AB0154 USAGE OF THE SARC-F QUESTIONNAIRE FOR SARCOPENIA SCREENING IN PATIENTS WITH RHEUMATOID ARTHRITIS

Background:Sarcopenia, characterized by low muscle strength and low muscle quantity or quality and associated with increased risks of falling and mortality. The prevalence of sarcopenia is 37% among patients with RA [1]. However, in clinical practice settings, sarcopenia among RA patients remains underdiagnosed. The SARC-F questionnaire [2] was recommended by the European Working Group on Sarcopenia in Older People (EWGSOP) before performing muscle strength tests and assessment muscle mass.Objectives:To evaluate the diagnostic value of the SARC-F questionnaire for the screening of sarcopenia (SP) in women with rheumatoid arthritis (RA).Methods:83 women (average age 59±8 years) with RA without aseptic bone necrosis, joint replacement and severe comorbidities were recruited. All patients were interviewed with the SARC-F questionnaire. The summation score ≥ 4 corresponded to cut-off for suspected sarcopenia. Sarcopenia was evaluated using the European Working Group on Sarcopenia in Older People (EWGSOP2), which included dual-energy X-ray absorptiometry (DXA), handgrip strength or chair stand test, and gait speed. The sensitivity, specificity, positive and negative prognostic values of the SARC-F questionnaire were estimated.Results:Confirmed SP was diagnosed in 20 (24%) RA patients, who had low muscle strength and mass. When conventional cut-off point (≥4) for SARC-F questionnaire was applied, only 30% of the patients with SP met this condition (sensitivity 30%, 95% confidence interval [95% CI] 13% to 54%), and 41% of the patients without SP did not meet this condition (specificity 41%, 95% CI 29% to 54%). Positive and negative prognostic values were 14% (95% CI 6% to 29%) and 65% (95% CI 48% to 79%), respectively.Conclusion:The SARC-F questionnaire alone is not adequate for screening of SP in RA patient. It is necessary to develop other simple screening methods that can easily be carried out in real clinical practice to identify individuals with possible SP for further diagnostic tests.References:[1]Torii M, Hashimoto M, Hanai A, et al. Prevalence and factors associated with sarcopenia in patients with rheumatoid arthritis. Modern Rheumatology, 2018;29(4):589-595. doi:10.1080/14397595.2018.1510565.[2]Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16-31. doi:10.1093/ageing/afy169.Disclosure of Interests:None declared

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Comparison between Original and Reviewed Consensus of European Working Group on Sarcopenia in Older People: A Probabilistic Cross-Sectional Survey among Community-Dwelling Older People

Gerontology ◽

10.1159/000519304 ◽

2021 ◽

pp. 1-8

Author(s):

Erik Ramirez ◽

Rogelio Salas ◽

Cristina Bouzas ◽

Rosario Pastor ◽

Josep A. Tur

Keyword(s):

Muscle Strength ◽

Older People ◽

Muscle Mass ◽

Working Group ◽

Handgrip Strength ◽

Community Dwelling ◽

Cross Sectional Survey ◽

Cross Sectional ◽

European Working Group ◽

European Working

Introduction: The European Working Group on Sarcopenia in Older People (EWGSOP) published a consensus on sarcopenia in 2010 and updated it in 2019 (EWGSOP2) which included the use of specific cut-off points. The aim was to assess how much prevalence of sarcopenia differed between EWGSOP2 and EWGSOP, as well as the use of specific cut-off points to assess differences in presarcopenia versus probable sarcopenia. Methods: Observational, transversal, and comparative study (n = 1,283 older adults; 57% women). Anthropometrics and handgrip strength were measured, and appendicular skeletal muscle mass equation was defined. Conceptual and methodological definitions of EWGSOP and EWGSOP2 consensus were applied to calculate prevalence of presarcopenia, probable sarcopenia, and sarcopenia. Results: Using cut-off points recommended for European population, prevalence of sarcopenia with EWGSOP2 was lower (−6.6%; p < 0.001) than EWGSOP. The prevalence of probable sarcopenia (EWGSOP2) was higher (+7.8%; p < 0.001) than EWGSOP presarcopenia. The agreement between EGWGSOP and EWGSOP2 was moderated (K = 0.45; IC = 0.40–0.51). Using specific-population cut-off points for muscle strength and appendicular muscle mass, the prevalence of probable sarcopenia with EWGSOP2 was higher (46.5%; p < 0.001) than EWGSOP (1.8%). The agreement between EGWGSOP and EWGSOP2 was moderated (K = 0.48; IC = 0.42–0.52). Conclusion: The new EWGSOP2 consensus underestimates the prevalence of sarcopenia, compared with EWGSOP using conventional cut-off points. The prevalence of presarcopenia with EWGSOP (low muscle mass) was lower than probable sarcopenia (low muscle strength) with the new EWGSOP2. In both cases, agreements between EWGSOP2 and EWGSOP were moderated. Discrepancies between the original and new consensus have implications on the primary health setting for identifying old and new cases for prevention and treatment.

