Papain-catalyzed synthesis of phenylhydrazides of N-acylamino acids

1984 ◽  
Vol 49 (11) ◽  
pp. 2557-2561 ◽  
Author(s):  
Václav Čeřovský ◽  
Karel Jošt
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Derivatives Of ◽  
Acyl Derivatives

Phenylhydrazides of Nα-acyl derivatives of all coded amino acids, except proline, were prepared by papain (E.C. 3.4.22.2)-catalyzed synthesis. Comparison of yields affords information about the suitability of the amino acid in position P1 in papain-catalyzed syntheses of peptides.

Some N-acyl-D-amino acid derivatives having antibotulinal properties

1987 ◽  
Vol 33 (7) ◽  
pp. 577-582 ◽  
Author(s):  
A. Paquet ◽  
K. Rayman
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Aspartic Acid ◽  
Sodium Nitrite ◽  
Amino Acid Derivatives ◽  
Ester Method ◽  
Succinimidyl Ester ◽  
High Yields ◽  
Derivatives Of ◽  
Acyl Derivatives

Several N-acyl derivatives of D-tryptophan, D-alanine, D-methionine, D-valine, and D-aspartic acid were synthesized in high yields using the succinimidyl ester method and examined for their antibotulinal properties. In conjunction with 60 ppm of sodium nitrite, sorbyl-D-tryptophan, sorbyl-D-alanine, myristoyl-D-aspartic acid, and glycyl-D-alanine were highly inhibitory. In the absence of sodium nitrite, the N-acyl derivatives of the D-amino acids were not inhibitory. On its own, 60 ppm of sodium nitrite was only slightly inhibitory. Sorbyl-L-tryptophan and sorbyl-L-alanine had no effect in the presence or absence of 60 ppm of sodium nitrite.

Synthesis and Fungicidal Activity of Lipophylic N- and O-Acyl Derivatives of β-Hydroxy ᴅʟ-α-Amino Acids

2003 ◽  
Vol 58 (5-6) ◽  
pp. 366-370 ◽  
Author(s):  
Nijole Dirvianskytė ◽  
Juozapas Straukas ◽  
Valdemaras Razumas ◽  
Eugenius Butkus
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Verticillium Dahliae ◽  
Fungicidal Activity ◽  
Growth Of Fungi ◽  
Derivatives Of ◽  
Acyl Derivatives ◽  
Acid Structure ◽  
Long Chain ◽  
Amino Acid Structure

Abstract Synthesis of N- and O-acyl derivatives of ᴅʟ-serine and threo-ᴅʟ-phenylserine was accomplished by a regioselective acylation of the corresponding amino acid. The residues introduced into amino acid structure contain hydrophobic long chain or aromatic, namely lauroyl, myristoyl and phenylacetyl moieties. The fungicidal activity against six strains of fungi was studied. Several compounds were found to be effective against growth of fungi, and Omyristoyl- ᴅʟ-serine 2 and N-phenylacetyl-threo-ᴅʟ-phenylserine 8 completely inhibited the growth of the mycelium of the fungus Verticillium dahliae.

ChemInform Abstract: N-ACYL DERIVATIVES OF ORGANOPHOSPHORUS ANALOGS OF AMINO ACIDS, THEIR ESTERS AND AMIDES

1980 ◽  
Vol 11 (15) ◽  
Author(s):  
N. B. TARUSOVA ◽  
I. A. GANDURINA ◽  
YU. N. ZHUKOV ◽  
G. M. YAKOVLEVA ◽  
R. M. KHOMUTOV
Keyword(s):  
Amino Acids ◽  
Derivatives Of ◽  
Acyl Derivatives

N-DICHLOROACETYL DERIVATIVES OF SERINE AND THREONINE AND OF THEIR ESTERS AND SODIUM SALTS

1960 ◽  
Vol 38 (7) ◽  
pp. 1135-1140 ◽  
Author(s):  
I. Levi ◽  
A. E. Koller ◽  
G. Laflamme ◽  
J. W. R. Weed
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Antitumor Activity ◽  
Amino Acid Ester ◽  
Amino Group ◽  
Sodium Salts ◽  
Sarcoma 37 ◽  
Walker Carcinoma ◽  
Derivatives Of ◽  
Dichloroacetyl Chloride

The N-dichloroacetyl derivatives of DL-serine and DL-threonine were prepared by the Schotten–Baumann reaction from the amino acids and dichloroacetyl chloride. Negative ninhydrin tests coupled with elementary analyses indicated that only the amino group was acylated. The ester derivatives of these compounds were prepared either by esterification of the N-dichloroacetyl-DL-amino acid with diazomethane or by the reaction of the amino acid ester with dichloroacetyl chloride in the presence of triethylamine. The sodium salts and the esters were tested for antitumor activity against sarcoma 37 in mice and Walker carcinoma 256 in rats. In both cases regression of the tumors was obtained.

scholarly journals The sequence of amino acids in insulin isolated from islet tissue of the cod (Gadus callarias)

1968 ◽  
Vol 110 (2) ◽  
pp. 289-296 ◽  
Author(s):  
K. B. M. Reid ◽  
P T Grant ◽  
A. Youngson
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Amino Acid Sequences ◽  
Small Peptides ◽  
Islet Tissue ◽  
Complete Digestion ◽  
The Individual ◽  
Derivatives Of

1. S-Aminoethylcysteinyl derivatives of the A and B chains of cod insulin were prepared from the individual S-sulpho chains. 2. Studies on small peptides derived from the S-aminoethylated peptide chains by treatment with trypsin allowed the amino acid sequences in the region of the cysteinyl residues of the A and B peptide chains to be defined. 3. The six amide groups in cod insulin were located by complete digestion of small peptides from the A and B chains with aminopeptidase followed by amino acid analyses. 4. The results, together with previous studies on the oxidized A and B chains, define the sequences of the 51 amino acids that constitute cod insulin.

N-acyl derivatives of organophosphorus analogs of amino acids, their esters, and amides

1979 ◽  
Vol 28 (7) ◽  
pp. 1475-1478
Author(s):  
N. B. Tarusova ◽  
I. A. Gandurina ◽  
Yu. N. Zhukov ◽  
G. M. Yakovleva ◽  
R. M. Khomutov
Keyword(s):  
Amino Acids ◽  
Derivatives Of ◽  
Acyl Derivatives

Nuclear Magnetic Resonance Studies of Phenylthiohydantoin Amino Acids

1975 ◽  
Vol 53 (9) ◽  
pp. 1005-1009 ◽  
Author(s):  
C. S. Tsai ◽  
N. L. Fraser ◽  
H. Avdovich ◽  
J. P. Farant
Keyword(s):  
Amino Acids ◽  
Nuclear Magnetic Resonance ◽  
Amino Acid ◽  
Magnetic Resonance ◽  
Diagnostic Purpose ◽  
Edman Degradation ◽  
Terminal Amino Acid ◽  
Magnetic Resonance Studies ◽  
Terminal Amino ◽  
Derivatives Of

Proton magnetic spectra of 3-phenyl-2-thiohydantoin derivatives of common amino acids in deuterated dimethyl sulfoxide were recorded. Spectral data pertaining to characteristic protons for diagnostic purpose were compiled. Their application to the N-terminal amino acid analysis of peptide by Edman degradation was examined.

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