scholarly journals Anaplerotic Role of Glucose in the Oxidation of Endogenous Fatty Acids during Dengue Virus Infection

mSphere ◽  
2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Lorena O. Fernandes-Siqueira ◽  
Julianna D. Zeidler ◽  
Bruna G. Sousa ◽  
Thiago Ferreira ◽  
Andrea T. Da Poian
Keyword(s):  
Fatty Acids ◽  
Lipid Metabolism ◽  
Virus Infection ◽  
Dengue Virus ◽  
Severe Disease ◽  
Severe Dengue ◽  
Dengue Virus Infection ◽  
Hepatic Cells ◽  
Lipid Metabolism Disorders

Dengue virus infection is a major cause of human arbovirosis, for which clinical and experimental evidence supports the idea that liver dysfunction and lipid metabolism disorders are characteristics of severe disease. Analyzing mitochondrial bioenergetics, here we show that infection of hepatic cells with dengue virus favors the cellular capacity of metabolizing glucose, impairing the normal metabolic flexibility that allows the oxidative machinery to switch among the main energetic substrates. However, instead of being used as an energy source, glucose performs an anaplerotic role in the oxidation of endogenous fatty acids, which become the main energetic substrate during infection. Taken together, the results shed light on metabolic mechanisms that may explain the profound alterations in lipid metabolism for severe dengue patients, contributing to the understanding of dengue physiopathology.

scholarly journals Serotype and Clinical Performance of Dengue Virus Infection on the Year 2009

2010 ◽  
Vol 1 (2) ◽  
pp. 55 ◽  
Author(s):  
Soegeng Soegijanto ◽  
Widodo Darmowandowo ◽  
Amor Peraten Ginting ◽  
Atsushi Yamanaka
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Clinical Manifestation ◽  
Clinical Performance ◽  
Secondary Infection ◽  
Severe Disease ◽  
Dengue Shock Syndrome ◽  
Severe Dengue ◽  
Rt Pcr ◽  
Dengue Virus Infection

Dengue hemorrhagic fever is one of the important health problem in Indonesia, mortality rate is becoming decrease but many dengue shock syndrome cases is very difficult to be help. Previous study showed that some of DEN 2 and DEN 3 virus cases could show a clinical performance of severe dengue virus infection such as dengue shock syndrome. There are four serotype of dengue virus infection can cause primary and secondary infection. The aim of this research is to know the relationship between clinical performance of dengue virus infection and serotype dengue virus and also to know the role of primary and secondary infection and age of dengue virus cases. A prospective analytic observational study, which was conducted in Dr. Soetomo hospital since January 2009. RT-PCR was used to attempt to identify the infecting serotype from dengue virus isolated using vero cell. Antibody responses were measured by ELISA and clinical manifestation were measured with the WHO criteria 1997. Dengue serotype identification by RT-PCR was 70 patients. Virus types were DEN-2 65(92.8%), DEN-1 3(4.2%), and DEN-3 2(2.8%). Patients with DEN-1 genotype IV were more trend severe disease DSS and unusual infection. Commanly usually secondary exposure cause more severe clinical manifestation than primary exposure (p = 0.035) but in this study found that all of DEN-1 genotype IV, primary or secondary infection to show severe clinical manifestation of dengue virus infection. We can conclude that DEN-2 was the most dominant serotype in Dr. Soetomo Hospital. On Primary and secondary infection, DEN-1 genotype IV showing more severe than DEN-2 and DEN-3.

Case Report: Transmission of Dengue Virus from a Deceased Donor to a Kidney Transplant Recipient Previously Infected by Dengue Virus

2021 ◽  
Author(s):  
Arnaud Lecadieu ◽  
Laura Teysseyre ◽  
Kevin Larsen ◽  
Charles Vidal ◽  
Margot Caron ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
Deceased Donor ◽  
Severe Dengue ◽  
Reunion Island ◽  
Dengue Virus Infection ◽  
First Case ◽  
Réunion Island

Since 2018, a dengue epidemic has been ongoing in the French overseas department of Reunion Island, in the Indian Ocean, with more than 25,000 serologically confirmed cases. Currently, three dengue serotypes have been identified in Réunion Island (DENV-1, DENV-2, and DENV-3) progressing in the form of epidemic outbreaks. This arbovirus is mainly transmitted by mosquitoes of the genus Aedes and may be responsible for serious clinical forms. To date, very few cases of kidney transplant–related dengue virus infection have been described. Here we report the first case of severe dengue virus infection related to kidney transplantation from a patient previously infected with dengue. Testing for dengue fever with PCR search in donor’s urine may help complete the pretransplant assessment in areas where this disease occurs.

