Influence of oophorectomy on serum levels of sex steroids and bone metabolism and assessment of bone mineral density in lumbar trabecular bone by QCT-C value

10 Background: Several reports have showed that bone disorders occur after gastric cancer surgery, however there are few studies that compared pre- and postoperative bone mineral density of the same patient. The purpose of this study was to assess changes in bone metabolism after gastric cancer surgery prospectively. Methods: We prospectively enrolled 39 men undergoing gastrectomy for early gastric cancer. We excluded women to avoid the effect of menopause. Patients with severe kidney disease requiring dialysis treatment, patients with severe liver disease and patients with treatment with bisphosphonates or any other bone-active drugs were also excluded. Dual energy X-ray absorptiometry (DEXA) was performed before and 1 and 2 years after surgery to evaluate bone mineral density (BMD). The serum levels of 1,25-dihydroxy vitamin D (1,25(OH)2VD), 25-hydroxy vitamin D (25(OH)VD), estradiol, and alkaline phosphatase (ALP) were measured before surgery and every three months until two years after surgery. Results: DEXA revealed that BMD was significantly decreased by 0.036±0.033 g/cm2 at 12 months after gastrectomy (P < 0.001). The serum ALP was significantly increased by 38.88±6.42 IU/l at 24 months after surgery (P = 0.013), and there was a marginally significant correlation between the changes in BMD and the changes in the serum ALP at 24 months after surgery; the correlation coefficient was -0.30 (P = 0.090). The serum 25(OH)VD was significantly decreased by 4.88±6.42 ng/ml at 24 months after surgery (P < 0.001), however there was no significant correlation between the changes in BMD and the changes in the serum 25(OH)VD. The serum 1,25(OH)2VD and estradiol were not significantly changed before and after surgery. The factor significantly correlated to the reductions of BMD at 12 months after surgery included preoperative lower body mass index (BMI); the correlation coefficients was 0.37 (P = 0.025). Conclusions: This study showed a significant reduction in the BMD of gastric cancer patients at 12 months after gastrectomy and suggested that low preoperative BMI could be a high risk factor for the bone disorder after gastric cancer surgery.

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Evaluation of bone mineral density, bone metabolism, osteoprotegerin and receptor activator of the NF B ligand serum levels during treatment with infliximab in patients with rheumatoid arthritis

Annals of the Rheumatic Diseases ◽

10.1136/ard.2005.044198 ◽

2006 ◽

Vol 65 (11) ◽

pp. 1495-1499 ◽

Cited By ~ 148

Author(s):

M Vis ◽

E A Havaardsholm ◽

G Haugeberg ◽

T Uhlig ◽

A E Voskuyl ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Bone Mineral Density ◽

Bone Metabolism ◽

Bone Mineral ◽

Serum Levels ◽

Mineral Density ◽

Receptor Activator

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AB0823 Biochemical Markers of Bone Metabolism, Osteoprotegerin Serum Levels and Bone Mineral Density in Psoriatic Patients and their Relations to Disease Activity

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2014-eular.3358 ◽

2014 ◽

Vol 73 (Suppl 2) ◽

pp. 1075.2-1075

Author(s):

S.M. Rashad ◽

H. Abozaid ◽

M. Moneer ◽

A. Sobhy

Keyword(s):

Bone Mineral Density ◽

Disease Activity ◽

Bone Metabolism ◽

Bone Mineral ◽

Biochemical Markers ◽

Serum Levels ◽

Mineral Density

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OSOBENNOSTI METABOLIZMA KOSTNOY TKANI U BOL'NYKh ANKILOZIRUYuShchIM SPONDILOARTRITOM

Osteoporosis and Bone Diseases ◽

10.14341/osteo2011215-18 ◽

2011 ◽

Vol 14 (2) ◽

pp. 15-18

Author(s):

S A Yushina ◽

O V Bugrova ◽

N A Ovchinnikova ◽

I A Aleksandrova

Keyword(s):

Bone Mineral Density ◽

Bone Metabolism ◽

Bone Mineral ◽

Serum Levels ◽

Disease Stage ◽

Test Results ◽

Mineral Density ◽

Functional Index ◽

Bone Metabolism Markers ◽

X Ray

Objective: To define the specific features of bone metabolism and to estimate bone mineral density (BMD) in patients with ankylosing spondylitis (AS) Subjects and methods: Seventy-two patients (66 males and 6 females) with SA were examined. Markers of bone metabolism markers were assessed, by measuring the serum levels of osteocalcin (OC) and C-terminal telopeptides (bCrosslaps) by enzyme-linked immunoassay. Bone mineral density (BMD) was studied by distal forearm by dual-energy X-ray absorptiometry (DEXA) on a DexaScan DX-10 apparatus. BMD was estimated in women and men older 50 years by the T-test and in men under 50 years by the Z-test. Results: Low BMD was found by DEXA in 55% patients with SA., 7% patients had a vertebral fracture. The level of bCrosslaps was 0.52±0.37 ng/ml (p>0.05) and that of osteocalcin was 12,9±7,1 ng/ml (p<0.05), which is accordingly higher and lower than the reference values. With higher SA activity and advance of X-ray disease stage, there was a tendency for bCrosslaps to increase and osteocalcin to decrease. Correlation analysis revealed a correlation between the value of BMD and the SA activity, between the levels of OC and X-ray disease stage and functional index BASDAI., between the levels of bCrosslaps and degree of activity AS. Age and low physical activity also affected the parameters of BMD in patients with SA.

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