AB0408 Increase of body mass index in a tight controlled methotrexate-based strategy with prednisone in early rheumatoid arthritis (CAMERA-II): Is it a side-effect of the prednisone or better control of disease activity?

Aim: To investigate the impact of body mass index (BMI) on clinical disease activity indices and clinical and sonographic remission rates in patients with rheumatoid arthritis (RA). Patients and Methods: Sixty-three patients with RA were categorized according to BMI score into three groups: normal (BMI<25), overweight (BMI 25-30) and obese (BMI≥30). Thirty-three of them were treated with conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs), and 30 with biologic DMARDs (bDMARDs). Patients underwent clinical and laboratory assessment and musculoskeletal ultrasound examination (MSUS) at baseline and at 6 months after initiation of therapy. We evaluated the rate of clinical and sonographic remission (defined as Power Doppler score (PD) = 0) and its correlation with BMI score. Results: In the csDMARDs group, 60% of the normal weight patients reached DAS28 remission; 33.3% of the overweight; and 0% of the obese patients. In the bDMARDs group, the percentage of remission was as follows: 60% in the normal weight subgroup, 33.3% in the overweight; and 15.8% in the obese. Within the csDMARDs treatment group, two significant correlations were found: BMI score–DAS 28 at 6th month, rs = .372, p = .033; BMI score–DAS 28 categories, rs = .447, p = .014. Within the bDMARDs group, three significant correlations were identified: BMI score–PDUS at sixth month, rs = .506, p =.004; BMI score–DAS 28, rs = .511, p = .004; BMI score–DAS 28 categories, rs = .592, p = .001. Sonographic remission rates at 6 months were significantly higher in the normal BMI category in both treatment groups. Conclusion: BMI influences the treatment response, clinical disease activity indices and the rates of clinical and sonographic remission in patients with RA. Obesity and overweight are associated with lower remission rates regardless of the type of treatment.

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Effect of Fatigue, Older Age, Higher Body Mass Index, and Female Sex on Disability in Early Rheumatoid Arthritis in the Treatment-to-Target Era

Arthritis Care & Research ◽

10.1002/acr.23281 ◽

2018 ◽

Vol 70 (3) ◽

pp. 361-368 ◽

Cited By ~ 5

Author(s):

Sarah Twigg ◽

Elizabeth M. A. Hensor ◽

Jane Freeston ◽

Ai Lyn Tan ◽

Paul Emery ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Body Mass Index ◽

Body Mass ◽

Early Rheumatoid Arthritis ◽

Older Age ◽

Female Sex

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Effect of Body Mass Index on the Disease Activity of Patients With Rheumatoid Arthritis in a Gender-Specific Manner and the Association of Respective Serum C-Reactive Protein Levels With the Body’s Inflammatory Status

Cureus ◽

10.7759/cureus.9417 ◽

2020 ◽

Author(s):

Shumaila M Iqbal ◽

Linda Burns ◽

Joseph Grisanti

Keyword(s):

Rheumatoid Arthritis ◽

Body Mass Index ◽

Disease Activity ◽

Body Mass ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Inflammatory Status ◽

Specific Manner ◽

Gender Specific

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Prevalence and Incidence of Metabolic Syndrome in a Cohort of Patients with Rheumatoid Arthritis: A Correlation between Body Mass Index and Disease Activity

Open Journal of Rheumatology and Autoimmune Diseases ◽

10.4236/ojra.2020.103012 ◽

2020 ◽

Vol 10 (03) ◽

pp. 95-108

Author(s):

Susana Ferreira Krampe ◽

Nicole Pamplona Bueno de Andrade ◽

Letícia Guimarães da Silveira ◽

Claiton Viegas Brenol

Keyword(s):

Rheumatoid Arthritis ◽

Metabolic Syndrome ◽

Body Mass Index ◽

Disease Activity ◽

Body Mass

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Association of Body Mass Index Categories with Disease Activity and Radiographic Joint Damage in Rheumatoid Arthritis: A Systematic Review and Metaanalysis

The Journal of Rheumatology ◽

10.3899/jrheum.150224 ◽

2015 ◽

Vol 42 (12) ◽

pp. 2261-2269 ◽

Cited By ~ 34

Author(s):

Celine Vidal ◽

Thomas Barnetche ◽

Jacques Morel ◽

Bernard Combe ◽

Claire Daïen

Keyword(s):

Rheumatoid Arthritis ◽

Systematic Review ◽

Body Mass Index ◽

Disease Activity ◽

Body Mass ◽

Health Assessment ◽

Joint Damage ◽

Overweight And Obesity ◽

Mean Difference ◽

Obese Patients

Objective.Obesity and overweight are increasing conditions. Adipose tissue with proinflammatory properties could be involved in rheumatoid arthritis (RA) activity and radiographic progression. This study aims to investigate the influence of overweight and obesity on RA activity and severity.Methods.We conducted a systematic review and metaanalysis to assess the association of body mass index (BMI) categories with the Disease Activity Score in 28 joints (DAS28), functional disability [Health Assessment Questionnaire (HAQ)], and radiographic joint damage in patients with RA. We searched Medline through PubMed, EMBASE, and the Cochrane Database of Systematic Reviews for all studies assessing DAS28, HAQ, or/and radiographic damage according to predefined BMI groups.Results.Among the 737 citations retrieved, 58 articles met the inclusion criteria and 7 were included in the metaanalysis. DAS28 was higher in obese (BMI > 30 kg/m2) than non-obese (BMI ≤ 30 kg/m2) patients (mean difference 0.14, 95% CI 0.01–0.27, p = 0.04, I2 = 0%). HAQ score was also higher among obese patients (mean difference 0.10, 95% CI 0.01–0.19, p = 0.03, I2 = 0%). Radiographic joint damage was negatively associated with obesity (standardized mean difference −0.15, 95% CI −0.29 to −0.02, p = 0.03, I2 = 38%).Conclusion.Obesity in RA is associated with increased DAS28 and HAQ score and with lower radiographic joint damage. These associations mainly result from an increase of subjective components of the DAS28 (total joint count and global health assessment) in obese patients. Conflicting results were reported concerning inflammation markers (C-reactive protein and erythrocyte sedimentation rate).

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