Synthesis of Pyrazole Analogs from Argentatin B

1995 ◽  
Vol 60 (4) ◽  
pp. 612-618 ◽  
Author(s):  
Roberto Martínez ◽  
Elda Limón ◽  
María del R. Arellano ◽  
Mariano Martínez ◽  
Marco Brito
Keyword(s):  
Mass Spectroscopy ◽  
Pyrazole Derivatives ◽  
C Nmr

The pyrazole derivatives 3'-(2-R-phenyl)[3,2-c]pyrazole-16,24-epoxy-25-hydroxy-9 ,19-cyclostane Va - Vf have been prepared in a three step reaction from argentatin B. The structure of all the compounds synthesized was corroborated by 1H and 13C NMR, IR and mass spectroscopy.

scholarly journals Acid-Promoted Synthesis of Imidazolyl-Pyrazole Derivatives via a Multicomponent Reaction Using Ultra Sound Irradiation

2014 ◽  
Vol 30 ◽  
pp. 277-283
Author(s):  
Denish J. Viradiya ◽  
Vipul C. Kotadiya ◽  
Rajesh Kakadiya ◽  
Anamik Shah
Keyword(s):  
Acetic Acid ◽  
Mass Spectroscopy ◽  
Multicomponent Reaction ◽  
High Purity ◽  
Ammonium Acetate ◽  
Analytical Techniques ◽  
Ultra Sound ◽  
Pyrazole Derivatives ◽  
Heterocyclic Aldehyde ◽  
C Nmr

Some new imidazolyl pyrazole derivatives have been synthesized using benzil, ammonium acetate, and heterocyclic aldehyde in ethanol and acetic acid under ultra sound irradiation. The obtained products using this approach are having high purity and good in yield. By conducting the reactions in ethanol, the solid products were precipitated out and could be isolated simply by filtration. The synthesized compounds were characterized by various analytical techniques such as 1H and 13C NMR and further supported by mass spectroscopy.

Synthesis, Characterization and Complexation Studies with K + and Ca2+ Cations of trans-1.2-Cyclohexanedioxydiacetamides

1988 ◽  
Vol 43 (2) ◽  
pp. 165-170 ◽  
Author(s):  
Whei Oh Lin ◽  
Maria C. B. V. de Souza ◽  
Helmut G. Alt
Keyword(s):  
Nmr Spectroscopy ◽  
Mass Spectroscopy ◽  
H Nmr ◽  
Coordination Sites ◽  
Complexation Studies ◽  
Ir And Nmr Spectroscopy ◽  
Elemental Analyses ◽  
C Nmr

The synthesis of trans-1.2-cyclohexanedioxydiacetamides starting with trans-1.2-cyclohexane-diol is described. Eleven of these compounds are characterized by IR, 1H NMR, 13C NMR and mass spectroscopy as well as elemental analyses. Most of these compounds are suitable ionophors for the cations K+ and Ca2+. The coordination sites of these ligands in the 1:2 complexes were determined by IR and NMR spectroscopy

Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation

2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Zafer Sahin ◽  
Yağmur Özhan ◽  
Hande Sipahi ◽  
Sevde Nur Biltekin ◽  
Leyla Yurttaş ◽  
...  
Keyword(s):  
Hydroxy Ketone ◽  
No Production ◽  
Raw 264.7 ◽  
Pyrazole Derivatives ◽  
H Nmr ◽  
Pyrazolone Derivatives ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Cox 1 ◽  
C Nmr

