The cap of both miniexon-derived RNA and mRNA of trypanosomes is 7-methylguanosine
Most, if not all, trypanosome mRNAs have the same 35-base sequence at their 5' terminus which is derived from a short RNA (medRNA) probably by the process of trans-splicing. It is of interest, evolutionarily and mechanistically, to determine the chemical structure of the 5' terminus of the precursor (medRNA) and product (mRNA). We demonstrate here that the cap structure of both is most probably 7-methylguanosine in a 5',5' triphosphate linkage, consistent with a precursor/product relationship.
1988 ◽
Vol 8
(1)
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pp. 494-496
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1978 ◽
Vol 36
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pp. 259-267
1990 ◽
Vol 48
(4)
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pp. 710-711
2016 ◽
Vol 86
(3-4)
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pp. 127-151
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1877 ◽
Vol 4
(98supp)
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pp. 1560-1560
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