Lost in post-translational modification—Dengue virus writes its own sequel

2021 ◽  
Vol 6 (61) ◽  
pp. eabk1555
Author(s):  
Soumya S. Yandamuri ◽  
Kevin C. O’Connor
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Severe Disease ◽  
Post Translational Modification ◽  
Dengue Virus Infection ◽  
Elevated Frequency ◽  
Prior Infection

Elevated frequency of afucosylated IgG1 antibodies during dengue virus infection is associated with prior infection and predicts severe disease.

scholarly journals Seroepidemiology of dengue virus infection among adults during the ending phase of a severe dengue epidemic in southern Taiwan, 2015

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yu-Wen Chien ◽  
Hsiang-Min Huang ◽  
Tzu-Chuan Ho ◽  
Fan-Chen Tseng ◽  
Nai-Ying Ko ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Severe Dengue ◽  
Dengue Virus Infection ◽  
Southern Taiwan ◽  
Dengue Epidemic

scholarly journals 1254 The Role of Psidii Guava Leaf Extract to Increase Platelet Level in Dengue Virus Infection

2010 ◽  
Vol 68 ◽  
pp. 621-621
Author(s):  
S Soegijanto ◽  
D Azhali ◽  
A R Tumbelaka ◽  
R Rufiati ◽  
D Anggraini ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Leaf Extract ◽  
Dengue Virus Infection ◽  
Platelet Level ◽  
Guava Leaf

scholarly journals Current Understanding of the Pathogenesis of Dengue Virus Infection

2020 ◽  
Author(s):  
Puneet Bhatt ◽  
Sasidharan Pillai Sabeena ◽  
Muralidhar Varma ◽  
Govindakarnavar Arunkumar
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Virus Infection ◽  
Dengue Virus ◽  
Genetic Factors ◽  
Host Immune Response ◽  
Severe Dengue ◽  
Ns1 Protein ◽  
Dengue Virus Infection ◽  
Antibody Dependent Enhancement

AbstractThe pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility. NS1 protein and anti-DENV NS1 antibodies were believed to be responsible for pathogenesis of severe dengue. The cytokine response of cross-reactive CD4+ T cells might be altered by the sequential infection with different DENV serotypes, leading to further elevation of pro-inflammatory cytokines contributing a detrimental immune response. Fcγ receptor-mediated antibody-dependent enhancement (ADE) results in release of cytokines from immune cells leading to vascular endothelial cell dysfunction and increased vascular permeability. Genomic variation of dengue virus and subgenomic flavivirus RNA (sfRNA) suppressing host immune response are viral determinants of disease severity. Dengue infection can lead to the generation of autoantibodies against DENV NS1antigen, DENV prM, and E proteins, which can cross-react with several self-antigens such as plasminogen, integrin, and platelet cells. Apart from viral factors, several host genetic factors and gene polymorphisms also have a role to play in pathogenesis of DENV infection. This review article highlights the various factors responsible for the pathogenesis of dengue and also highlights the recent advances in the field related to biomarkers which can be used in future for predicting severe disease outcome.

scholarly journals The role of lipids in the inception, maintenance and complications of dengue virus infection

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Carlos Fernando Odir Rodrigues Melo ◽  
Jeany Delafiori ◽  
Mohamad Ziad Dabaja ◽  
Diogo Noin de Oliveira ◽  
Tatiane Melina Guerreiro ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Dengue Virus Infection

scholarly journals The Role of Heterotypic DENV-specific CD8 + T Lymphocytes in an Immunocompetent Mouse Model of Secondary Dengue Virus Infection

EBioMedicine ◽  
2017 ◽  
Vol 20 ◽  
pp. 202-216 ◽  
Author(s):  
Laura B. Talarico ◽  
Juan P. Batalle ◽  
Alana B. Byrne ◽  
Jorge M. Brahamian ◽  
Adrián Ferretti ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Virus Infection ◽  
Mouse Model ◽  
Dengue Virus ◽  
Immunocompetent Mouse ◽  
Dengue Virus Infection ◽  
Cd8 T Lymphocytes

scholarly journals OL-031 The role of Interleukin-12p70 in dengue virus infection

2010 ◽  
Vol 14 ◽  
pp. S14
Author(s):  
J. You ◽  
Q.-Q. Wang ◽  
L. Zhuang ◽  
X. Feng ◽  
R.-D. Yang ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Dengue Virus Infection
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