scholarly journals A Detrimental Effect of Interleukin-10 on Protective Pulmonary Humoral Immunity during Primary Influenza A Virus Infection

2010 ◽  
Vol 84 (10) ◽  
pp. 5007-5014 ◽  
Author(s):  
Keer Sun ◽  
Luisa Torres ◽  
Dennis W. Metzger
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Interleukin 10 ◽  
Viral Clearance ◽  
Wild Type ◽  
Passive Protection ◽  
Virus Specific Antibody ◽  
Influenza A Virus Infection

ABSTRACT Interleukin-10 (IL-10) is an important anti-inflammatory molecule that can cause immunosuppression and long-term pathogen persistence during chronic infection of mice with viruses such as lymphocytic choriomeningitis virus. However, its specific role in immunity to acute viral infections is not fully understood. We found that IL-10 plays a detrimental role in host responses to acute influenza A virus since IL-10−/− mice had improved viral clearance and survival after infection compared to wild-type mice. Enhanced viral clearance in IL-10−/− mice was not correlated with increased CD4+ or CD8+ T-cell recruitment into the lung but was correlated with increased pulmonary anti-influenza virus antibody titers, and this was dependent upon the presence of T cells, primarily CD4+ T cells. In addition, virus-specific antibody produced during the early stages of infection in the respiratory tract of IL-10−/− but not wild-type mice was sufficient to mediate passive protection against viral challenge of naïve mice. Complement was necessary for this antibody-mediated passive protection, but FcγR or neutrophil deficiency did not significantly influence viral clearance. Our results show that an absence of IL-10 at the time of primary infection leads to enhanced local virus-specific antibody production and, thus, increased protection against influenza A virus infection.

scholarly journals Memory regulatory T cells home to the lung and control influenza A virus infection

2019 ◽  
Vol 97 (9) ◽  
pp. 774-786 ◽  
Author(s):  
Chunni Lu ◽  
Damien Zanker ◽  
Peter Lock ◽  
Xiangrui Jiang ◽  
Jieru Deng ◽  
...  
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Regulatory T Cells ◽  
Influenza A Virus ◽  
Influenza A ◽  
Influenza A Virus Infection ◽  
And Control

scholarly journals Type I Interferon Plays Opposing Roles in Cytotoxicity and Interferon-γ Production by Natural Killer and CD8+ T Cells after Influenza A Virus Infection in Mice

2014 ◽  
Vol 6 (4) ◽  
pp. 456-466 ◽  
Author(s):  
Yojiro Arimori ◽  
Risa Nakamura ◽  
Hisakata Yamada ◽  
Kensuke Shibata ◽  
Naoyoshi Maeda ◽  
...  
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Natural Killer ◽  
Influenza A Virus ◽  
Influenza A ◽  
Type I Interferon ◽  
Type I ◽  
Influenza A Virus Infection

scholarly journals CD83 Expression Regulates Antibody Production in Response to Influenza A Virus Infection

2020 ◽  
Author(s):  
Madhav Akauliya ◽  
Avishekh Gautam ◽  
Sony Maharjan ◽  
Byoung Kwon Park ◽  
Jinsoo Kim ◽  
...  
Keyword(s):  
Bone Marrow ◽  
B Cells ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Cell Population ◽  
Peritoneal Cavity ◽  
Antibody Production ◽  
Influenza A ◽  
Wild Type ◽  
Influenza A Virus Infection

