scholarly journals Activation of Peripheral Blood Mononuclear Cells by Dengue Virus Infection Depotentiates Balapiravir

2013 ◽  
Vol 88 (3) ◽  
pp. 1740-1747 ◽  
Author(s):  
Y.-L. Chen ◽  
N. Abdul Ghafar ◽  
R. Karuna ◽  
Y. Fu ◽  
S. P. Lim ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Dengue Virus Infection ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

Lymphotropic Virus Infection of Peripheral Blood Mononuclear Cells in B-Cell Non-Hodgkin’s Lymphoma

1997 ◽  
Vol 98 (2) ◽  
pp. 89-94 ◽  
Author(s):  
Clodoveo Ferri ◽  
Francesca Lo Jacono ◽  
Monica Monti ◽  
Francesco Caracciolo ◽  
Luca La Civita ◽  
...  
Keyword(s):  
Virus Infection ◽  
B Cell ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Hodgkin’S Lymphoma ◽  
Mononuclear Cells ◽  
Hodgkin's Lymphoma ◽  
Peripheral Blood Mononuclear ◽  
Non Hodgkin's Lymphoma ◽  
Blood Mononuclear Cells

scholarly journals Predominance of HLA-Restricted Cytotoxic T-Lymphocyte Responses to Serotype-Cross-Reactive Epitopes on Nonstructural Proteins following Natural Secondary Dengue Virus Infection

1998 ◽  
Vol 72 (5) ◽  
pp. 3999-4004 ◽  
Author(s):  
Anuja Mathew ◽  
Ichiro Kurane ◽  
Sharone Green ◽  
Henry A. F. Stephens ◽  
David W. Vaughn ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
T Lymphocyte ◽  
Mononuclear Cells ◽  
Cytotoxic T Lymphocyte ◽  
Nonstructural Proteins ◽  
Dengue Virus Infection ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells ◽  
Lymphocyte Responses

ABSTRACT We examined the memory cytotoxic T-lymphocytic (CTL) responses of peripheral blood mononuclear cells (PBMC) obtained from patients in Thailand 12 months after natural symptomatic secondary dengue virus infection. In all four patients analyzed, CTLs were detected in bulk culture PBMC against nonstructural dengue virus proteins. Numerous CD4+ and CD8+ CTL lines were generated from the bulk cultures of two patients, KPP94-037 and KPP94-024, which were specific for NS1.2a (NS1 and NS2a collectively) and NS3 proteins, respectively. All CTL lines derived from both patients were cross-reactive with other serotypes of dengue virus. The CD8+ NS1.2a-specific lines from patient KPP94-037 were HLA B57 restricted, and the CD8+ NS3-specific lines from patient KPP94-024 were HLA B7 restricted. The CD4+ CTL lines from patient KPP94-037 were HLA DR7 restricted. A majority of the CD8+ CTLs isolated from patient KPP94-024 were found to recognize amino acids 221 to 232 on NS3. These results demonstrate that in Thai patients after symptomatic secondary natural dengue infections, CTLs are mainly directed against nonstructural proteins and are broadly cross-reactive.

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