scholarly journals Diffusible Signal Factor-Dependent Cell-Cell Signaling and Virulence in the Nosocomial Pathogen Stenotrophomonas maltophilia

2007 ◽  
Vol 189 (13) ◽  
pp. 4964-4968 ◽  
Author(s):  
Yvonne Fouhy ◽  
Karl Scanlon ◽  
Katherine Schouest ◽  
Charles Spillane ◽  
Lisa Crossman ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Cell Signaling ◽  
Stenotrophomonas Maltophilia ◽  
Xanthomonas Campestris ◽  
Signaling System ◽  
Nosocomial Pathogen ◽  
Diffusible Signal Factor ◽  
Dependent Cell ◽  
A Cell ◽  
Cell Cell

ABSTRACT The genome of Stenotrophomonas maltophilia encodes a cell-cell signaling system that is highly related to the diffusible signal factor (DSF)-dependent system of the phytopathogen Xanthomonas campestris. Here we show that in S. maltophilia, DSF signaling controls factors contributing to the virulence and antibiotic resistance of this important nosocomial pathogen.

scholarly journals The Ax21 Protein Is a Cell-Cell Signal That Regulates Virulence in the Nosocomial Pathogen Stenotrophomonas maltophilia

2011 ◽  
Vol 193 (22) ◽  
pp. 6375-6378 ◽  
Author(s):  
Yvonne McCarthy ◽  
J. Maxwell Dow ◽  
Robert P. Ryan
Keyword(s):  
Stenotrophomonas Maltophilia ◽  
Xanthomonas Oryzae ◽  
Nosocomial Pathogen ◽  
Diverse Range ◽  
Content Type ◽  
Cell Signal ◽  
Range Of Functions ◽  
A Cell ◽  
Cell Cell

Stenotrophomonas maltophilia encodes proteins related to the Rax proteins of Xanthomonas oryzae , which are required for the synthesis and secretion of the Ax21 protein. Here we show that Ax21 acts as a cell-cell signal to regulate a diverse range of functions, including virulence, in this nosocomial pathogen.

C-factor: A cell-cell signaling protein required for fruiting body morphogenesis of M. Xanthus

Cell ◽  
1990 ◽  
Vol 61 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Seung K. Kim ◽  
Dale Kaiser
Keyword(s):  
Cell Signaling ◽  
Fruiting Body ◽  
Signaling Protein ◽  
A Cell ◽  
Cell Cell

scholarly journals The Ax21 protein influences virulence and biofilm formation in the nosocomial pathogen Stenotrophomonas maltophilia

2017 ◽  
Author(s):  
Shi-qi An ◽  
Ji-liang Tang
Keyword(s):  
Antibiotic Resistance ◽  
Plant Pathogen ◽  
Biofilm Formation ◽  
Stenotrophomonas Maltophilia ◽  
Xanthomonas Oryzae ◽  
Nosocomial Pathogen ◽  
Antibiotic Resistant ◽  
Gram Negative ◽  
Hospital Acquired Infection ◽  
Hospital Acquired

Stenotrophomonas maltophilia is an antibiotic resistant Gram-negative pathogen, which is associated with hospital-acquired infection. The genome encodes a protein highly related to the Ax21 protein of Xanthomonas oryzae pv. oryzae that is implicated in interactions of this plant pathogen with rice. Here we show that loss by mutation of Ax21 influences a variety of functions in Stenotrophomonas maltophilia, to include virulence, antibiotic resistance and biofilm formation in this nosocomial pathogen.

scholarly journals Vascular Endothelial-Cadherin Stabilizes at Cell–Cell Junctions by Anchoring to Circumferential Actin Bundles through α- and β-Catenins in Cyclic AMP-Epac-Rap1 Signal-activated Endothelial Cells

