Collective Strep-ERUO study group
Keyword(s):  
Streptococcal Disease ◽  
Severe Group ◽  
Group A

The Strep-EURO project collects data on severe group A streptococcal (GAS) disease in Europe.

scholarly journals Risk for Severe Group A Streptococcal Disease among Patients’ Household Contacts

2003 ◽  
Vol 9 (4) ◽  
pp. 443-447 ◽  
Author(s):  
Katherine A. Robinson ◽  
Gretchen Rothrock ◽  
Quyen Phan ◽  
Brenda Sayler ◽  
Karen Stefonek ◽  
...  
Keyword(s):  
Streptococcal Disease ◽  
Household Contacts ◽  
Severe Group ◽  
Group A

European surveillance of severe group A streptococcal disease

2002 ◽  
Vol 6 (35) ◽  
Author(s):  
C Schalén ◽  
Collective Strep-EURO
Keyword(s):  
Public Health ◽  
United Kingdom ◽  
Czech Republic ◽  
Invasive Disease ◽  
The Czech Republic ◽  
Surveillance Programme ◽  
Streptococcal Disease ◽  
The United Kingdom ◽  
Severe Group ◽  
Group A

Strep-EURO, a new European Commission Framework Five (QLK2-CT-2002-01398) surveillance programme for severe group A streptococcal disease (GAS), will be launched on 1 September 2002. The aim of the programme is to enhance understanding of the epidemiology of GAS invasive disease in Europe. Public health institutes from Sweden, Germany, the United Kingdom, the Czech Republic, Greece, Italy, Finland, Denmark, Romania, and Cyprus will participate.

scholarly journals Invasive Group A Streptococcal Disease in The Netherlands: Evidence for a Protective Role of Anti–Exotoxin A Antibodies

2000 ◽  
Vol 181 (2) ◽  
pp. 631-638 ◽  
Author(s):  
Ellen M. Mascini ◽  
Margriet Jansze ◽  
Joop F. P. Schellekens ◽  
James M. Musser ◽  
Joop A. J. Faber ◽  
...  
Keyword(s):  
The Netherlands ◽  
Protective Role ◽  
Exotoxin A ◽  
Invasive Group ◽  
Streptococcal Disease ◽  
Group A

Severe Group A Streptococcus Infection after Thyroidectomy: Report of Three Cases and Review

2008 ◽  
Vol 9 (5) ◽  
pp. 529-531 ◽  
Author(s):  
Frederic Faibis ◽  
David Sapir ◽  
David Luis ◽  
Patrice Laigneau ◽  
Agnes Lepoutre ◽  
...  
Keyword(s):  
Group A Streptococcus ◽  
Severe Group ◽  
Group A

DIAGNOSIS AND TREATMENT: GROUP A STREPTOCOCCAL INFECTIONS

PEDIATRICS ◽  
1965 ◽  
Vol 36 (6) ◽  
pp. 930-932
Author(s):  
Edward A. Mortimer ◽  
Bernard Boxerbaum
Keyword(s):  
Treatment Group ◽  
Oral Therapy ◽  
Accurate Diagnosis ◽  
Diagnosis And Treatment ◽  
Streptococcal Infections ◽  
Benzathine Penicillin ◽  
Throat Culture ◽  
Streptococcal Disease ◽  
Group A ◽  
And Control

In spite of adequate means of therapy, streptococcal disease and its complications continue to present problems to the physician who cares for children. For accurate diagnosis and control of streptococcal disease inexpensive bacteriologic culture facilities are required and the physician must assure himself of the accuracy of the results. To prevent the sequelae of streptococcal occal pharyngitis, therapy sufficient to eradicate the offending organism is required. Optimum therapy of streptococcal infections is intramuscular benzathine penicillin; oral therapy with penicillin or erythromycin should be followed by a throat culture to ensure that the streptococcus has been erdicated.

scholarly journals Host Pathways of Hemostasis that Regulate Group A Streptococcus pyogenes Pathogenicity

2020 ◽  
Vol 21 (2) ◽  
pp. 193-201
Author(s):  
Victoria A. Ploplis ◽  
Francis J. Castellino
Keyword(s):  
Streptococcus Pyogenes ◽  
Inflammatory Responses ◽  
Group A Streptococcus ◽  
Protein A ◽  
M Protein ◽  
Severe Group ◽  
Group A ◽  
Flow Through ◽  
Hallmark Feature ◽  
Major Target

A hallmark feature of severe Group A Streptococcus pyogenes (GAS) infection is dysregulated hemostasis. Hemostasis is the primary pathway for regulating blood flow through events that contribute towards clot formation and its dissolution. However, a number of studies have identified components of hemostasis in regulating survival and dissemination of GAS. Several proteins have been identified on the surface of GAS and they serve to either facilitate invasion to host distal sites or regulate inflammatory responses to the pathogen. GAS M-protein, a surface-exposed virulence factor, appears to be a major target for interactions with host hemostasis proteins. These interactions mediate biochemical events both on the surface of GAS and in the solution when M-protein is released into the surrounding environment through shedding or regulated proteolytic processes that dictate the fate of this pathogen. A thorough understanding of the mechanisms associated with these interactions could lead to novel approaches for altering the course of GAS pathogenicity.

High burden of invasive group A streptococcal disease in the Northern Territory of Australia

2015 ◽  
Vol 144 (5) ◽  
pp. 1018-1027 ◽  
Author(s):  
R. BOYD ◽  
M. PATEL ◽  
B. J. CURRIE ◽  
D. C. HOLT ◽  
T. HARRIS ◽  
...  
Keyword(s):  
Indigenous Population ◽  
Case Series ◽  
Northern Territory ◽  
Molecular Characteristics ◽  
Streptococcal Toxic Shock Syndrome ◽  
Public Health Response ◽  
Diverse Range ◽  
Invasive Group ◽  
Streptococcal Disease ◽  
Group A

SUMMARYAlthough the incidence of invasive group A streptococcal disease in northern Australia is very high, little is known of the regional epidemiology and molecular characteristics. We conducted a case series of Northern Territory residents reported between 2011 and 2013 withStreptococcus pyogenesisolates from a normally sterile site. Of the 128 reported episodes, the incidence was disproportionately high in the Indigenous population at 69·7/100 000 compared to 8·8/100 000 in the non-Indigenous population. Novel to the Northern Territory is the extremely high incidence in haemodialysis patients of 2205·9/100 000 population; and for whom targeted infection control measures could prevent transmission. The incidences in the tropical north and semi-arid Central Australian regions were similar. Case fatality was 8% (10/128) and streptococcal toxic shock syndrome occurred in 14 (11%) episodes. Molecular typing of 82 isolates identified 28emmtypes, of which 63 (77%) were represented by fouremmclusters. Typing confirmed transmission between infant twins. While the diverse range ofemmtypes presents a challenge for effective coverage by vaccine formulations, the limited number ofemmclusters raises optimism should cluster-specific cross-protection prove efficacious. Further studies are required to determine effectiveness of chemoprophylaxis for contacts and to inform public health response.

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