scholarly journals Molecular Epidemiology and Evolution of Enterovirus 71 Strains Isolated from 1970 to 1998

1999 ◽  
Vol 73 (12) ◽  
pp. 9969-9975 ◽  
Author(s):  
Betty A. Brown ◽  
M. Steven Oberste ◽  
James P. Alexander ◽  
Margery L. Kennett ◽  
Mark A. Pallansch
Keyword(s):  
United States ◽  
Neurological Diseases ◽  
Severe Disease ◽  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
The United States ◽  
Prototype Strain ◽  
Sequence Comparisons ◽  
Rate Of Evolution ◽  
The Republic

ABSTRACT Enterovirus 71 (EV71) (genus Enterovirus, familyPicornaviridae), a common cause of hand, foot, and mouth disease (HFMD), may also cause severe neurological diseases, such as encephalitis and poliomyelitis-like paralysis. To examine the genetic diversity and rate of evolution of EV71, we have determined and analyzed complete VP1 sequences (891 nucleotides) for 113 EV71 strains isolated in the United States and five other countries from 1970 to 1998. Nucleotide sequence comparisons demonstrated three distinct EV71 genotypes, designated A, B, and C. The genetic variation within genotypes (12% or fewer nucleotide differences) was less than the variation between genotypes (16.5 to 19.7%). Strains of all three genotypes were at least 94% identical to one another in deduced amino acid sequence. The EV71 prototype strain, BrCr-CA-70, isolated in California in 1970, is the sole member of genotype A. Strains isolated in the United States and Australia during the period from 1972 to 1988, a 1994 Colombian isolate, and isolates from a large HFMD outbreak in Malaysia in 1997 are all members of genotype B. Although strains of genotype B continue to circulate in other parts of the world, none have been isolated in the United States since 1988. Genotype C contains strains isolated in 1985 or later in the United States, Canada, Australia, and the Republic of China. The annual rate of evolution within both the B and C genotypes was estimated to be approximately 1.35 × 10−2 substitutions per nucleotide and is similar to the rate observed for poliovirus. The results indicate that EV71 is a genetically diverse, rapidly evolving virus. Its worldwide circulation and potential to cause severe disease underscore the need for additional surveillance and improved methods to identify EV71 in human disease.

scholarly journals The status of neurology fellowships in the United States: clinical needs, educational barriers, and future outlooks

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Harini Sarva ◽  
Gustavo A. Patino ◽  
Mehmood Rashid ◽  
James W. M. Owens ◽  
Matthew S. Robbins ◽  
...  
Keyword(s):  
United States ◽  
American Academy ◽  
Neurodegenerative Disorders ◽  
Disease Burden ◽  
Neurological Diseases ◽  
The United States ◽  
Educational Barriers ◽  
The Status

AbstractThe need for subspecialty-trained neurologists is growing in parallel with increasing disease burden. However, despite the immense burden of neurological diseases, like headache and neurodegenerative disorders, recruitment into these subspecialties remains insufficient in the United States. In this manuscript, a group of educators from the American Academy of Neurology’s A.B. Baker Section on Neurological Education sought to review and discuss the current landscape of neurology fellowships in the United States, the factors driving fellowship recruitment and the educational barriers. Moreover, suggestions to potentially improve recruitment for under-selected fellowships, which can contribute towards an alignment between neurological education and neurological needs, and future educational scenarios are discussed.

Negotiating the Cold War: The United States and the Two Koreas

2000 ◽  
Vol 9 (1-2) ◽  
pp. 85-105
Author(s):  
Steven Hugh Lee
Keyword(s):  
United States ◽  
North Korea ◽  
The United States ◽  
Republic Of Korea ◽  
Republic Of China ◽  
South Korean ◽  
Agreed Framework ◽  
Peace Settlement ◽  
The Republic ◽  
The Cold War

AbstractSince December 1997, the Democratic People’s Republic of Korea (DPRK), the People’s Republic of China (PRC), the Republic of Korea (ROK), and the United States have met in a series of talks aimed at promoting peace and stability on the Korean peninsula and in the region. According to a November 1998 U.S. Department of Defense report, the discussions have created a “diplomatic venue for reducing tensions and ultimately replacing the Armistice Agreement with a permanent peace settlement.”1 Amidst the tragic human suffering which has occurred in North Korea, there have been some encouraging developments on the peninsula. The 1994 Agreed Framework between the United States and North Korea placed international controls on North Korea’s atomic energy program and cautiously anticipated the normalization of U.S.-DPRK relations. Since assuming power in early 1998, South Korean President Kim Dae Jung has vigorously pursued a policy of engagement with P’yo¨ngyang, known as the “sunshine policy.” Over the past decade, North Korea has also reoriented its foreign policy. In the early 1990s, the regime’s social and economic crisis led to a rethinking of its autarkic economic system. By early 1994, the state had created new free trade zones and relatively open foreign investment laws.2 By complying with the Agreed Framework, the DPRK has also shown a willingness to work with the international community on sensitive issues affecting its internal sovereignty and ability to project power beyond its borders.

Juárez, Maximilian, and the French Occupation of Mexico

2021 ◽  
Author(s):  
Michael Hogan
Keyword(s):  
United States ◽  
Historical Data ◽  
The United States ◽  
Working Poor ◽  
The Other ◽  
Reform Movement ◽  
Mexican History ◽  
Basic Facts ◽  
The Republic ◽  
Benito Juarez

A tumultuous period in Mexican history began with the Reform Movement of President Benito Juárez, followed by the French invasion and installation of Maximillian as emperor, the defeat of his troops by the liberal army, and the restoration of the Mexican Republic in 1877. Although most of the basic facts of these events are not in dispute, the narrowness of the lens used to examine them is. Some data have been systematically ignored by national historians, and there are also contradictory interpretations of the published historical data. One common reflection on this period is the depiction of Maximilian as liberal whom some argue contributed in a positive way to Mexico. However, some Mexican scholars dispute this. The other widely held belief is that Benito Juárez can be credited with the restoration of the republic and the betterment of the working poor and indigenous. Although criticism of Juárez is uncommon in official circles, where he is idolized, some Mexican scholars are more skeptical of these claims. The missing or generally ignored data concern the contribution of the United States to the defeat of the French and Austrian armies, which is not mentioned in any survey texts and is minimized in most articles. The fuller inclusion of these data coupled with a closer look at the contributions and failures of both the Maximilian and Juárez regimes provides a clearer picture of the epoch and generates new insights.

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