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Sarcopenia and Liver Cirrhosis—Comparison of the European Working Group on Sarcopenia Criteria 2010 and 2019

Nutrients ◽

10.3390/nu12020547 ◽

2020 ◽

Vol 12 (2) ◽

pp. 547 ◽

Cited By ~ 3

Author(s):

Julia Traub ◽

Ina Bergheim ◽

Martin Eibisberger ◽

Vanessa Stadlbauer

Keyword(s):

Liver Cirrhosis ◽

Muscle Strength ◽

Diagnostic Criteria ◽

Muscle Mass ◽

Working Group ◽

Handgrip Strength ◽

Muscle Performance ◽

European Working Group ◽

European Working ◽

High Risk Populations

The European Working group on Sarcopenia in Older People recently updated the diagnostic criteria for sarcopenia. It is yet unclear how these modified criteria influence the rate of diagnosis in high risk populations, such as liver cirrhosis. We therefore assessed if the new diagnostic criteria for sarcopenia impacts on sarcopenia prevalence in liver cirrhosis. Within two years 114 cirrhotic patients were prospectively enrolled in the study. Sarcopenia was determined by muscle strength (handgrip strength), muscle mass (lumbal muscle index) and muscle performance (gait speed). Using the 2019 definition, the rate of pre-sarcopenia was significantly lower (30.7% versus 3.5%) due to the different starting points (2010 muscle mass, 2019 muscle strength) and cut-off values (muscle strength). The change in diagnostic criteria for sarcopenia drastically influences the rate of pre-sarcopenia diagnosis in cirrhotics. To evaluate, which diagnostic criteria should be chosen to diagnose sarcopenia in liver cirrhosis patients, prospective studies are needed.

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Muscle Strength Definitions Matter: Prevalence of Sarcopenia and Predictive Validity for Adverse Outcomes Using the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) Criteria

The journal of nutrition health & aging ◽

10.1007/s12603-020-1371-y ◽

2020 ◽

Vol 24 (6) ◽

pp. 614-618

Author(s):

Justin Chew ◽

A. Yeo ◽

S. Yew ◽

J. P. Lim ◽

L. Tay ◽

...

Keyword(s):

Muscle Strength ◽

Older People ◽

Predictive Validity ◽

Working Group ◽

Adverse Outcomes ◽

European Working Group ◽

European Working

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Comparison of two European Working Group on Sarcopenia in Older People (EWGSOP) handgrip strength cutoffs on a series of acute hip fracture patients

European Geriatric Medicine ◽

10.1016/j.eurger.2013.07.188 ◽

2013 ◽

Vol 4 ◽

pp. S57

Author(s):

R. Hoyos ◽

J.I. González-Montalvo ◽

T. Alarcón ◽

B. Pallardo ◽

P. Gotor ◽

...

Keyword(s):

Hip Fracture ◽

Older People ◽

Working Group ◽

Handgrip Strength ◽

European Working Group ◽

European Working

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POS0518 DIAGNOSTIC VALUE OF MUSCLE STRENGTH TESTS FOR THE DIAGNOSIS OF SARCOPENIA IN RHEUMATOID ARTHRITIS PATIENTS

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.1322 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 493.1-493

Author(s):

O. Dobrovolskaya ◽

A. Efremova ◽

N. Toroptsova ◽

O. Nikitinskaya ◽

A. Feklistov

Keyword(s):