Abstract Novel benzofurane-pyrazolone hybrids have been synthesized for evaluating their anti-inflammatory and cytotoxic properties. 4-(2-chloroacetyl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one were reacted with α-hydroxy aldehyde or α-hydroxy ketone derivatives to obtain nine novel pyrazolone derivatives. Structures were successfully elucidated by 1H NMR, 13C NMR, IR and HRMS. Enzyme inhibitory activity was measured on cyclooxygenases (COXs) as considered to address anti-inflammatory activity. Compound 2 showed the highest activity on both COX-1 and COX-2 subtypes with 12.0 μM and 8.0 μM IC50, respectively. This activity was found close to indomethacin COX-2 inhibition measured as 7.4 μM IC50. Rest of the compounds (1, 3–9) showed 10.4–28.1 μM IC50 on COX-2 and 17.0–35.6 μM IC50 on COX-1 (Compound 1 has no activity on COX-1). Tested compounds (1–9) showed activity on NO production. Only compound was the 4, which showed a low inhibition on IL-6 levels. Cell viability was up to 60% at 100 μM for all compounds (1–9) on RAW 264.7 and NIH3T3 cell lines, thus compounds were reported to be noncytotoxic.

Structure cristalline et moléculaire d'un composé tricyclique contenant le cycle à dix chaînons dioxo diaza diphosphécine

1992 ◽  
Vol 70 (3) ◽  
pp. 809-816 ◽  
Author(s):  
Brigitte Duthu ◽  
Karim El Abed ◽  
Douraid Houalla ◽  
Robert Wolf ◽  
Joël Jaud
Keyword(s):  
Molecular Structure ◽  
Comparative Analysis ◽  
Double Bond ◽  
Mass Spectroscopy ◽  
Crystal And Molecular Structure ◽  
Accurate Information ◽  
X Ray Diffraction ◽  
X Ray ◽  
Nmr Parameters ◽  
C Nmr

The sulfuration of the tricyclic organophosphorous dimer 2 leads easily to the dithiotricyclic derivative 3, which has been characterized by 31P, 1H, and 13C NMR, elemental analysis, and mass spectroscopy. Its crystal and molecular structure has been established by X-ray diffraction and compared to that of 2, which was previously determined. The comparative analysis of X-ray diffraction and NMR parameters gives accurate information about the molecular structure of both compounds. A numerical value of the anistropy cone of the P=S double bond is proposed. Keywords: phosphecine, NMR, X-ray, tricycle.

Betulin aus archäologischem Schwelteer / Identification of Betulin in Archaeological Tar

1987 ◽  
Vol 42 (11-12) ◽  
pp. 1151-1152 ◽  
Author(s):  
F. Sauter ◽  
E. W. H. Hayek ◽  
W. Moche ◽  
U. Jordis
Keyword(s):  
Iron Age ◽  
Mass Spectroscopy ◽  
Early Iron Age ◽  
Archaeological Wood ◽  
Wood Tar ◽  
C Nmr

A compound obtained from an early Iron-Age wood tar via “Kugelrohr”-distillation or extraction was identified as betulin by TLC. 1H - and 13C - NMR as well as by mass spectroscopy. This result validates the assumption that birch was used for the preparation of the archaeological wood tar found at the excavation in Stillfried a .d . March. Lower Austria.

scholarly journals Synthesis of compounds related to the anti-migraine drug eletriptan hydrobromide

2012 ◽  
Vol 8 ◽  
pp. 1400-1405 ◽  
Author(s):  
Suri Babu Madasu ◽  
Nagaji Ambabhai Vekariya ◽  
M N V D Hari Kiran ◽  
Badarinadh Gupta ◽  
Aminul Islam ◽  
...  
Keyword(s):  
Mass Spectroscopy ◽  
Acute Treatment ◽  
Selective Serotonin ◽  
Spectroscopic Techniques ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
H Nmr ◽  
Related Compounds ◽  
C Nmr ◽  
Anti Migraine Drug

Eletriptan hydrobromide (1) is a selective serotonin (5-HT1) agonist, used for the acute treatment of the headache phase of migraine attacks. During the manufacture of eletriptan hydrobromide the formation of various impurities were observed and identified by LC–MS. To control the formation of these impurities during the preparation of active pharmaceutical ingredients, the structure of the impurities must be known. Major impurities of the eletriptan hydrobromide synthesis were prepared and characterized by using various spectroscopic techniques, i.e., mass spectroscopy, FTIR , 1H NMR, 13C NMR/DEPT, and further confirmed by co-injection in HPLC. The present study will be of great help in the synthesis of highly pure eletriptan hydrobromide related compounds.

