Vaccinia Virus Recombinant Expressing an 87-Kilodalton Polyprotein That Is Sufficient To Form Astrovirus-Like Particles

ABSTRACT Human astrovirus is an important cause of acute gastroenteritis. We have generated, for the first time, a vaccinia virus recombinant expressing the astrovirus 87-kDa structural polyprotein. The results demonstrate that this expression results in the formation of virus-like particles in the absence of other astrovirus proteins and genomic RNA. The purified trypsin-activated virus-like particles strongly resemble the complete astrovirus particles.

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Immunization with influenza A NP-expressing vaccinia virus recombinant protects mice against experimental infection with human and avian influenza viruses

Archives of Virology ◽

10.1007/s00705-005-0676-9 ◽

2005 ◽

Vol 151 (5) ◽

pp. 921-931 ◽

Cited By ~ 32

Author(s):

A. D. Altstein ◽

A. K. Gitelman ◽

Y. A. Smirnov ◽

L. M. Piskareva ◽

L. G. Zakharova ◽

...

Keyword(s):

Avian Influenza ◽

Vaccinia Virus ◽

Experimental Infection ◽

Influenza A ◽

Influenza Viruses ◽

Avian Influenza Viruses ◽

Virus Recombinant ◽

Vaccinia Virus Recombinant

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Herpes Simplex Virus Type 1-Vaccinia Virus Recombinant Expressing Glycoprotein B: Protection from Acute and Latent Infection

The Journal of Infectious Diseases ◽

10.1093/infdis/158.6.1382 ◽

1988 ◽

Vol 158 (6) ◽

pp. 1382-1386 ◽

Cited By ~ 18

Author(s):

D. E. Willey ◽

E. M. Cantin ◽

L. R. Hill ◽

B. Moss ◽

A. L. Notkins ◽

...

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Vaccinia Virus ◽

Virus Type ◽

Herpes Simplex Virus Type ◽

Latent Infection ◽

Virus Recombinant ◽

Simplex Virus ◽

Vaccinia Virus Recombinant

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Vaccinia virus recombinant expressing herpes simplex virus type 1 glycoprotein D prevents latent herpes in mice

Science ◽

10.1126/science.2986288 ◽

1985 ◽

Vol 228 (4700) ◽

pp. 737-740 ◽

Cited By ~ 119

Author(s):

K. Cremer ◽

M Mackett ◽

C Wohlenberg ◽

A. Notkins ◽

B Moss

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Vaccinia Virus ◽

Virus Type ◽

Herpes Simplex Virus Type ◽

Glycoprotein D ◽

Virus Recombinant ◽

Simplex Virus ◽

Vaccinia Virus Recombinant

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Protection from rabies by a vaccinia virus recombinant containing the rabies virus glycoprotein gene.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.81.22.7194 ◽

1984 ◽

Vol 81 (22) ◽

pp. 7194-7198 ◽

Cited By ~ 194

Author(s):

T. J. Wiktor ◽

R. I. Macfarlan ◽

K. J. Reagan ◽

B. Dietzschold ◽

P. J. Curtis ◽

...

Keyword(s):

Vaccinia Virus ◽

Rabies Virus ◽

Rabies Virus Glycoprotein ◽

Virus Glycoprotein ◽

Glycoprotein Gene ◽

Virus Recombinant ◽

Vaccinia Virus Recombinant

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Visna/maedi virus Env protein expressed by a vaccinia virus recombinant induces cell-to-cell fusion in cells of different origins in the apparent absence of Env cleavage: role of glycosylation and of proteoglycans

Archives of Virology ◽

10.1007/s00705-002-0874-7 ◽

2002 ◽

Vol 147 (12) ◽

pp. 2377-2392 ◽

Cited By ~ 6

Author(s):

A. B. Sánchez ◽

D. Rodríguez ◽

A. Garzón ◽

B. Amorena ◽

M. Esteban ◽

...

Keyword(s):

Vaccinia Virus ◽

Cell Fusion ◽

Apparent Absence ◽

Virus Recombinant ◽

Env Protein ◽

Different Origins ◽

Vaccinia Virus Recombinant ◽

In Cells

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Rescue of Sindbis virus-specific RNA replication and transcription by using a vaccinia virus recombinant.

Journal of Virology ◽

10.1128/jvi.65.12.6714-6723.1991 ◽

1991 ◽

Vol 65 (12) ◽

pp. 6714-6723 ◽

Cited By ~ 4

Author(s):

G P Li ◽

B M Prágai ◽

C M Rice

Keyword(s):

Vaccinia Virus ◽

Sindbis Virus ◽

Rna Replication ◽

Virus Recombinant ◽

Vaccinia Virus Recombinant

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Expression of the Hantaan virus M genome segment by using a vaccinia virus recombinant.

Journal of Virology ◽

10.1128/jvi.62.3.696-702.1988 ◽

1988 ◽

Vol 62 (3) ◽

pp. 696-702 ◽

Cited By ~ 37

Author(s):

M N Pensiero ◽

G B Jennings ◽

C S Schmaljohn ◽

J Hay

Keyword(s):

Vaccinia Virus ◽

Genome Segment ◽

Hantaan Virus ◽

Virus Recombinant ◽

M Genome ◽

Vaccinia Virus Recombinant

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Resistance to respiratory syncytial virus (RSV) challenge induced by infection with a vaccinia virus recombinant expressing the RSV M2 protein (Vac-M2) is mediated by CD8+ T cells, while that induced by Vac-F or Vac-G recombinants is mediated by antibodies.

Journal of Virology ◽

10.1128/jvi.66.2.1277-1281.1992 ◽

1992 ◽

Vol 66 (2) ◽

pp. 1277-1281 ◽

Cited By ~ 58

Author(s):

M Connors ◽

A B Kulkarni ◽

P L Collins ◽

C Y Firestone ◽

K L Holmes ◽

...

Keyword(s):

T Cells ◽

Respiratory Syncytial Virus ◽

Vaccinia Virus ◽

Cd8 T Cells ◽

M2 Protein ◽

Virus Recombinant ◽

Syncytial Virus ◽

Vaccinia Virus Recombinant

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NOVEL VACCINIA VIRUS RECOMBINANT FOR HUMAN SOLID TUMORS THERAPY – PRECLINICAL TRIALS RESULTS

BIOTECHNOLOGY: STATE OF THE ART AND PERSPECTIVES ◽

10.37747/2312-640x-2020-18-109-110 ◽

2020 ◽

pp. 109-110

Author(s):

O. Koval ◽

G. Kochneva ◽

V. Richter

Keyword(s):

Vaccinia Virus ◽

Solid Tumors ◽

Recombinant Vaccinia Virus ◽

Preclinical Studies ◽

Gm Csf ◽

Preclinical Trials ◽

Human Solid Tumors ◽

Virus Recombinant ◽

Vaccinia Virus Recombinant ◽

Double Recombinant

A double recombinant vaccinia virus VV-GMCSF-Lact, producing human GM-CSF and oncotoxic protein lactaptin, was constructed. Preclinical studies of VV-GMCSF-Lact as an antitumor drug for human solid tumors therapy were successfully completed. The drug is recommended for clinical trials.

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