SAT0217 Axon Reflex Vasodilatation of Digital Arteries in Systemic Sclerosis Patients, Evaluated by Laser-Doppler Fluxmetry

2016 ◽  
Vol 75 (Suppl 2) ◽  
pp. 747.2-747
Author(s):  
C. Rotondo ◽  
M. Nivuori ◽  
A. Chialà ◽  
E. Praino ◽  
L. Coladonato ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Laser Doppler ◽  
Axon Reflex ◽  
Laser Doppler Fluxmetry

The NO release test as a functional reference standard for laser Doppler fluxmetry in cutaneous microangiology

2001 ◽  
Vol 7 (3) ◽  
pp. 172-175 ◽  
Author(s):  
Johannes Wohlrab ◽  
Ramona Körting ◽  
Peter Helmbold ◽  
Wolfgang Ch. Marsch
Keyword(s):  
Laser Doppler ◽  
Reference Standard ◽  
Laser Doppler Fluxmetry ◽  
Release Test ◽  
No Release

Early sign of microangiopathy in systemic sclerosis: The significance of cold stress test in dynamic laser Doppler flowmetry

2019 ◽  
Vol 71 (3) ◽  
pp. 373-378 ◽  
Author(s):  
Sebastian Yu ◽  
Stephen Chu-Sung Hu ◽  
Hsin-Su Yu ◽  
Yi-Ying Chin ◽  
Yang-Chun Cheng ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Cold Stress ◽  
Laser Doppler Flowmetry ◽  
Stress Test ◽  
Early Sign ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Cold Stress Test

Evaluation of Laser-Doppler-Fluxmetry for the diagnosis of microcirculatory disorders

2019 ◽  
Vol 71 (2) ◽  
pp. 129-135 ◽  
Author(s):  
C. Mrowietz ◽  
R.P. Franke ◽  
G. Pindur ◽  
R. Sternitzky ◽  
F. Jung ◽  
...  
Keyword(s):  
Laser Doppler ◽  
Laser Doppler Fluxmetry ◽  
Microcirculatory Disorders

Peripheral Blood Perfusion Correlates with Microvascular Abnormalities in Systemic Sclerosis: A Laser-Doppler and Nailfold Videocapillaroscopy Study

2010 ◽  
Vol 37 (6) ◽  
pp. 1174-1180 ◽  
Author(s):  
MAURIZIO CUTOLO ◽  
CARMELA FERRONE ◽  
CARMEN PIZZORNI ◽  
STEFANO SOLDANO ◽  
BRUNO SERIOLO ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Negative Correlation ◽  
Healthy Subjects ◽  
Blood Perfusion ◽  
Laser Doppler ◽  
Nailfold Videocapillaroscopy ◽  
Microvascular Damage ◽  
Local Skin ◽  
Doppler Flowmetry ◽  
Prostacyclin Analog

Objective.To investigate possible correlations between fingertip blood perfusion (FBP) status, assessed by laser Doppler flowmetry (LDF), and morphological microvascular abnormalities, detected by nailfold videocapillaroscopy (NVC), in patients with systemic sclerosis (SSc). The effects on FBP of intravenous (IV) treatment with the prostacyclin analog iloprost were also investigated.Methods.Thirty-four consecutive patients with SSc and 16 healthy subjects were evaluated. LDF was performed by analyzing blood perfusion at the fingertips in both hands. Patients with SSc were distributed into the appropriate NVC pattern of microangiopathy (early, active, and late). Iloprost was administered to inpatients with SSc by 24-hour IV infusion for 7 consecutive days (4 μg/h).Results.FBP was significantly lower in patients with SSc (p < 0.05) compared to controls. Heating of the LDF probe at 36°C induced a significant increase of FBP in all subjects (p < 0.001), but the slope of variation was significantly lower in patients with SSc compared to controls (p < 0.05). Patients with SSc showing the late NVC pattern of microangiopathy had significantly lower FBP than patients with the active and early NVC patterns (p < 0.05). A negative correlation was observed between FBP and NVC rating of the microvascular damage (p < 0.05). After iloprost treatment, a significant increase of FBP was observed in patients with SSc (p < 0.05).Conclusion.Patients with SSc show a decreased FBP partially reversible by local skin heating. The FBP correlated negatively with the extent of nailfold microvascular damage, and IV iloprost treatment increased the FBP.

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