Characterization of In100, a New Integron Carrying a Metallo-β-Lactamase and a Carbenicillinase, from Pseudomonas aeruginosa

ABSTRACT In100, a new integron carrying a carbapenemase gene (bla VIM-2) associated with a carbenicillinase (blaP1b) and aminoglycoside resistance genes (aacA4 and aadA2), was detected in a Pseudomonas aeruginosa clinical isolate. The particular gene cassette organization of In100 seems to reflect the evolution of antibiotic usage in therapeutics.

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In99, an In100-related integron, its occurrence and prevalence in clinical Pseudomonas aeruginosa strains from a central region of Portugal

Epidemiology and Infection ◽

10.1017/s095026880600700x ◽

2006 ◽

Vol 135 (3) ◽

pp. 502-504 ◽

Cited By ~ 3

Author(s):

T. CAETANO ◽

S. FERREIRA ◽

A. P. MONDEGO ◽

A. CORREIA ◽

S. MENDO

Keyword(s):

Pseudomonas Aeruginosa ◽

Resistance Genes ◽

Central Region ◽

Clinical Isolates ◽

Aminoglycoside Resistance ◽

Class 1 Integron ◽

Class 1 ◽

Aminoglycoside Resistance Genes

In99, a possible ancestor of In100, is a class 1 integron associated with carbenicillinase (blaPSE) and aminoglycoside resistance genes [aac(6′)-Ib and aadA2]. In99 was present in 8 of 81 clinical isolates of Pseudomonas aeruginosa from unrelated patients collected in different years. The strains fell into two clonal groups and exhibited resistance to β-lactams and aminoglycosides.

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blaOXA-10,efflux pump and aminoglycoside resistance genes in Pseudomonas aeruginosa from Nigeria

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2014.03.624 ◽

2014 ◽

Vol 21 ◽

pp. 94

Author(s):

B.T. Odumosu ◽

B.A. Adeniyi ◽

R. Chandra

Keyword(s):

Pseudomonas Aeruginosa ◽

Resistance Genes ◽

Efflux Pump ◽

Aminoglycoside Resistance ◽

Aminoglycoside Resistance Genes

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Prevalence and Characterization of Apramycin-Resistant Salmonella enterica Serotype Typhimurium Isolated from Healthy and Diseased Pigs in Korea during 1998 through 2009

Journal of Food Protection ◽

10.4315/0362-028x.jfp-13-069 ◽

2013 ◽

Vol 76 (8) ◽

pp. 1443-1446 ◽

Cited By ~ 1

Author(s):

SUK-KYUNG LIM ◽

HYANG-MI NAM ◽

HEE-SOO LEE ◽

AE-RAN KIM ◽

GUM-CHAN JANG ◽

...

Keyword(s):

Public Health ◽

Salmonella Typhimurium ◽

Resistance Genes ◽

Salmonella Enterica ◽

Cross Resistance ◽

Aminoglycoside Resistance ◽

Disease Treatment ◽

Phage Types ◽

Aminoglycoside Resistance Genes

Apramycin resistance was observed in 22.8% (81 of 355) of Salmonella Typhimurium isolates collected from pigs from 1998 through 2009 in Korea. All apramycin-resistant Salmonella Typhimurium isolates also were cross-resistant to gentamicin and tobramycin. Among the seven types of aminoglycoside resistance genes tested, only four types were detected in the apramycin-resistant Salmonella Typhimurium isolates: aac (3)-IV, aac (3)-II, aac (3)-III, and ant (2″)-I. Although the aac (3)-IV gene was found in all apramycin-resistant Salmonella Typhimurium isolates, aac (3)-II, aac (3)-III, and ant (2″)-I genes were detected in five (6.2%), two (2.5%), and three (3.7%) isolates, respectively. The apramycin-resistant isolates comprised six phage types, of which PT193 (16 of 81 isolates, 19.8%) was most commonly observed. To our knowledge, this is the first report describing characteristics of apramycin-resistant Salmonella Typhimurium isolates in Korea. Further study is warranted to determine whether apramycin use in animals results in cross-resistance to gentamicin, which may affect public health when gentamicin is required for disease treatment in humans.

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