AB0823 Biochemical Markers of Bone Metabolism, Osteoprotegerin Serum Levels and Bone Mineral Density in Psoriatic Patients and their Relations to Disease Activity

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 1075.2-1075
Author(s):  
S.M. Rashad ◽  
H. Abozaid ◽  
H. Abozaid ◽  
M. Moneer ◽  
A. Sobhy
Keyword(s):  
Bone Mineral Density ◽  
Disease Activity ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Biochemical Markers ◽  
Serum Levels ◽  
Mineral Density

Effect of oxcarbazepine on bone mineral density and biochemical markers of bone metabolism in patients with epilepsy

2014 ◽  
Vol 108 (3) ◽  
pp. 442-447 ◽  
Author(s):  
Dae Lim Koo ◽  
Kyoung Jin Hwang ◽  
Suk Won Han ◽  
Ji Young Kim ◽  
Eun Yeon Joo ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Biochemical Markers ◽  
Mineral Density ◽  
Patients With Epilepsy

scholarly journals The influence of habitual salt intake on bone remodelling in young healthy people

2021 ◽  
pp. 1-10
Author(s):  
Erna Davidović-Cvetko ◽  
Anita Matić ◽  
Jasminka Milas-Ahić ◽  
Ines Drenjančević
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Biochemical Markers ◽  
Bone Remodelling ◽  
Sodium Intake ◽  
Healthy People ◽  
Type I ◽  
Mineral Density

Introduction: Sodium alters calcium metabolism by increasing calcium excretion, thus possibly influencing bone metabolism. The hypothesis of the present study is that amount of dietary sodium intake affects the bone remodelling. This study aimed to assess whether a habitual intake of sodium has an effect on peak bone mass and biochemical indicators of bone metabolism. Subjects and Methods: In a cross-sectional study that involved 41 young men and women, six biochemical markers were assessed from blood samples using ELISA: osteocalcin, C-terminal procollagen type I peptide, receptor activator kappa B ligand, pyridinoline, parathyroid hormone, and osteoprotegerin, while bone mineral density (BMD) and bone mineral content (BMC) were measured by dual x-ray absorptiometry. Subjects were divided into two groups according to habitual sodium intake (low-Na and high-Na group) assessed by questionnaire. Results: No difference was found between groups of low and high Na intake in BMD and BMC, or in biochemical markers of bone metabolism. Since the groups differed in Ca intake, energy and vitamin D, adjustments were made for those cofounders. Regression analysis showed that only the dietary intake of vitamin D was associated with dual femur BMD and BMC, and no correlation was found between bone remodelling indicators and Na intake after adjustment for vitamin D intake. Conclusion: The present results could not confirm that habitual sodium intake above recommended levels affects bone remodelling processes or decreases bone mineral density in young healthy people if combined with adequate calcium intake.

scholarly journals Relation between bone mineral density and IL-17 serum levels in Serbian patients with early Rheumatoid arthritis

Open Medicine ◽  
2014 ◽  
Vol 10 (1) ◽  
Author(s):  
Voja Pavlovic ◽  
Aleksandar Dimic ◽  
Sasa Milenkovic ◽  
Dane Krtinic ◽  
Ivana Aleksic
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Disease Activity ◽  
Bone Mineral ◽  
Serum Levels ◽  
Mineral Density ◽  
Serum Samples ◽  
Das28 Score ◽  
Early Ra ◽  
Control Serum

AbstractRheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial inflammation and destruction of joint cartilage and bone. Different cytokines play important role in the processes that cause articular destruction and extra-articular manifestations in RA. The contribution of cytokines representing the Th1 (INF-γ), Th2 (IL-4) and IL-17A to the pathogenesis of early RA and bone mineral density (BMD) loss in still poorly understood. Serum samples of 38 early RA patients were evaluated for erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), C-reactive protein (CRP), anti-cyclic citrullinated peptide antibodies (anti-CCP) and for the tested cytokines (IL-17A, IL-4 and INF-γ). BMD was evaluated by dualenergyX-ray absorptiometry (DXA). Disease activity score (DAS28) calculation was assessed for all patients. Control serum samples were obtained from 34 healthy volunteers. The levels of tested cytokines were significantly higher (IL-17A, p<0.001; INF-γ, P<0.001; IL-4, P<0.01) in patients with early RA, compared to the healthy controls. In early RA patients, strong correlation of serum IL-17A was found with DAS28, ESR and CRP. Also, a significant negative correlation was found between serum INF-γ levels and the DAS28 score. Significantly positive correlation of BMD values and CRP, DAS28 IL-17A were also demonstrated. DXA analysis revealed that the most common site for osteoporosis was the lumbar spine followed by the femoral neck. BMD values significantly correlated with CRP, DAS28 score and IL-17A serum levels. The mean serum IL-17A levels, in patients with early RA, corresponded with disease activity, severity and BMD loss, indicating the potential usefulness of serum IL-17A in defining the disease activity and bone remodeling.

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