Synthesis of New Fused Thieno[3,2-d]pyrimidines Based on Thieno[3,2-d][1,3]oxazine Derivative

2019 ◽  
Vol 89 (4) ◽  
pp. 847-851 ◽  
Author(s):  
V. V. Dabaeva ◽  
M. R. Bagdasaryan ◽  
E. G. Paronikyan ◽  
Sh. Sh. Dashyan
Keyword(s):  
RSC Advances ◽  
2015 ◽  
Vol 5 (42) ◽  
pp. 33623-33631 ◽  
Author(s):  
Tong Zhang ◽  
Jun Wang ◽  
Tiantian Feng ◽  
Hui Wang ◽  
Noureddine Ramdani ◽  
...  

A novel tetrafunctional oxazine monomer containing benzoxazine and fluorene-oxazine was prepared for the first time using a Mannich condensation reaction of 2,7-dihydroxy-9,9-bis-(4-hydroxyphenyl)fluorene with paraformaldehyde and n-butylamine.


2005 ◽  
Vol 23 (5) ◽  
pp. 577-583 ◽  
Author(s):  
Martin Hintersteiner ◽  
Albert Enz ◽  
Peter Frey ◽  
Anne-Lise Jaton ◽  
Willy Kinzy ◽  
...  

2014 ◽  
Vol 10 ◽  
pp. 1749-1758 ◽  
Author(s):  
Maja Kandziora ◽  
Hans-Ulrich Reissig

An approach to β-D-2-aminotalose- and β-D-2-aminoidose-configured carbohydrate mimetics bearing a phenyl substituent is described. Unnatural divalent rigid p-terphenyl-linked C-aryl glycosides with 2.0 nm dimension are available using Suzuki cross-couplings. The key compound, a p-bromophenyl-substituted 1,2-oxazine, was prepared by a stereoselective [3 + 3]-cyclization of a D-isoascorbic acid-derived (Z)-nitrone and lithiated TMSE-allene. The Lewis acid-induced rearrangement of this heterocycle provided the corresponding bicyclic 1,2-oxazine derivative that may be regarded as internally protected amino sugar analogue. After subsequent reduction of the carbonyl group, the resulting bicyclic compound was used for Suzuki cross-couplings to form biphenyl aminopyran or p-terphenyl-linked dimers. Hydrogenolysis afforded new unnatural aminosugar mimetics. Zinc in the presence of acid or samarium diiodide were examined for the N–O bond cleavage in order to obtain the rigid p-terphenyl-linked C-glycosyl dimers.


1995 ◽  
Vol 33 (7) ◽  
pp. 600-602 ◽  
Author(s):  
Frank G. Riddell ◽  
Martin Rogerson ◽  
Ferenc Fülöp ◽  
Gábor Bernáth

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