Electrochemical and antioxidant properties of rutin

2010 ◽  
Vol 75 (5) ◽  
pp. 547-561 ◽  
Author(s):  
Martina Medvidović-Kosanović ◽  
Marijan Šeruga ◽  
Lidija Jakobek ◽  
Ivana Novak
Keyword(s):  
Electrochemical Oxidation ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Electrochemical Techniques ◽  
Antioxidant Properties ◽  
Differential Pulse ◽  
Oxidation Products ◽  
Trolox Equivalent Antioxidant Capacity ◽  
Carbon Electrode ◽  
Scan Rate

The mechanism of electrochemical oxidation of rutin on a glassy carbon electrode was studied at different pH by using several electrochemical techniques (cyclic, linear sweep, differential pulse and square-wave voltammetry) in order to give deeper insight into the mechanism of electrochemical oxidation of rutin and adsorption of its oxidation products on a glassy carbon electrode. It was determined that the rutin oxidation process on a glassy carbon electrode is reversible, pH dependent and includes the transfer of 2 e– and 2 H+. The products of electrochemical oxidation strongly adsorb on the electrode surface. Maximum surface coverage, Γmax, decreased with increasing scan rate from 3.4 × 10–9 mol cm–2 at scan rate 20 mV s–1 to 1.5 × 10–9 mol cm–2 at scan rate 100 mV s–1 and adsorption equilibrium constant was log K = 4.57 ± 0.05. Antioxidant properties of rutin were investigated by a Trolox equivalent antioxidant capacity (TEAC) assay. It was found that the TEAC values of rutin depend on concentration and the EC50 value of rutin amounted 0.23.

scholarly journals Electrochemical Oxidation of an Immunosuppressant, Mycophenolate Mofetil, and Its Assay in Pharmaceutical Formulations

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
S. N. Prashanth ◽  
K. C. Ramesh ◽  
J. Seetharamappa
Keyword(s):  
Mycophenolate Mofetil ◽  
Electrochemical Oxidation ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Limit Of Detection ◽  
Biological Fluids ◽  
Pharmaceutical Formulations ◽  
Differential Pulse ◽  
Carbon Electrode ◽  
Wide Ph Range

Electrochemical oxidation of mycophenolate mofetil (MMF) has been studied at a glassy carbon electrode in aqueous solution over a wide pH range. MMF was oxidized on glassy carbon electrode (GCE) by an irreversible process that was controlled mainly by diffusion. The irreversibility of the electrode process was verified by different criteria. A probable mechanism for electrochemical oxidation of MMF was proposed. Differential-pulse voltammogram of the drug showed two oxidation peaks at 0.631 V and at 0.921 V (verses SCE) in phosphate buffer of pH 6.0. This process could be used to determine MMF in the concentration range of5.0×10−7to7.5×10−4 M with a limit of detection of1.48×10−7 M. The method was successfully applied for the analysis of MMF in pure and dosage forms and in biological fluids.

scholarly journals L-ARGININE DETERMINATION IN BIOLOGICALLY ACTIVE ADDITIVE BY VOLTAMMETRY

2020 ◽  
Vol 63 (7) ◽  
pp. 4-9
Author(s):  
Valentina A. Popova ◽  
Maria N. Ponomareva ◽  
Elena I. Korotkova
Keyword(s):  
Differential Pulse Voltammetry ◽  
Dietary Supplement ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Differential Pulse ◽  
Biologically Active ◽  
Carbon Electrode ◽  
Scan Rate ◽  
Pulse Voltammetry

This article reports about the electrochemical determination of L-arginine on a glassy carbon electrode in a dietary supplement using anodic differential pulse voltammetry. The exponential depense of the peak current on the square root of the scan rate (I/v1/2), the shifts of the potential to the negative area and linear correlation between peak potential and logarithm of the scan rate (lg(v)) confirms that electrooxidation of L-arginine is an irreversible process. Moreover, the criteria of Semerano equals 0.4 may indicate the process of electrooxidation without adsorption. The effect of pH, accumulation potential, accumulation time and scan rate was tested on electrochemical behavior of L-arginine. Working conditions for L-arginine determination in model media are following: pH 13; Eacc 0.3 V, tacc 30 s; v = 60 mV s-1. A linear dependence of L-arginine electrooxidation current on its concentration was observed at the 0.9 V in the range between 1.0∙10-4 and 10∙10-4 mol l-1. The detection limit was 1.34∙10-6 mol l-1. A comparative determination of L-arginine in dietary supplement was carried out by the voltammetric method and capillary electrophoresis. Thus, the determination of L-arginine in a dietary supplement on a glassy carbon electrode in NaOH solution (pH 13) was successfully carried out using anodic differential pulse voltammetry. The proposed method does not require sample preparation and allows to quickly determine L-arginine in dietary supplement.

