Function of the Fibronectin-Binding Serum Opacity Factor of Streptococcus pyogenes in Adherence to Epithelial Cells
2004 ◽
Vol 72
(7)
◽
pp. 4302-4308
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Keyword(s):
ABSTRACT The serum opacity factor (SOF) of Streptococcus pyogenes is a serotyping tool and pathogenesis factor. Using SOF-coated latex beads in cell adherence assays and antiserum directed against SOF in S. pyogenes-HEp-2 cell adherence inhibition experiments, we demonstrate SOF involvement in the fibronectin-mediated adherence of S. pyogenes to epithelial cells. SOF exclusively targets the 30-kDa N-terminal region of fibronectin. The interaction revealed association and dissociation constants 1 order of magnitude lower than those of other S. pyogenes fibronectin-binding proteins.
2002 ◽
Vol 70
(7)
◽
pp. 3865-3873
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2008 ◽
Vol 42
(1)
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pp. 75-86
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1997 ◽
Vol 65
(4)
◽
pp. 1357-1363
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1992 ◽
Vol 60
(9)
◽
pp. 3837-3844
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1990 ◽
Vol 258
(6)
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pp. C1036-C1043
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Keyword(s):
1999 ◽
Vol 32
(1)
◽
pp. 89-98
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2020 ◽
pp. 181-190
Keyword(s):