Comparison of Intranasal and Intramuscular Immunization against Human Immunodeficiency Virus Type 1 with a DNA-Monophosphoryl Lipid A Adjuvant Vaccine
1998 ◽
Vol 66
(2)
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pp. 823-826
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Keyword(s):
Lipid A
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ABSTRACT We compared immune responses to intranasal and intramuscular DNA vaccinations against human immunodeficiency virus type 1 with monophosphoryl lipid A (MPL) used as an adjuvant. Both routes of vaccination resulted in similar levels of cell-mediated immunity, but the intestinal secretory immunoglobulin A response was higher following intranasal immunization than after intramuscular immunization. MPL demonstrated its adjuvanticity in vaccination by both routes.
1997 ◽
Vol 65
(9)
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pp. 3520-3528
◽
2008 ◽
Vol 2008
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pp. 351-352
1993 ◽
Vol 129
(12)
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pp. 1620-1622
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2003 ◽
Vol 22
(4)
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pp. 281-286
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