Reciprocal Interactions between Human T-Lymphotropic Virus Type 1 and Prostaglandins: Implications for Viral Transmission
2001 ◽
Vol 75
(1)
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pp. 192-198
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Keyword(s):
ABSTRACT Human T-lymphotropic virus type 1 (HTLV-1), the etiologic agent of adult T-cell leukemia/lymphoma, is transmitted through breast milk and seminal fluid, which are rich in prostaglandins (PGs). We demonstrate that PGE2 upregulates the HTLV-1 long terminal repeat promoter through the protein kinase A pathway, induces replication of HTLV-1 in peripheral blood mononuclear cells (PBMC) derived from asymptomatic carriers, and enhances transmission of HTLV-1 to cord blood mononuclear cells (CBMC). Furthermore, HTLV-1 Tax transactivates a promoter for cyclooxygenase 2, a PG synthetase, and induces PGE2 expression in PBMC or CBMC. Thus, HTLV-1 interacts with and benefits from PGs, constituents of its own vehicle for transmission.
1993 ◽
Vol 48
(2)
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pp. 170-177
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2007 ◽
Vol 121
(10)
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pp. 2205-2211
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2000 ◽
Vol 62
(2)
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pp. 286-292
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1999 ◽
Vol 80
(4)
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pp. 857-861
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2002 ◽
Vol 46
(9)
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pp. 3080-3083
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1990 ◽
Vol 28
(4)
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pp. 734-737
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1996 ◽
Vol 40
(1)
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pp. 234-236
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2012 ◽
Vol 28
(8)
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pp. 806-808
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