FRI0005 The relationship between juvenile systemic lupus erythematosus and the transcription factors nf-kappab and ppar-gamma

We have explored the relationship between possible hemostatic changes and clinical manifestation of the systemic lupus erythematosus (SLE) as a function of greater or lesser disease activity according to Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2K) criteria. Endothelial injury and hypercoagulability were investigated in patients with SLE by measuring thrombomodulin (TM), D-dimer (DDi) and thrombin generation (TG) potential. A total of 90 participants were distributed into three groups: 1) women with SLE presenting with low disease activity (laSLE) (SLEDAI-2K ≤ 4), 2) women with SLE presenting with moderate to high disease activity (mhaSLE) (SLEDAI-2K > 4), and 3) a control group comprising healthy women. Levels of TM and DDi were higher both in the laSLE and mhaSLE groups compared to controls and in mhaSLE compared to the laSLE group. With respect to TG assay, lagtime and endogen thrombin potential, low concentrations of tissue factor provided the best results for discrimination among groups. Analysis of these data allow us to conclude that TM, DDi and TG are potentially useful markers for discriminating patients with very active from those with lower active disease. Higher SLE activity may cause endothelial injury, resulting in higher TG and consequently a hypercoagulability state underlying the picture of thrombosis common in this inflammatory disease.

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Association between academic performance and cognitive dysfunction in patients with juvenile systemic lupus erythematosus

Revista Brasileira de Reumatologia (English Edition) ◽

10.1016/j.rbre.2016.03.005 ◽

2016 ◽

Vol 56 (3) ◽

pp. 252-257

Author(s):

Renan Bazuco Frittoli ◽

Karina de Oliveira Peliçari ◽

Bruna Siqueira Bellini ◽

Roberto Marini ◽

Paula Teixeira Fernandes ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Academic Performance ◽

Cognitive Dysfunction ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Juvenile Systemic Lupus Erythematosus

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Juvenile systemic lupus erythematosus and dermatomyositis associated with urticarial vasculitis syndrome: a unique presentation

Rheumatology International ◽

10.1007/s00296-010-1484-4 ◽

2010 ◽

Vol 32 (11) ◽

pp. 3643-3646 ◽

Cited By ~ 6

Author(s):

Patrícia A. Macêdo ◽

Carolina B. Garcia ◽

Monique K. Schmitz ◽

Levi H. Jales ◽

Rosa M. R. Pereira ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Urticarial Vasculitis ◽

Juvenile Systemic Lupus Erythematosus

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Association of interleukin-2 and interferon-γ single nucleotide polymorphisms with Juvenile systemic lupus erythematosus

Allergologia et Immunopathologia ◽

10.1016/j.aller.2015.12.005 ◽

2016 ◽

Vol 44 (5) ◽

pp. 422-426 ◽

Cited By ~ 5

Author(s):

S. Harsini ◽

V. Ziaee ◽

F. Tahghighi ◽

M. Mahmoudi ◽

A. Rezaei ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Single Nucleotide Polymorphisms ◽

Lupus Erythematosus ◽

Interleukin 2 ◽

Interferon Γ ◽

Nucleotide Polymorphisms ◽

Systemic Lupus ◽

Juvenile Systemic Lupus Erythematosus ◽

Single Nucleotide

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Poor agreement of objectively measured and self-reported physical activity in juvenile dermatomyositis and juvenile systemic lupus erythematosus

Clinical Rheumatology ◽

10.1007/s10067-016-3234-9 ◽

2016 ◽

Vol 35 (6) ◽

pp. 1507-1514 ◽

Cited By ~ 8

Author(s):

Ana Jéssica Pinto ◽

Hamilton Roschel ◽

Fabiana Braga Benatti ◽

Ana Lúcia de Sá Pinto ◽

Adriana Maluf Elias Sallum ◽

...

Keyword(s):

Physical Activity ◽

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Juvenile Dermatomyositis ◽

Poor Agreement ◽

Systemic Lupus ◽

Juvenile Systemic Lupus Erythematosus ◽

Objectively Measured

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Serum Levels of MDC and MMP-9 and the Relationship Between Serum Levels and Disease Activity in the Patients with Systemic Lupus Erythematosus

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.314.7325 ◽

1969 ◽

Vol 31 (4) ◽

Cited By ~ 1

Author(s):

Yang Liu ◽

Tie Ning ◽

Li-Jie Bai

Keyword(s):

Systemic Lupus Erythematosus ◽

Disease Activity ◽

Lupus Erythematosus ◽

Serum Levels ◽

Systemic Lupus ◽

The Relationship

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The relationship of antiphospholipid antibodies to cognitive function in patients with systemic lupus erythematosus

Journal of the International Neuropsychological Society ◽

10.1017/s1355617797003779 ◽

1997 ◽

Vol 3 (4) ◽

pp. 377-386 ◽

Cited By ~ 101

Author(s):

SUSAN D. DENBURG ◽

RAMONA M. CARBOTTE ◽

JEFFREY S. GINSBERG ◽

JUDAH A. DENBURG

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Verbal Memory ◽

Lupus Anticoagulant ◽

Cognitive Test ◽

Antiphospholipid Antibody ◽

Systemic Lupus ◽

Cross Sectional ◽

Antibody Positivity ◽

The Relationship

Objective: To examine the relationship between antiphospholipid antibody positivity (expressed as the lupus anticoagulant) and cognitive dysfunction in patients with systemic lupus erythematosus (SLE). Methods: Cross-sectional comparisons of lupus anticoagulant (LA) positive (N = 39) and negative (N = 79) patients and controls (N = 35) on a cognitive test battery; 22 LA-positive and 53 LA-negative patients who had never experienced neuropsychiatric events (never-NP–SLE) were also compared separately. Results: LA-positive patients were 2 to 3 times more likely than were LA-negative patients to be designated as cognitively impaired. As a group, LA-positive patients, particularly those in the never-NP–SLE group, demonstrated lower performance primarily on tasks of verbal memory, cognitive flexibility, and psychomotor speed. Conclusions: LA positivity is associated with subclinical nervous system compromise, and a pattern of deficits compatible with subcortical involvement, possibly on the basis of ongoing LA-related microthrombotic events or vasculopathy. (JINS, 1997, 3, 377–386.)

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