THU0065 Role of retinol binding protein 4 in insulin resistance of rheumatoid arthritis patients

Role of Retinol-Binding Protein 4 in Obese Asian Indians with Metabolic SyndromeRetinol-binding protein 4 is an adipocytokine separately implicated in the development of obesity-related insulin resistance and proatherogenic lipid profile, however, its role in humans is unclear. This study was carried out to assess the role of retinol-binding protein 4 as a potential marker of metabolic syndrome in obese Asian Indians (a high-risk population for diabetes). 52 obese (BMI >23 kg/m2) Asian Indians were grouped into those with and without metabolic syndrome based on IDF criteria and compared with healthy controls. The anthropometric and biochemical parameters (fasting blood sugar, lipid profile, serum insulin, high-sensitivity C-reactive protein, and retinol-binding protein 4) were estimated. The obese groups had significantly altered adiposity indices, insulin resistance parameters (fasting blood sugar (only in the metabolic syndrome group), serum insulin, HOMA-IR and QUICKI), index of inflammation (C-reactive protein) and proatherogenic dyslipidemic profile (serum triglycerides, VLDL-cholesterol, and triglyceride/HDL-cholesterol ratio). Retinol-binding protein 4 levels were elevated in the obese groups, but were not significant. Retinol-binding protein 4 levels were correlated with anthro-pometric parameters and atherogenic lipids, while C-reactive protein was correlated with anthropometric and insulin resistance parameters in the entire group of subjects. Although these correlations were not observed in the obese groups, in the control group, retinol-binding protein 4 was correlated to the lipid parameters and C-reactive protein to adiposity indices. Thus, the role of retinol-binding protein 4 as a potential marker of metabolic syndrome is limited to the prediction of proatherogenic risk among Asian Indians.

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Retinol-binding Protein 4 in Rheumatoid Arthritis-related Insulin Resistance and β-cell Function

The Journal of Rheumatology ◽

10.3899/jrheum.130834 ◽

2014 ◽

Vol 41 (4) ◽

pp. 658-665 ◽

Cited By ~ 6

Author(s):

Iván Ferraz-Amaro ◽

Miguel A. González-Gay ◽

Federico Diaz-González

Keyword(s):

Rheumatoid Arthritis ◽

Insulin Resistance ◽

Cell Function ◽

Binding Protein ◽

Retinol Binding Protein ◽

Β Cell ◽

C Peptide ◽

Retinol Binding Protein 4 ◽

Significant Difference ◽

Β Cell Function

Objective.Retinol-binding protein 4 (RBP4), an adipokine related to impaired glucose tolerance, has been associated with insulin resistance (IR) and β-cell function in subjects with obesity or diabetes. In our study we assessed RBP4 levels in patients with rheumatoid arthritis (RA). We also determined whether any correlation exists between RBP4 levels and the presence of IR in these patients.Methods.Plasma RBP4, insulin, C-peptide concentrations, and homeostasis model assessment (HOMA)-IR were measured in 101 patients with RA and 115 sex-matched and age-matched controls. A multivariable analysis adjusted for IR classic cardiovascular risk factors and body mass index was performed to establish the correlation between RBP4 plasma concentrations and features of IR in RA. Data were adjusted for glucocorticoid intake in patients with RA.Results.Patients had higher levels of insulin, C-peptide levels, HOMA-percentage of β-cell secretion (%B) index, and HOMA-IR index than controls. RBP4 levels were significantly lower in the whole group of patients than in controls [13.99 (9.78–19.88) vs 21.50 (10.28–32.59) μg/ml, p < 0.01]. However, only those who were glucocorticoid-naive showed significant difference in RBP4 plasma concentration when compared to controls [11.88 (7.93–17.96) vs 21.50 (10.28–32.59) μg/ml, p < 0.01]. The HOMA-%B [log β coefficient 0.00 (0.00–0.01), p < 0.01] showed positive relationships regarding RBP4 in controls. That was not the case in patients with RA [log β coefficient 0.00 (−0.0–0.00), p = 0.93 for HOMA-%B].Conclusion.RBP4 does not correlate with the presence of IR and β-cell function in patients with RA. The mechanisms leading to IR in RA may be different from those occurring in obesity or diabetes.

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Exploring the mediating role of serum retinol-binding protein 4 in the relationship between sleep quality and insulin resistance in pregnant women

Diabetes Research and Clinical Practice ◽

10.1016/j.diabres.2021.108866 ◽

2021 ◽

pp. 108866

Author(s):

Min Du ◽

Jue Liu ◽

Na Han ◽

Zhiling Zhao ◽

Shusheng Luo ◽

...

Keyword(s):

Insulin Resistance ◽

Sleep Quality ◽

Pregnant Women ◽

Binding Protein ◽

Retinol Binding Protein ◽

Serum Retinol ◽

Retinol Binding Protein 4 ◽

Mediating Role ◽

The Relationship

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Serum Retinol Binding Protein 4 Was Positively Associated with Insulin Resistance and Decreased after Laparoscopic Sleeve Gastrectomy in Chinese Obese Patients

Diabetes ◽

10.2337/db18-2455-pub ◽

2018 ◽

Vol 67 (Supplement 1) ◽

pp. 2455-PUB

Author(s):

XINGCHUN WANG ◽

LIANG LI ◽

CUILING ZHU ◽

JINGYANG GAO ◽

SHEN QU

Keyword(s):

Insulin Resistance ◽

Sleeve Gastrectomy ◽

Laparoscopic Sleeve Gastrectomy ◽

Binding Protein ◽

Retinol Binding Protein ◽

Obese Patients ◽

Serum Retinol ◽

Retinol Binding Protein 4

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Plasma retinol-binding protein 4 in the first and second trimester and risk of gestational diabetes mellitus in Chinese women: a nested case-control study

Nutrition & Metabolism ◽

10.1186/s12986-019-0425-9 ◽

2020 ◽

Vol 17 (1) ◽

Cited By ~ 1

Author(s):

Chuyao Jin ◽

Lizi Lin ◽

Na Han ◽

Zhiling Zhao ◽

Zheng Liu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Binding Protein ◽

First Trimester ◽

Retinol Binding Protein ◽

Second Trimester ◽

Retinol Binding Protein 4 ◽

Plasma Retinol

Abstract Background To assess the association between plasma retinol-binding protein 4 (RBP4) levels both in the first trimester and second trimester and risk of gestational diabetes mellitus (GDM). Methods Plasma RBP4 levels and insulin were measured among 135 GDM cases and 135 controls nested within the Peking University Birth Cohort in Tongzhou. Multivariable linear regression analysis was conducted to assess the influence of RBP4 levels on insulin resistance. Conditional logistic regression models were used to compute the odds ratio (OR) and 95% confidence interval (CI) between RBP4 levels and risk of GDM. Results The GDM cases had significantly higher levels of RBP4 in the first trimester than controls (medians: 18.0 μg/L vs 14.4 μg/L; P < 0.05). Plasma RBP4 concentrations in the first and second trimester were associated with fasting insulin, homeostasis model assessment for insulin resistance (HOMA-IR), and the quantitative insulin sensitivity check index (QUICKI) in the second trimester (all P < 0.001). With adjustment for diet, physical activity, and other risk factors for GDM, the risk of GDM increased with every 1-log μg/L increment of RBP4 levels, and the OR (95% CI) was 3.12 (1.08–9.04) for RBP4 in the first trimester and 3.38 (1.03–11.08) for RBP4 in the second trimester. Conclusions Plasma RBP4 levels both in the first trimester and second trimester were dose-dependently associated with increased risk of GDM.

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