scholarly journals Analysis of Assembly and Budding of Lujo Virus

2015 ◽  
Vol 90 (6) ◽  
pp. 3257-3261 ◽  
Author(s):  
Shuzo Urata ◽  
Jacqueline Weyer ◽  
Nadia Storm ◽  
Yukiko Miyazaki ◽  
Petrus Jansen van Vuren ◽  
...  

The recently identified arenavirus Lujo virus (LUJV) causes fatal hemorrhagic fever in humans. We analyzed its mechanism of viral release driven by matrix protein Z and the cell surface glycoprotein precursor GPC. The L domains in Z are required for efficient virus-like particle release, but Tsg101, ALIX/AIP1, and Vps4A/B are unnecessary for budding. LUJV GPC is cleaved by site 1 protease (S1P) at the RKLM motif, and treatment with the S1P inhibitor PF-429242 reduced LUJV production.

1995 ◽  
Vol 62 (5) ◽  
pp. 610-618 ◽  
Author(s):  
Mara Fornaro ◽  
Roberta Dell' Arciprete ◽  
Manuela Stella ◽  
Cecilia Bucci ◽  
Michele Nutini ◽  
...  

1985 ◽  
Vol 28 (4) ◽  
pp. 243-252 ◽  
Author(s):  
Goeh Jung ◽  
David M. Andrews ◽  
Kermit L. Carraway ◽  
Coralie A. Carothers Carraway

Extremophiles ◽  
1997 ◽  
Vol 1 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Hiromichi Wakai ◽  
Satoshi Nakamura ◽  
Hiroshi Kawasaki ◽  
Kei Takada ◽  
Shin Mizutani ◽  
...  

Author(s):  
Frans van Roy ◽  
Volker Nimmrich ◽  
Anton Bespalov ◽  
Achim Möller ◽  
Hiromitsu Hara ◽  
...  

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