scholarly journals ELECTROCHEMICAL OXIDATION AND DETERMINATION OF AN ANTI-CANCER DRUG PEMETREXED DISODIUM

2017 ◽  
Vol 10 (3) ◽  
pp. 492
Author(s):  
Nagaraj P Shetti
Keyword(s):  
Electrochemical Oxidation ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Phosphate Buffer Solution ◽  
Cancer Drug ◽  
Carbon Electrode ◽  
Experimental Conditions ◽  
Anti Cancer ◽  
Scan Rate ◽  
Pemetrexed Disodium

Abstract-The electrochemical oxidation of an anti-cancer drug Pemetrexed disodium has been investigated at glassy carbon electrode using voltammetric techniques. The dependence of current on potential, pH, concentrartion, scan rate, and excipients were investigated to optimize the experimental conditions. According to the liner relation between peak potential, peak current, scan rate and Pemetrexed disodium concentration, differential pulse voltammetric method for the quantitative determination in phosphate Buffer solution was developed. The linear response was obtained in the range of 10 µM to 0.75 µM with a detection limit of 0.19 µM. The electrochemical oxidation of mechanism of an anti-cancer drug Pemetrexed disodium was proposed. Keywords- Pemetrexed disodium, Cyclic Voltammetry, Electochemical Studies, Glassy carbon electrode

Electrochemical Oxidation of Sanguinarine and of Its Oxidation Products at a Glassy Carbon Electrode - Relevance to Intracellular Effects

2009 ◽  
Vol 22 (1) ◽  
pp. 113-120 ◽  
Author(s):  
Victor Constantin Diculescu ◽  
Teodor Adrian Enache ◽  
Paulo Jorge Oliveira ◽  
Ana Maria Oliveira-Brett
Keyword(s):  
Electrochemical Oxidation ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Oxidation Products ◽  
Carbon Electrode

Electrochemical Oxidation of Berberine and of Its Oxidation Products at a Glassy Carbon Electrode

2009 ◽  
Vol 21 (9) ◽  
pp. 1027-1034 ◽  
Author(s):  
Victor C. Diculescu ◽  
Teodor Adrian Enache ◽  
Paulo J. Oliveira ◽  
Ana Maria Oliveira-Brett
Keyword(s):  
Electrochemical Oxidation ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Oxidation Products ◽  
Carbon Electrode

Sensitive Detection of Levocetirizine as a new Generation Antihistamine by Stripping Square Wave Voltammetry

2020 ◽  
Vol 16 (4) ◽  
pp. 424-437
Author(s):  
Kubra Ozturk ◽  
Nurgul K. Bakirhan ◽  
Sibel A. Ozkan ◽  
Bengi Uslu
Keyword(s):  
Electrochemical Sensor ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Differential Pulse ◽  
Real Sample ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Square Wave ◽  
Real Sample Analysis ◽  
Tablet Dosage

Background:: new and selective electrochemical sensor was developed for the determination of levocetirizine dihydrochloride, which is an antihistaminic drug. Method:: The investigation was performed by using cyclic, differential pulse and square wave voltammetric methods on the β-cyclodextrin modified glassy carbon electrode. It is thereby planned to obtain information about levocetirizine determination and its mechanism. Result:: The efficiency of experimental parameters including pH, scan rate, and accumulation potential and time on the anodic response of levocetirizine dihydrochloride was studied. By employing the developed method and under optimized conditions, the current showed linear dependence with a concentration in the range between 2 × 10-8 M and 6 × 10-6 M in pH 2.0 Britton Robinson (BR) buffer. Conclusion:: The achieved limits of detection and quantification were found as 3.73 × 10-10 M and 1.24 × 10-9 M, respectively. In addition, the possibility of applying the developed sensor for real sample analysis was investigated, so β-cyclodextrin modified glassy carbon electrode was used to determine levocetirizine dihydrochloride in Xyzal® tablet dosage form. Finally, this sensor was successfully applied to the real sample as a selective, simple, reproducible, repeatable electrochemical sensor.

