Both Fidaxomicin and Vancomycin Inhibit Outgrowth of Clostridium difficile Spores
2012 ◽
Vol 57
(1)
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pp. 664-667
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Keyword(s):
ABSTRACTFidaxomicin (FDX) is approved to treatClostridium difficile-associated diarrhea and is superior to vancomycin in providing a sustained clinical response (cure without recurrence in the subsequent 25 days). The mechanism(s) behind the low recurrence rate of FDX-treated patients could be multifactorial. Here, we tested effects of FDX, its metabolite OP-1118, and vancomycin on spore germination and determined that none affected the initiation of spore germination but all inhibited outgrowth of vegetative cells from germinated spores.
2016 ◽
Vol 65
(2)
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pp. 169-175
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Keyword(s):
Keyword(s):
2011 ◽
Vol 55
(9)
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pp. 4427-4429
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Keyword(s):
Keyword(s):