scholarly journals ELECTROCHEMICAL OXIDATION AND DETERMINATION OF AN ANTI-CANCER DRUG PEMETREXED DISODIUM

2017 ◽  
Vol 10 (3) ◽  
pp. 492
Author(s):  
Nagaraj P Shetti
Keyword(s):  
Electrochemical Oxidation ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Phosphate Buffer Solution ◽  
Cancer Drug ◽  
Carbon Electrode ◽  
Experimental Conditions ◽  
Anti Cancer ◽  
Scan Rate ◽  
Pemetrexed Disodium

Abstract-The electrochemical oxidation of an anti-cancer drug Pemetrexed disodium has been investigated at glassy carbon electrode using voltammetric techniques. The dependence of current on potential, pH, concentrartion, scan rate, and excipients were investigated to optimize the experimental conditions. According to the liner relation between peak potential, peak current, scan rate and Pemetrexed disodium concentration, differential pulse voltammetric method for the quantitative determination in phosphate Buffer solution was developed. The linear response was obtained in the range of 10 µM to 0.75 µM with a detection limit of 0.19 µM. The electrochemical oxidation of mechanism of an anti-cancer drug Pemetrexed disodium was proposed. Keywords- Pemetrexed disodium, Cyclic Voltammetry, Electochemical Studies, Glassy carbon electrode

scholarly journals Sensitive Voltammetric Sensor for Tryptophan Detection by Using Polyvinylpyrrolidone Functionalized Graphene/GCE

Nanomaterials ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 125 ◽  
Author(s):  
Quanguo He ◽  
Jun Liu ◽  
Jinxia Feng ◽  
Yiyong Wu ◽  
Yaling Tian ◽  
...  
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Limit Of Detection ◽  
Phosphate Buffer Solution ◽  
Oxidation Mechanism ◽  
Carbon Electrode ◽  
Oxidation Peak ◽  
Experimental Conditions ◽  
Peak Current ◽  
Oxidation Peak Current

In this paper, an electrochemical method for the measurement of tryptophan (Trp) was developed based on a glassy carbon electrode modified with polyvinylpyrrolidonefunctionalized graphene (PVP-GR)/glassy carbon electrode (GCE). In 0.1 M phosphate buffer solution (PBS, pH = 2.2), compared with bare GCE, PVP/GCE, and GR/GCE, the oxidation peak current of Trp increased dramatically at PVP-GR/GCE. The oxidation mechanism of Trp on the PVP-GR/GCE was discussed and the experimental conditions were optimized. Under the best experimental conditions, the oxidation peak current of Trp was proportional to its concentration in the range of 0.06 µM–10.0 µM and 10.0–100.0 µM, and the limit of detection (LOD) was 0.01 µM (S/N = 3). The target modified electrode with excellent repeatability, stability and selectivity, was successfully applied to detectTrp in drugs and biological samples.

Electrochemical and antioxidant properties of rutin

2010 ◽  
Vol 75 (5) ◽  
pp. 547-561 ◽  
Author(s):  
Martina Medvidović-Kosanović ◽  
Marijan Šeruga ◽  
Lidija Jakobek ◽  
Ivana Novak
Keyword(s):  
Electrochemical Oxidation ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Electrochemical Techniques ◽  
Antioxidant Properties ◽  
Differential Pulse ◽  
Oxidation Products ◽  
Trolox Equivalent Antioxidant Capacity ◽  
Carbon Electrode ◽  
Scan Rate

The mechanism of electrochemical oxidation of rutin on a glassy carbon electrode was studied at different pH by using several electrochemical techniques (cyclic, linear sweep, differential pulse and square-wave voltammetry) in order to give deeper insight into the mechanism of electrochemical oxidation of rutin and adsorption of its oxidation products on a glassy carbon electrode. It was determined that the rutin oxidation process on a glassy carbon electrode is reversible, pH dependent and includes the transfer of 2 e– and 2 H+. The products of electrochemical oxidation strongly adsorb on the electrode surface. Maximum surface coverage, Γmax, decreased with increasing scan rate from 3.4 × 10–9 mol cm–2 at scan rate 20 mV s–1 to 1.5 × 10–9 mol cm–2 at scan rate 100 mV s–1 and adsorption equilibrium constant was log K = 4.57 ± 0.05. Antioxidant properties of rutin were investigated by a Trolox equivalent antioxidant capacity (TEAC) assay. It was found that the TEAC values of rutin depend on concentration and the EC50 value of rutin amounted 0.23.

scholarly journals A facile graphene oxide based sensor for electrochemical detection of prostate anti-cancer (anti-testosterone) drug flutamide in biological samples

RSC Advances ◽  
2017 ◽  
Vol 7 (41) ◽  
pp. 25702-25709 ◽  
Author(s):  
R. Karthik ◽  
Mani Govindasamy ◽  
Shen-Ming Chen ◽  
Tse-Wei Chen ◽  
J. Vinoth kumar ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Electrochemical Sensor ◽  
Electrochemical Detection ◽  
Glassy Carbon ◽  
Biological Samples ◽  
Cancer Drug ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Anti Cancer

An electrochemical sensor based on graphene oxide modified glassy carbon electrode for the determination of anti-cancer drug flutamide.

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