Solar Exfoliated Graphene Oxide: A Platform for Electrochemical Sensing of Epinephrine

2020 ◽  
Vol 16 (4) ◽  
pp. 393-403 ◽  
Author(s):  
Renjini Sadhana ◽  
Pinky Abraham ◽  
Anithakumary Vidyadharan
Keyword(s):  
Cyclic Voltammetry ◽  
Graphene Oxide ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Simultaneous Detection ◽  
Differential Pulse ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Reduced Graphene ◽  
Pulse Voltammetry

Introduction: In this study, solar exfoliated graphite oxide modified glassy carbon electrode was used for the anodic oxidation of epinephrine in a phosphate buffer medium at pH7. The modified electrode showed fast response and sensitivity towards Epinephrine Molecule (EP). The electrode was characterized electrochemically through Cyclic Voltammetry (CV) and Differential Pulse Voltammetry (DPV). Area of the electrode enhanced three times during modification and studies reveal that the oxidation process of EP occurs by an adsorption controlled process involving two electrons. The results showed a detection limit of 0.50 ± 0.01μM with a linear range up to 100 μM. The rate constant calculated for the electron transfer reaction is 1.35 s-1. The electrode was effective for simultaneous detection of EP in the presence of Ascorbic Acid (AA) and Uric Acid (UA) with well-resolved signals. The sensitivity, selectivity and stability of the sensor were also confirmed. Methods: Glassy carbon electrode modified by reduced graphene oxide was used for the detection and quantification of epinephrine using cyclic voltammetry and differential pulse voltammetry. Results: The results showed an enhancement in the electrocatalytic oxidation of epinephrine due to the increase in the effective surface area of the modified electrode. The anodic transfer coefficient, detection limit and electron transfer rate constant of the reaction were also calculated. Conclusion: The paper reports the determination of epinephrine using reduced graphene oxide modified glassy carbon electrode through CV and DPV. The sensor exhibited excellent reproducibility and repeatability for the detection of epinephrine and also its simultaneous detection of ascorbic acid and uric acid, which coexist in the biological system.

scholarly journals Simultaneous electrochemical sensing of dihydroxy benzene isomers at cost-effective allura red polymeric film modified glassy carbon electrode

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Pattan-Siddappa Ganesh ◽  
Ganesh Shimoga ◽  
Seok-Han Lee ◽  
Sang-Youn Kim ◽  
Eno E. Ebenso
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Limit Of Detection ◽  
Tap Water ◽  
Differential Pulse ◽  
Oxidation Potential ◽  
Electrochemical Sensing ◽  
Carbon Electrode ◽  
Buffer Solution ◽  
Allura Red

Abstract Background A simple and simultaneous electrochemical sensing platform was fabricated by electropolymerization of allura red on glassy carbon electrode (GCE) for the interference-free detection of dihydroxy benzene isomers. Methods The modified working electrode was characterized by electrochemical and field emission scanning electron microscopy methods. The modified electrode showed excellent electrocatalytic activity for the electrooxidation of catechol (CC) and hydroquinone (HQ) at physiological pH of 7.4 by cyclic voltammetric (CV) and differential pulse voltammetric (DPV) techniques. Results The effective split in the overlapped oxidation signal of CC and HQ was achieved in a binary mixture with peak to peak separation of 0.102 V and 0.103 V by CV and DPV techniques. The electrode kinetics was found to be adsorption-controlled. The oxidation potential directly depends on the pH of the buffer solution, and it witnessed the transfer of equal number of protons and electrons in the redox phenomenon. Conclusions The limit of detection (LOD) for CC and HQ was calculated to be 0.126 μM and 0.132 μM in the linear range of 0 to 80.0 μM and 0 to 110.0 μM, respectively, by ultra-sensitive DPV technique. The practical applicability of the proposed sensor was evaluated for tap water sample analysis, and good recovery rates were observed. Graphical abstract Electrocatalytic interaction of ALR/GCE with dihydroxy benzene isomers.

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