Role of Malic Enzyme during Fatty Acid Synthesis in the Oleaginous Fungus Mortierella alpina

The effect of varying dietary levels of maize oil and tripalmitin (0–250 g fat/kg) on hepatic lipogenesis and the levels of hepatic fatty acid synthetase (FAS), glucose-6-phosphate dehydrogenase (EC 1.1.1.49; G6PD), malic enzyme (EC 1.1.1.38, 1.1.1.39, 1.1.1.40; ME) and glucokinase (EC 2.7.1.2; GK) was examined in meal-fed mice.2. Meal-fed mice compared to mice fed ad lib. show enhanced hepatic lipogenesis as demonstrated by an increased rate of in vivo fatty acid synthesis and increased levels of FAS, ME and G6PD. The level of GK in meal-fed mice was unchanged by meal feeding.3. Maize oil more effectively reduced in vivo hepatic lipogenesis than tripalmitin in meal-fed mice.4. Maize oil more effectively reduced the hepatic levels of FAS, G6PD, ME and GK than tripalmitin in meal-fed mice.5. The increased inhibition by maize oil is observed at all levels of fat in the diet investigated and has been shown not to be due to decreased carbohydrate intake nor to differences between the absorption of maize oil and tripalmitin.

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Fatty acid synthesis by isolated leucoplasts from developingBrassica seeds: Role of nucleoside triphosphates and DHAP-shuttle as the source of energy

Journal of Biosciences ◽

10.1007/bf02704723 ◽

1996 ◽

Vol 21 (6) ◽

pp. 819-826 ◽

Cited By ~ 3

Author(s):

Ranjan Gupta ◽

Randhir Singh

Keyword(s):

Fatty Acid ◽

Fatty Acid Synthesis ◽

Acid Synthesis ◽

Nucleoside Triphosphates

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The Role of Carnitine in Acetoacetate Production and Fatty Acid Synthesis*

Journal of Clinical Investigation ◽

10.1172/jci105196 ◽

1965 ◽

Vol 44 (5) ◽

pp. 840-848 ◽

Cited By ~ 16

Author(s):

Rubin Bressler ◽

Richard I. Katz

Keyword(s):

Fatty Acid ◽

Fatty Acid Synthesis ◽

Acid Synthesis

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Lipid Metabolism in Development and Progression of Hepatocellular Carcinoma

Cancers ◽

10.3390/cancers12061419 ◽

2020 ◽

Vol 12 (6) ◽

pp. 1419 ◽

Cited By ~ 3

Author(s):

Moris Sangineto ◽

Rosanna Villani ◽

Francesco Cavallone ◽

Antonino Romano ◽

Domenico Loizzi ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Fatty Acid ◽

Lipid Metabolism ◽

Fatty Acid Synthesis ◽

Cell Signalling ◽

Acid Synthesis ◽

Environmental Adaptation ◽

Metabolic Reprogramming ◽

Therapeutic Approaches

Metabolic reprogramming is critically involved in the development and progression of cancer. In particular, lipid metabolism has been investigated as a source of energy, micro-environmental adaptation, and cell signalling in neoplastic cells. However, the specific role of lipid metabolism dysregulation in hepatocellular carcinoma (HCC) has not been widely described yet. Alterations in fatty acid synthesis, β-oxidation, and cellular lipidic composition contribute to initiation and progression of HCC. The aim of this review is to elucidate the mechanisms by which lipid metabolism is involved in hepatocarcinogenesis and tumour adaptation to different conditions, focusing on the transcriptional aberrations with new insights in lipidomics and lipid zonation. This will help detect new putative therapeutic approaches in the second most frequent cause of cancer-related death.

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