Corrective steps to enhance ventilation in the delivery room

2020 ◽  
Vol 105 (6) ◽  
pp. 605-608 ◽  
Author(s):  
Kesi C Yang ◽  
Arjan B te Pas ◽  
Danielle D Weinberg ◽  
Elizabeth E Foglia
Keyword(s):  
Heart Rate ◽  
Tidal Volume ◽  
Preterm Infants ◽  
Prospective Observational Study ◽  
Positive Pressure Ventilation ◽  
Outcome Measure ◽  
Delivery Room ◽  
Positive Pressure ◽  
Mouth Pressure ◽  
Before And After

ObjectiveThe clinical impact of ventilation corrective steps for delivery room positive pressure ventilation (PPV) is not well studied. We aimed to characterise the performance and effect of ventilation corrective steps (MRSOPA (Mask adjustment, Reposition airway, Suction mouth and nose, Open mouth, Pressure increase and Alternative airway)) during delivery room resuscitation of preterm infants.DesignProspective observational study of delivery room PPV using video and respiratory function monitor recordings.SettingTertiary academic delivery hospital.PatientsPreterm infants <32 weeks gestation.Main outcome measureMean exhaled tidal volume (Vte) of PPV inflations before and after MRSOPA interventions, categorised as inadequate (<4 mL/kg); appropriate (4–8 mL/kg), or excessive (>8 mL/kg). Secondary outcomes were leak (>30%) and obstruction (Vte <1 mL/kg), and infant heart rate.ResultsThere were 41 corrective interventions in 30 infants, with a median duration of 15 (IQR 7–29) s. The most frequent intervention was a combination of Mask/Reposition and Suction/Open. Mean Vte was inadequate before 16/41 interventions and became adequate following 6/16. Mean Vte became excessive after 6/41 interventions. Mask leak, present before 13/41 interventions, was unchanged after 4 and resolved after 9. Obstruction was present before five interventions and was subsequently resolved only once. MRSOPA interventions introduced leak in two cases and led to obstruction in one case. The heart rate was <100 beats per minute before 31 interventions and rose to >100 beats per minute after 14/31 of these.ConclusionsVentilation correction interventions improve tidal volume delivery in some cases, but lead to ineffective or excessive tidal volumes in others. Mask leak and obstruction can be induced by MRSOPA manoeuvres.

Impact of delivered tidal volume on the occurrence of intraventricular haemorrhage in preterm infants during positive pressure ventilation in the delivery room

2018 ◽  
Vol 104 (1) ◽  
pp. F57-F62 ◽  
Author(s):  
Qaasim Mian ◽  
Po-Yin Cheung ◽  
Megan O’Reilly ◽  
Samantha K Barton ◽  
Graeme R Polglase ◽  
...  
Keyword(s):  
Brain Injury ◽  
Tidal Volume ◽  
Preterm Infants ◽  
Positive Pressure Ventilation ◽  
Intraventricular Haemorrhage ◽  
Delivery Room ◽  
Positive Pressure ◽  
Reference Ranges ◽  
The Mean ◽  
Spontaneously Breathing

Background and objectivesDelivery of inadvertent high tidal volume (VT) during positive pressure ventilation (PPV) in the delivery room is common. High VT delivery during PPV has been associated with haemodynamic brain injury in animal models. We examined if VT delivery during PPV at birth is associated with brain injury in preterm infants <29 weeks’ gestation.MethodsA flow-sensor was placed between the mask and the ventilation device. VT values were compared with recently described reference ranges for VT in spontaneously breathing preterm infants at birth. Infants were divided into two groups: VT<6  mL/kg or VT>6 mL/kg (normal and high VT, respectively). Brain injury (eg, intraventricular haemorrhage (IVH)) was assessed using routine ultrasound imaging within the first days after birth.ResultsA total of 165 preterm infants were included, 124 (75%) had high VT and 41 (25%) normal VT. The mean (SD) gestational age and birth weight in high and normal VT group was similar, 26 (2) and 26 (1) weeks, 858 (251) g and 915 (250) g, respectively. IVH in the high VT group was diagnosed in 63 (51%) infants compared with 5 (13%) infants in the normal VT group (P=0.008).Severe IVH (grade III or IV) developed in 33/124 (27%) infants in the high VT group and 2/41 (6%) in the normal VT group (P=0.01).ConclusionsHigh VT delivery during mask PPV at birth was associated with brain injury. Strategies to limit VT delivery during mask PPV should be used to prevent high VT delivery.