Abstract Background: CD83 is known to regulate lymphocyte maturation, activation, homeostasis, and antibody response to immunization and infection. While CD83 has a major part in B cell function, its role in influenza A virus infection has not yet been investigated. Methods: We investigated the role of CD83 using C57BL/6J wild type mice and CD83 knockout (KO) mice after intraperitoneal administration of the influenza A/WSN/1933 virus. We analyzed cells of the peritoneal cavity, splenocytes, and cells of the bone marrow with FACS to investigate CD83 expression and cell population change in response to the virus infection. ELISA was performed with sera and peritoneal cavity fluids to detect A/WSN/1933 virus-specific IgG and the subclasses of IgG. Results: FACS analysis data showed a transient but distinct induction of CD83 expression in the peritoneal B cells of wild type mice. CD83 KO mice exhibited a delayed recovery of B cells in the bone marrow after influenza virus infection and overall, a smaller T cell population compared to wild type mice. The peritoneal cavity and serum of the wild type mice contained a high titer of IgG within 14 days after infection, whereas the CD83 KO mice had a very low titer of IgG. Conclusions: These results show the importance of CD83 in lymphocytes homeostasis and antibody production during influenza A virus infection.

scholarly journals Cutting Edge: Antigen Presentation to CD8 T Cells after Influenza A Virus Infection

2008 ◽  
Vol 182 (1) ◽  
pp. 29-33 ◽  
Author(s):  
Elizabeth Ingulli ◽  
Castle Funatake ◽  
Erica L. Jacovetty ◽  
Maurizio Zanetti
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Antigen Presentation ◽  
Influenza A Virus ◽  
Cd8 T Cells ◽  
Influenza A ◽  
Cutting Edge ◽  
Influenza A Virus Infection

High Levels of Virus-Specific CD4+T Cells Predict Severe Pandemic Influenza A Virus Infection

2012 ◽  
Vol 186 (12) ◽  
pp. 1292-1297 ◽  
Author(s):  
Yan Zhao ◽  
Yong-Hong Zhang ◽  
Laura Denney ◽  
Duncan Young ◽  
Tim J. Powell ◽  
...  
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Pandemic Influenza ◽  
Cd4 T Cells ◽  
Influenza A ◽  
Influenza A Virus Infection

scholarly journals Highly Pathological Influenza A Virus Infection Is Associated with Augmented Expression of PD-1 by Functionally Compromised Virus-Specific CD8+ T Cells

2013 ◽  
Vol 88 (3) ◽  
pp. 1636-1651 ◽  
Author(s):  
J. A. Rutigliano ◽  
S. Sharma ◽  
M. Y. Morris ◽  
T. H. Oguin ◽  
J. L. McClaren ◽  
...  
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Cd8 T Cells ◽  
Influenza A ◽  
Influenza A Virus Infection

scholarly journals CD83 expression regulates antibody production in response to influenza A virus infection

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Madhav Akauliya ◽  
Avishekh Gautam ◽  
Sony Maharjan ◽  
Byoung Kwon Park ◽  
Jinsoo Kim ◽  
...  
Keyword(s):  
Bone Marrow ◽  
B Cells ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Cell Population ◽  
Peritoneal Cavity ◽  
Antibody Production ◽  
Influenza A ◽  
Wild Type ◽  
Influenza A Virus Infection

Abstract Background CD83 is known to regulate lymphocyte maturation, activation, homeostasis, and antibody response to immunization and infection. While CD83 has a major part in B cell function, its role in influenza A virus infection has not yet been investigated. Methods We investigated the role of CD83 using C57BL/6J wild type mice and CD83 knockout (KO) mice after intraperitoneal administration of the influenza A/WSN/1933 virus. We analyzed cells of the peritoneal cavity, splenocytes, and cells of the bone marrow with FACS to investigate CD83 expression and cell population change in response to the virus infection. ELISA was performed with sera and peritoneal cavity fluids to detect A/WSN/1933 virus-specific IgG and the subclasses of IgG. Results FACS analysis data showed a transient but distinct induction of CD83 expression in the peritoneal B cells of wild type mice. CD83 KO mice exhibited a delayed recovery of B cells in the bone marrow after influenza virus infection and overall, a smaller T cell population compared to wild type mice. The peritoneal cavity and serum of the wild type mice contained a high titer of IgG within 14 days after infection, whereas the CD83 KO mice had a very low titer of IgG. Conclusions These results show the importance of CD83 in lymphocytes homeostasis and antibody production during influenza A virus infection.

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