Rheumatoid Arthritis ◽

Muscle Strength ◽

Diagnostic Accuracy ◽

Muscle Mass ◽

Handgrip Strength ◽

Diagnostic Value ◽

Predictive Values ◽

European Working ◽

Strength Tests ◽

Sensitivity Specificity

Background:Motor disorders in patients with rheumatoid arthritis (RA) may be associated with sarcopenia (SP). The frequency of secondary SP in RA patients reaches 17 - 37% [1, 2]. Currently, in patients with RA muscle strength is evaluated by methods proposed in geriatric practice [3].Objectives:To determine the sensitivity, specificity, diagnostic accuracy, positive and negative predictive value of handgrip strength (HS) and chair stand test (5-times sit-to-stand, CST) for the diagnosis of sarcopenia (SP) in women with rheumatoid arthritis (RA).Methods:87 women (aged 40-75 years) with RA were enrolled in the study. We did not include patients with aseptic bone necrosis, femoral and knee endoprostheses and comorbidity that negatively affected on the bone tissue. All patients underwent handgrip strength by mechanical dynamometer and CST. Handgrip strength less than 16 kg and CST more than 15 seconds were the criteria for probable SP. Assessment of muscle mass was carried out by dual-energy x-ray absorptiometry («Discovery A» Hologic, USA). Reduced muscle mass was determined as a decrease in appendicular muscle mass (AMM) < 15 kg or appendicular mass index (AMI) < 5.5 kg/m2. Confirmed SP was diagnosed when there was a combination of low muscle strength and reduced muscle mass. For both tests of muscle strength assessment, the sensitivity, specificity, diagnostic accuracy of the method, as well as their positive and negative predictor value for the diagnosis of SP were calculated.Results:Low handgrip strength and 5-times CST more than 15 seconds were found in 63 (72%) and 54 (62%) women, respectively. Among them only 20 (23%) patients had low AMM or AMI, so in these women SP was confirmed. For the handgrip strength the sensitivity of the method was 95%, and the specificity - only 34%, the diagnostic accuracy was 48%. The positive prognostic value of this test was 30%, and the negative value - 96%. The sensitivity, specificity and diagnostic accuracy of the CST were significantly lower than the handgrip strength and amounted to 50%, 21% and 28%, respectively. The prognostic value of this test, both positive (16%) and negative (58%), was also significantly lower than the assessment of handgrip strength in RA patients.We evaluated the diagnostic value of combination of two tests to identify individuals with probable SP: the sensitivity, specificity and diagnostic accuracy were 65%, 30% and 39%, respectively. Negative and positive predictive values were 71% and 24%, respectively, for combination of 2 tests, which was better than using only CST, but worse than using only hand dynamometry.Conclusion:Muscle strength tests proposed by the European Working Group on Sarcopenia in Older People have a low specificity, diagnostic accuracy and positive predictive values for detecting SP in RA patients, which requires the development of other methods of the first step of diagnosis of SP in RA patients.References:[1]Torii M, Hashimoto M, Hanai A, et al. Prevalence and factors associated with sarcopenia in patients with rheumatoid arthritis. Modern Rheumatology, 2018;29(4):589-595. doi:10.1080/14397595.2018.1510565[2]Vlietstra L, Stebbings S, Meredith-Jones K et al. Sarcopenia in osteoarthritis and rheumatoid arthritis: The association with self-reported fatigue, physical function and obesity. PLoS ONE, 2019;14(6):e0217462. doi:10.1371/journal.pone.0217462[3]Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16-31. doi:10.1093/ageing/afy169Disclosure of Interests:None declared

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Using the European Working Group on Sarcopenia in Older People (EWGSOP) definition to estimate the prevalence of sarcopenia in community dwelling older people in the uK: Findings from the Hertfordshire Cohort Study (HCS)

European Geriatric Medicine ◽

10.1016/j.eurger.2013.07.251 ◽

2013 ◽

Vol 4 ◽

pp. S76

Author(s):

H.P. Patel ◽

H.E. Syddall ◽

K.A. Jameson ◽

S.M. Robinson ◽

H.J. Denison ◽

...