scholarly journals 138 Mask or Nasal Tube to Provide Positive Pressure Ventilation (PPV) to Preterm Infants in the Delivery Room (DR)-The Mont Trial

2012 ◽  
Vol 97 (Suppl 2) ◽  
pp. A39-A39
Author(s):  
C. Kamlin ◽  
K. Schilleman ◽  
J. Dawson ◽  
E. Lopriore ◽  
S. Donath ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Positive Pressure Ventilation ◽  
Delivery Room ◽  
Positive Pressure ◽  
Nasal Tube

scholarly journals Extubation generates lung volume inhomogeneity in preterm infants

2021 ◽  
Author(s):  
R Bhatia ◽  
HR Carlisle ◽  
RK Armstrong ◽  
COF Kamlin ◽  
PG Davis ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Lung Volume ◽  
Neonatal Intensive Care ◽  
Electrical Impedance ◽  
Prospective Observational Study ◽  
Positive Pressure Ventilation ◽  
Positive Pressure ◽  
Impedance Tomography ◽  
Non Invasive ◽  
Volume Inhomogeneity

AbstractObjectiveTo evaluate the feasibility of EIT to describe the regional tidal ventilation (VT) and change in end-expiratory lung volume (EELV) patterns in preterm infants during the process of extubation from invasive to non-invasive respiratory support.DesignProspective observational studySettingSingle-centre tertiary neonatal intensive care unitPatientsPreterm infants born <32 weeks gestation who were being extubated to nasal continuous positive airway pressure (nCPAP) as per clinician discretion.InterventionsElectrical Impedance Tomography measurements were taken in supine infants during elective extubation from synchronised positive pressure ventilation (SIPPV) before extubation, during and then at 2 and 20 minutes after commencing nCPAP. Extubation and pressure settings were determined by clinicians.Main outcome measuresGlobal and regional ΔEELV and ΔVT were measured. Heart rate, respiratory rate and oxygen saturation were measured throughout.ResultsThirty infants of median (range) 2 (1, 21) days were extubated to a median (range) CPAP 7 (6, 8) cmH2O. SpO2/FiO2 ratio was mean (95% CI) 50 (35, 65) lower 20 minutes after nCPAP compared with SIPPV. EELV was lower at all points after extubation compared to SIPPV, and EELV loss was primarily in the ventral lung (p=0.04). VT was increased immediately after extubation, especially in the central and ventral regions of the lung, but the application of nCPAP returned VT to pre-extubation patterns.ConclusionsLung behaviour during the transition from invasive positive pressure ventilation to CPAP at moderate distending pressures is variable and associated with lung volume loss in the ventral lung.

scholarly journals Optimal Inspired Fraction of Oxygen in the Delivery Room for Preterm Infants

Children ◽  
2019 ◽  
Vol 6 (2) ◽  
pp. 29 ◽  
Author(s):  
Inmaculada Lara-Cantón ◽  
Alvaro Solaz ◽  
Anna Parra-Llorca ◽  
Ana García-Robles ◽  
Máximo Vento
Keyword(s):  
Oxygen Saturation ◽  
Preterm Infants ◽  
Respiratory System ◽  
Respiratory Insufficiency ◽  
Positive Pressure Ventilation ◽  
Relevant Literature ◽  
Delivery Room ◽  
Positive Pressure ◽  
Postnatal Adaptation

Postnatal adaptation of preterm infants entails a series of difficulties among which the immaturity of the respiratory system is the most vital. To overcome respiratory insufficiency, caregivers attending in the delivery room use positive pressure ventilation and oxygen. A body of evidence in relation of oxygen management in the delivery room has been accumulated in recent years; however, the optimal initial inspired fraction of oxygen, the time to achieve specific oxygen saturation targets, and oxygen titration have not been yet clearly established. The aim of this review is to update the reader by critically analyzing the most relevant literature.

