Abstract
Objectives: Staphylococcus aureus could be considerable pathogenic bacterium because it can be changed from a microbiome to a lethal pathogen. Another remarkable ability of this bacterium is its colonization ability, which has been cloned in one-third of the world's population. Also, one of the most important issue in S. aureus is its severe resistance to antibiotics, which can lead to failure in antimicrobial therapy in many diseases such as abscesses, sinusitis, food poisoning, toxic shock syndrome, atopic dermatitis as well as it is one of the five major causes of nosocomial infections, especially post- surgical ulcers. therefore, find a novel antimicrobial target for S. aureus is crucial. Some studies demonstrated that toxin antitoxin systems can be the regulon for controlling the pathogenic bacteria. To identify the reliable antimicrobial targets, bioinformatics analysis before any experimental study could be helpful. Results: we evaluate the potent TA loci of 36 S. aureus strains by bioinformatics analysis. As regards, this analysis was performed with Rasta data base, toxin antitoxin systems distributions were seen in all scores and the htx-xre has the preponderance total frequency, which we hope will be beneficial for further researches.
Toxic shock syndrome associated arthropathy. Staphylococcus aureus: a further triggering event in reactive arthritis?
