Design and Synthesis of Novel β-Carboline Linked Amide Derivatives as Anticancer Agents

We live in a world with complex diseases such as cancer which cannot be cured with one-compound one-target based therapeutic paradigm. This could be due to the involvement of multiple pathogenic mechanisms. One-compound-various-targets stratagem has become a prevailing research topic in anti-cancer drug discovery. The simultaneous interruption of two or more targets has improved the therapeutic efficacy as compared to the specific targeted based therapy. In this review, six types of dual targeting agents along with some interesting strategies used for their design and synthesis are discussed. Their pharmacology with various types of the molecular interactions within their specific targets has also been described. This assemblage will reveal the recent trends and insights in front of the scientific community working in dual inhibitors and help them in designing the next generation of multi-targeted anti-cancer agents.

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Design and Synthesis of Sulfonamide‐Attached 2‐(Isoxazol‐3‐yl)‐1 H ‐imidazoles as Anticancer Agents

ChemistrySelect ◽

10.1002/slct.202001449 ◽

2020 ◽

Vol 5 (26) ◽

pp. 7919-7922

Author(s):

Satheesh Kumar Dende ◽

Raghu Babu Korupolu ◽

Krishnakanth Reddy Leleti

Keyword(s):

Anticancer Agents ◽

Design And Synthesis

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Design and Synthesis of 3‘- and 5‘-O-(3-Benzenesulfonylfuroxan-4-yl)-2‘-deoxyuridines: Biological Evaluation as Hybrid Nitric Oxide Donor−Nucleoside Anticancer Agents

Journal of Medicinal Chemistry ◽

10.1021/jm030544m ◽

2004 ◽

Vol 47 (7) ◽

pp. 1840-1846 ◽

Cited By ~ 33

Author(s):

Sameh Moharram ◽

Aihua Zhou ◽

Leonard I. Wiebe ◽

Edward E. Knaus

Keyword(s):

Nitric Oxide ◽

Anticancer Agents ◽

Biological Evaluation ◽

Nitric Oxide Donor ◽

Design And Synthesis

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Synthesis and Experimental Validation of New Designed Heterocyclic Compounds with Antiproliferative Activity versus Breast Cancer Cell Lines MCF-7 and MDA-MB-231

Journal of Chemistry ◽

10.1155/2017/9729284 ◽

2017 ◽

Vol 2017 ◽

pp. 1-10 ◽

Cited By ~ 2

Author(s):

Vincenza Barresi ◽

Carmela Bonaccorso ◽

Domenico A. Cristaldi ◽

Maria N. Modica ◽

Nicolò Musso ◽

...

Keyword(s):

Cell Line ◽

Cell Lines ◽

Cancer Cell ◽

Anticancer Agents ◽

Cancer Cell Line ◽

Breast Cancer Cell Lines ◽

Design And Synthesis ◽

Human Breast Cell ◽

Mcf 7

Recent drug discovery efforts are highly focused towards identification, design, and synthesis of small molecules as anticancer agents. With this aim, we recently designed and synthesized novel compounds with high efficacy and specificity for the treatment of breast tumors. Based on the obtained results, we constructed a Volsurf+ (VS+) model using a dataset of 59 compounds able to predict the in vitro antitumor activity against MCF-7 cancer cell line for new derivatives. In the present paper, in order to further verify the robustness of this model, we report the results of the projection of more than 150 known molecules and 9 newly synthesized compounds. We predict their activity versus MCF-7 cell line and experimentally verify the in silico results for some promising chosen molecules in two human breast cell lines, MCF-7 and MDA-MB-231.

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