Assisted ventilation immediately after birth with self-inflating bag versus T-piece resuscitator in preterm infants

2021 ◽  
pp. 1-6
Author(s):  
M. Khan ◽  
D. Bateman ◽  
R. Sahni ◽  
T.A. Leone
Keyword(s):  
Tidal Volume ◽  
Preterm Infants ◽  
Positive Pressure Ventilation ◽  
Controlled Trial ◽  
Assisted Ventilation ◽  
The Self ◽  
Target Range ◽  
Positive Pressure ◽  
Chi Square ◽  
Preterm Newborns

OBJECTIVE: To compare proportions of target range tidal volumes achieved with the self-inflating bag vs. the T-piece in resuscitation of preterm newborns at delivery. STUDY DESIGN: This randomized controlled trial was conducted at a tertiary Children’s Hospital. 20 preterm infants≤32 weeks’ gestational age with no congenital anomalies who needed positive pressure ventilation after birth were enrolled. Positive pressure ventilation was provided with the self-inflating bag or T-piece resuscitator. The primary outcome was proportion of inflations within a target range of 4–8 ml/kg. Chi-square and logistical regression analyses were performed. RESULTS: In the self-inflating bag (SIB) group 29% of inflations (117/419) and in the T-Piece (TP) group 51% of inflations (300/590) delivered expiratory tidal volume (TVe) of 4–8 ml/kg (p <  65.001). In the SIB group 60% of all inflations (254/419), and in the TP group 35% of all inflations (204/590) delivered TVe <  4 ml/kg (p <  0.001). In the SIB group 11% of all inflations (48/419), and in the TP group, 15% of all inflations (86/590) delivered TVe >  8 ml/kg (p = 0.18). The OR of having expiratory tidal volume of 4–8 ml/kg using the T-piece was 1.8 (CI 1.1–3.1), p = 0.02. CONCLUSION: Manual inflations provided by the TP deliver expiratory tidal volumes in the range of 4–8 ml/kg more consistently than SIB.

Effects of nasal positive-pressure hyperventilation on the glottis in normal awake subjects

1995 ◽  
Vol 79 (1) ◽  
pp. 176-185 ◽  
Author(s):  
V. Jounieaux ◽  
G. Aubert ◽  
M. Dury ◽  
P. Delguste ◽  
D. O. Rodenstein
Keyword(s):  
Tidal Volume ◽  
Positive Pressure Ventilation ◽  
Anterior Commissure ◽  
Minute Ventilation ◽  
Intermittent Positive Pressure Ventilation ◽  
Positive Pressure ◽  
Vocal Cords ◽  
Diaphragmatic Muscle ◽  
Inspiratory Resistance ◽  
Cyclic Changes

We have recently observed obstructive apneas during nasal intermittent positive-pressure ventilation (nIPPV) and suggested that they were due to hypocapnia-induced glottic closure. To confirm this hypothesis, we studied seven healthy subjects and submitted them to nIPPV while their glottis was continuously monitored through a fiber-optic bronchoscope. During wakefulness, we measured breath by breath the widest inspiratory angle formed by the vocal cords at the anterior commissure along with several other indexes. Mechanical ventilation was progressively increased up to 30 l/min. In the absence of diaphragmatic activity, increases in delivered minute ventilation resulted in progressive narrowing of the vocal cords, with an increase in inspiratory resistance and a progressive reduction in the percentage of the delivered tidal volume effectively reaching the lungs. Adding CO2 to the inspired gas led to partial widening of the glottis in two of three subjects. Moreover, activation of the diaphragmatic muscle was always associated with a significant inspiratory abduction of the vocal cords. Sporadically, complete adduction of the vocal cords was directly responsible for obstructive laryngeal apneas and cyclic changes in the glottic aperture resulted in waxing and waning of tidal volume. We conclude that in awake humans passive ventilation with nIPPV results in vocal cord adduction that depends partly on hypocapnia, but our results suggest that other factors may also influence glottic width.

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