Background:
Bacterial infections are considered as one of the major global health
threats, so it is very essential to design and develop new antibacterial agents to overcome the
drawbacks of existing antibacterial agents.
Method:
The aim of this work is to synthesize a series of new fluoroquinolone-3-carboxamide
amino acid conjugates by molecular hybridization. We utilized benzotriazole chemistry to synthesize
the desired hybrid conjugates.
Result:
All the conjugates were synthesized in good yields, characterized, evaluated for their antibacterial
activity. The compounds were screened for their antibacterial activity using methods
adapted from the Clinical and Laboratory Standards Institute. Synthesized conjugates were tested
for activity against medically relevant pathogens; Escherichia coli (ATCC 25922), Pseudomonas
aeruginosa (ATCC 27856) Staphylococcus aureus (ATCC 25923) and Enterococcus faecalis
(ATCC 19433).
Conclusion:
The observed antibacterial experimental data indicates the selectivity of our synthesized
conjugates against E.Coli. The protecting group on amino acids decreases the antibacterial
activity. The synthesized conjugates are non-toxic to the normal cell lines. The experimental data
were supported by computational studies.
New method of preparation of carboxy-protected amino acid conjugates of glycyrrhizinic acid