Keyword(s):

Cohort Study ◽

Older People ◽

Working Group ◽

Community Dwelling ◽

European Working Group ◽

European Working ◽

Community Dwelling Older People ◽

Hertfordshire Cohort Study ◽

The Uk

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Prevalence of sarcopenia in community-dwelling older adults using the definition of the European Working Group on Sarcopenia in Older People 2: findings from the Korean Frailty and Aging Cohort Study

Age and Ageing ◽

10.1093/ageing/afz091 ◽

2019 ◽

Vol 48 (6) ◽

pp. 910-916 ◽

Cited By ~ 22

Author(s):

Miji Kim ◽

Chang Won Won

Keyword(s):

Older Adults ◽

Cohort Study ◽

Muscle Strength ◽

Older People ◽

Muscle Mass ◽

Working Group ◽

Community Dwelling ◽

European Working ◽

Definition Of ◽

Community Dwelling Older Adults

Abstract Background in October 2018, the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) updated their original definition of sarcopenia to reflect the scientific and clinical evidence that has accumulated over the last decade. Objective to determine the prevalence of sarcopenia in a large group of community-dwelling older adults using the EWGSOP2 definition and algorithm. Design a cross-sectional study. Setting the nationwide Korean Frailty and Aging Cohort Study (KFACS). Subjects a total of 2,099 ambulatory community-dwelling older adults, aged 70–84 years (mean age, 75.9 ± 4.0 years; 49.8% women) who were enrolled in the KFACS. Methods physical function was assessed by handgrip strength, usual gait speed, the five-times-sit-to-stand test, the timed up-and-go test, and the Short Physical Performance Battery. Appendicular skeletal muscle mass (ASM) was measured by dual-energy X-ray absorptiometry. Results according to the criteria of the EWGSOP2, the sarcopenia indicators of combined low muscle strength and low muscle quantity were present in 4.6–14.5% of men and 6.7–14.4% of women. The severe sarcopenia indicators of combined low muscle strength, low muscle quantity and low physical performance were present in 0.3–2.2% of men and 0.2–6.2% of women. Using the clinical algorithm with SARC-F as a screening tool, the prevalence of probable sarcopenia (2.2%), confirmed sarcopenia (1.4%) and severe sarcopenia (0.8%) was low. Conclusions the prevalence of sarcopenia among community-dwelling older individuals varied depending on which components of the revised EWGSOP2 definition were used, such as the tools used to measure muscle strength and the ASM indicators for low muscle mass.

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Agreement Between Initial and Revised European Working Group on Sarcopenia in Older People Definitions

Journal of the American Medical Directors Association ◽

10.1016/j.jamda.2018.11.026 ◽

2019 ◽

Vol 20 (3) ◽

pp. 382-383.e1 ◽

Cited By ~ 17

Author(s):

Steven Phu ◽

Sara Vogrin ◽

Jesse Zanker ◽

Ebrahim Bani Hassan ◽

Ahmed Al Saedi ◽

...

Keyword(s):

Older People ◽

Working Group ◽

European Working Group ◽

European Working

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Associação de força de preensão palmar e osteoporose avaliada por densitometria óssea (DXA) em idosos quilombolas

Acta Fisiátrica ◽

10.11606/issn.2317-0190.v25i4a163868 ◽

2018 ◽

Vol 25 (4) ◽

Author(s):

Luiz Sinésio Silva Neto ◽

Fabiane Aparecida Canaan Rezende ◽

Daniella Pires Nunes ◽

Erika Da Silva Maciel ◽

Andreia Travassos ◽

...

Keyword(s):

Older People ◽

Working Group ◽

European Working Group ◽

European Working

Objetivo: Verificar a associação de força de preensão palmar e osteoporose em idosos quilombolas. Método: Trata-se de um estudo seccional com 70 participantes (idade 65,58 ± 6.67 anos) de ambos os sexos. A densidade mineral óssea (DMO), massa muscular (MM) e o percentual de gordura foram analisados pela absortometria de raios-x de dupla energia (DXA) e a força de preensão palmar (FPP) por meio do dinamômetro de mão. O ponto de coorte adotado para identificação de osteoporose foi o da Organização Mundial de Saúde (OMS). A identificação do status da sarcopenia foi realizado para caraterização da amostra e para o diagnóstico foi utilizado os critérios propostos pelo European Working Group on Sarcopenia in Older People (EWGSOP). A FPP foi associada positivamente e significativamente com a DMO. Resultados: A osteopenia foi identificada em 42,8% da amostra e a osteoporose em 20%, sem diferença entre as frequências segundo o sexo (p = 0,161). Conclusão: Nos idosos quilombolas a baixa FPP esteve positivamente associada com baixa DMO. Portanto, sugerindo que a FPP pode ser considerada um fator de risco importante de estado ósseo em idosos quilombolas.

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