scholarly journals Applications D'Intelligence Artificielle Dans La Chimie Organique. XVII. Nouveaux Programmes Du Projet SISTEMAT

1994 ◽  
Vol 12 (2) ◽  
pp. 91-98 ◽  
Author(s):  
Vincente de Paulo Emerenciano ◽  
Gilberto do V. Rodrigues ◽  
Patricia A. T. Macari ◽  
Sandra A. Vesti ◽  
Joao H. G. Borges ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Natural Products ◽  
Magnetic Resonance ◽  
Data Base ◽  
Mass Spectroscopy ◽  
Nmr Spectra ◽  
Heuristic Rules ◽  
Structure Generation ◽  
Natural Products Chemistry ◽  
C Nmr

This work describes the new improvements of the SISlEMAT project, one system for structural elucidation mainly in the field of Natural Products Chemistry. Some examples of the resolution of problems using13C Nuclear Magnetic Resonance and Mass Spectroscopy are given. Programs to discover new heuristic rules for structure generation are discussed. The data base contains about 100013C NMR spectra.

Structure de l'opigénine: triterpène pentacyclique isolé d'Opilia celtidifolia

1986 ◽  
Vol 64 (2) ◽  
pp. 295-299 ◽  
Author(s):  
Danièle Druet ◽  
Louis Comeau ◽  
Jean-Pierre Zahra
Keyword(s):  
Nmr Spectroscopy ◽  
Mass Spectroscopy ◽  
Isopropyl Group ◽  
Glycosidic Fraction ◽  
C Nmr

The structure of opigenin, an aglycone from the glycosidic fraction of Opiliaceltidifolia, has been established by study of the genin and its derivatives by means of ir, mass spectroscopy, and 1H and 13C nmr spectroscopy. This is a new triterpene whose skeleton resembles that of 3β-hydroxy lupane but with an isopropyl group in position 20 and an oxymethylene bridge in position 20–28.

Darstellung und Struktur von Dimesitylzinnoxid / Synthesis and Structure of Dimesityltinoxide

1982 ◽  
Vol 37 (10) ◽  
pp. 1316-1321 ◽  
Author(s):  
U. Weber ◽  
N. Pauls ◽  
W. Winter ◽  
H. B. Stegmann
Keyword(s):  
Mass Spectroscopy ◽  
Aqueous Ammonia ◽  
Asymmetric Unit ◽  
Space Group ◽  
X Ray ◽  
R Factor ◽  
Twist Conformation ◽  
Oxygen Heterocycles ◽  
C Nmr

Abstract Trimesityltin bromide reacts with concentrated aqueous ammonia to give trimesityltin hydroxide. This compound eliminates mesitylen and yields dimesityltin oxide. The product was investigated bv 13C NMR, mass spectroscopy and X-ray diffractions. Di-mesityltinoxide crystallizes in the space group P21/w with a = 25.38(1) Å, b = 12.525(5) Å, c= 32.91(1) Å, β= 91.37(3)° and two molecules in the asymmetric unit (Z=8). The R-factor is 0.049 for 4688 symmetry-independent reflections. The trimeric molecules have six-membered tin-oxygen heterocycles in a twist conformation.

Synthesis and Characterization of Imidazo[1,2-a]Pyrimidine

2015 ◽  
Vol 52 ◽  
pp. 1-4
Author(s):  
A.M. Shah ◽  
A.J. Rojivadiya
Keyword(s):  
Mass Spectroscopy ◽  
Synthesis And Characterization ◽  
Spectroscopic Techniques ◽  
One Pot ◽  
H Nmr ◽  
Ft Ir ◽  
C Nmr

An efficient protocol for the synthesis of imidazo [1,2-a] pyrimidine was developed by using three component one-pot Biginelli synthesis. The synthesized compounds were characterized by spectroscopic techniques like FT-IR, 1H NMR, 13C NMR, and mass spectroscopy.

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