Analysis of Assembly and Budding of Lujo Virus
Keyword(s):
The recently identified arenavirus Lujo virus (LUJV) causes fatal hemorrhagic fever in humans. We analyzed its mechanism of viral release driven by matrix protein Z and the cell surface glycoprotein precursor GPC. The L domains in Z are required for efficient virus-like particle release, but Tsg101, ALIX/AIP1, and Vps4A/B are unnecessary for budding. LUJV GPC is cleaved by site 1 protease (S1P) at the RKLM motif, and treatment with the S1P inhibitor PF-429242 reduced LUJV production.
1990 ◽
Vol 32
(2)
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pp. 370-385
Keyword(s):
1993 ◽
Vol 208
(2)
◽
pp. 465-478
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1995 ◽
Vol 62
(5)
◽
pp. 610-618
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Keyword(s):
Keyword(s):
Actin-associated cell-surface glycoprotein from ascites cell microvilli: A disulfide-linked multimer
1985 ◽
Vol 28
(4)
◽
pp. 243-252
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