scholarly journals The U24 Protein from Human Herpesvirus 6 and 7 Affects Endocytic Recycling

2009 ◽  
Vol 84 (3) ◽  
pp. 1265-1275 ◽  
Author(s):  
Brian M. Sullivan ◽  
Laurent Coscoy
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Human Herpesvirus ◽  
Cell Receptor ◽  
Receptor Expression ◽  
Membrane Insertion ◽  
Human Herpesvirus 6 ◽  
Endosomal Recycling ◽  
Endosomal Transport ◽  
Basic Cellular Process

ABSTRACT Modulation of T-cell receptor expression and signaling is essential to the survival of many viruses. The U24 protein expressed by human herpesvirus 6A, a ubiquitous human pathogen, has been previously shown to downregulate the T-cell receptor. Here, we show that U24 also mediates cell surface downregulation of a canonical early endosomal recycling receptor, the transferrin receptor, indicating that this viral protein acts by blocking early endosomal recycling. We present evidence that U24 is a C-tail-anchored protein that is dependent for its function on TRC40/Asna-1, a component of a posttranslational membrane insertion pathway. Finally, we find that U24 proteins from other roseoloviruses have a similar genetic organization and a conserved function that is dependent on a proline-rich motif. Inhibition of a basic cellular process by U24 has interesting implications not only for the pathogenicity of roseoloviruses but also for our understanding of the biology of endosomal transport.

scholarly journals Downregulation of the T-Cell Receptor Complex and Impairment of T-Cell Activation by Human Herpesvirus 6 U24 Protein

2007 ◽  
Vol 82 (2) ◽  
pp. 602-608 ◽  
Author(s):  
Brian M. Sullivan ◽  
Laurent Coscoy
Keyword(s):  
T Cell ◽  
Cell Surface ◽  
T Cell Receptor ◽  
T Cell Activation ◽  
Cell Activation ◽  
Human Herpesvirus ◽  
Cell Receptor ◽  
Immune Recognition ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6

ABSTRACT We have performed a screen aimed at identifying human herpesvirus 6 (HHV-6)-encoded proteins that modulate immune recognition. Here we show that the U24 protein encoded by HHV-6 variant A downregulates cell surface expression of the T-cell receptor (TCR)/CD3 complex, a complex essential to T-cell activation and the generation of an immune adaptive response. In the presence of U24, the TCR/CD3 complex is endocytosed but is not recycled back to the plasma membrane. Instead, it accumulates in early and late endosomes. Interestingly, whereas CD3 downregulation from the cell surface is normally associated with T-cell activation, U24 downregulates CD3 independently of T-cell activation. Moreover, we found that U24-expressing T cells are resistant to activation by antigen-presenting cells. HHV-6 has evolved a unique mechanism of inhibition of T-cell activation that may impair the establishment of an adaptive immune response. Furthermore, lymphocyte activation creates an environment favorable to the reactivation and replication of lymphotropic herpesviruses. Thus, by inhibiting T-cell activation, HHV-6 might limit its reactivation and thus minimize immune recognition.

Analysis of Function, Specificity and T Cell Receptor Expression of Cloned Mucosal T Cell Lines in Crohn's Disease

1996 ◽  
Vol 9 (2) ◽  
pp. 193-204 ◽  
Author(s):  
Thomas P. Prindiville ◽  
Mary C. Cantrell ◽  
Takayuki Matsumoto ◽  
William R. Brown ◽  
Aftab A. Ansari ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
T Cell ◽  
Crohn's Disease ◽  
T Cell Receptor ◽  
Cell Lines ◽  
Cell Receptor ◽  
Receptor Expression ◽  
T Cell Lines ◽  
Analysis Of Function

Cell Biology of T Cell Receptor Expression and Regulation

2018 ◽  
Vol 36 (1) ◽  
pp. 103-125 ◽  
Author(s):  
Andrés Alcover ◽  
Balbino Alarcón ◽  
Vincenzo Di Bartolo
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Biology ◽  
Cell Receptor ◽  
Receptor Expression

scholarly journals T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation

Immunity ◽  
2018 ◽  
Vol 48 (4) ◽  
pp. 745-759.e6 ◽  
Author(s):  
Eric Tu ◽  
Cheryl P.Z. Chia ◽  
Weiwei Chen ◽  
Dunfang Zhang ◽  
Sang A. Park ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Receptor Expression ◽  
Type I ◽  
Cell Quiescence

5.6 T-cell receptor expression in patients with rheumatic diseases

1992 ◽  
Vol 26 (1-4) ◽  
pp. 218-222 ◽  
Author(s):  
F. De Keyser ◽  
D. Benoit ◽  
D. Elewaut ◽  
B. Leroy ◽  
A.M. Malfait ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Rheumatic Diseases ◽  
Cell Receptor ◽  
Receptor Expression

Flow Cytometric Detection of Neoplastic T Cells in Patients with Mycosis Fungoides Based on Levels of T-Cell Receptor Expression

1994 ◽  
Vol 102 (6) ◽  
pp. 856-860 ◽  
Author(s):  
Miroslaw Kuchnio ◽  
Edward A. Sausville ◽  
Elaine S. Jaffe ◽  
Timothy Greiner ◽  
Francine M. Foss ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Mycosis Fungoides ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Receptor Expression ◽  
Flow Cytometric
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