2010 ◽  
Vol 21 (4) ◽  
pp. 584-596 ◽  
Author(s):  
Kazuomi Noda ◽  
Jianghui Zhang ◽  
Shigetomo Fukuhara ◽  
Satoshi Kunimoto ◽  
Michihiro Yoshimura ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Classical Model ◽  
Green Fluorescence Protein ◽  
Cell Junctions ◽  
Vascular Endothelial ◽  
Cell Contacts ◽  
Actin Bundles ◽  
Dependent Cell ◽  
A Cell ◽  
Cell Cell

Vascular endothelial (VE)-cadherin is a cell–cell adhesion molecule involved in endothelial barrier functions. Previously, we reported that cAMP-Epac-Rap1 signal enhances VE-cadherin–dependent cell adhesion. Here, we further scrutinized how cAMP-Epac-Rap1 pathway promotes stabilization of VE-cadherin at the cell–cell contacts. Forskolin induced circumferential actin bundling and accumulation of VE-cadherin fused with green fluorescence protein (VEC-GFP) on the bundled actin filaments. Fluorescence recovery after photobleaching (FRAP) analyses using VEC-GFP revealed that forskolin stabilizes VE-cadherin at cell–cell contacts. These effects of forskolin were mimicked by an activator for Epac but not by that for protein kinase A. Forskolin-induced both accumulation and stabilization of junctional VEC-GFP was impeded by latrunculin A. VE-cadherin, α-catenin, and β-catenin were dispensable for forskolin-induced circumferential actin bundling, indicating that homophilic VE-cadherin association is not the trigger of actin bundling. Requirement of α- and β-catenins for forskolin-induced stabilization of VE-cadherin on the actin bundles was confirmed by FRAP analyses using VEC-GFP mutants, supporting the classical model that α-catenin could potentially link the bundled actin to cadherin. Collectively, circumferential actin bundle formation and subsequent linkage between actin bundles and VE-cadherin through α- and β-catenins are important for the stabilization of VE-cadherin at the cell–cell contacts in cAMP-Epac-Rap1 signal-activated cells.

scholarly journals Diffusible Signal Factor signaling regulates multiple functions in the opportunistic pathogen Stenotrophomonas maltophilia

2018 ◽  
Author(s):  
Shi-qi An ◽  
Ji-liang Tang
Keyword(s):  
Nosocomial Infections ◽  
Biofilm Formation ◽  
Stenotrophomonas Maltophilia ◽  
Opportunistic Pathogen ◽  
Negative Bacterium ◽  
Signaling Mechanism ◽  
Gram Negative ◽  
Multiple Functions ◽  
Diffusible Signal Factor ◽  
Dependent Cell

AbstractStenotrophomonas maltophilia is a Gram-negative bacterium commonly isolated from nosocomial infections. Analysis of the genome of the clinical Stenotrophomonas maltophilia isolate K279a indicates that it encodes a diffusible signal factor (DSF)-dependent cell-cell signaling mechanism that is highly similar to the system previously described in phytopathogens from the genera Xanthomonas and Xylella. Here we demonstrate that in S. maltophilia strain K279a, DSF signaling regulates factors contributing to virulence, biofilm formation and motility of this important opportunistic pathogen.

Interference of Cranberry Constituents in Cell–Cell Signaling System of Vibrio harveyi

2009 ◽  
Vol 59 (4) ◽  
pp. 469-474 ◽  
Author(s):  
Mark Feldman ◽  
Ervin I. Weiss ◽  
Itzhak Ofek ◽  
Doron Steinberg
Keyword(s):  
Cell Signaling ◽  
Vibrio Harveyi ◽  
Signaling System ◽  
Cell Cell

scholarly journals Cell-cell signaling in Xanthomonas campestris involves an HD-GYP domain protein that functions in cyclic di-GMP turnover

2006 ◽  
Vol 103 (17) ◽  
pp. 6712-6717 ◽  
Author(s):  
R. P. Ryan ◽  
Y. Fouhy ◽  
J. F. Lucey ◽  
L. C. Crossman ◽  
S. Spiro ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Xanthomonas Campestris ◽  
Domain Protein ◽  
Cell Cell
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