scholarly journals Measurement of bone mineral density as an efficacy marker in denosumab treatment of giant cell tumour of bone

2017 ◽  
pp. bcr-2017-220369 ◽  
Author(s):  
Christian Veng ◽  
Peter Holmberg Jørgensen ◽  
Inger Krog-Mikkelsen ◽  
Maiken Stilling
2018 ◽  
pp. bcr-2018-225095
Author(s):  
Duarte Rosa ◽  
Raquel Baptista Dias ◽  
João Cunha Salvador ◽  
Alexandra Borges

We report the case of a 74-year-old man with a giant cell tumour (GCT) of the right maxilla and pterygoid process. The patient presented to the maxillofacial and head and neck surgery clinic with an ulcerated lesion of the hard palate. Initial workup with CT revealed a mass within the right maxillary sinus and pterygoid process with associated bone expansion and erosion. Biopsy showed a GCT with mucosal ulceration. Two years after surgical resection, a follow-up CT revealed tumour recurrence involving the right pterygoid process and lateral pterygoid muscle. The patient was then proposed for therapy with denosumab. Under denosumab treatment, the lesion maintained stable dimensions and became sclerotic and heavily ossified.


2019 ◽  
Vol 34 (6) ◽  
pp. 1033-1040 ◽  
Author(s):  
S Ferrari ◽  
C Libanati ◽  
Celia Jow Fang Lin ◽  
JP Brown ◽  
F Cosman ◽  
...  

2019 ◽  
Vol 112 (11) ◽  
pp. 472-475 ◽  
Author(s):  
Manuel Sosa Henríquez ◽  
María Jesús Gómez de Tejada Romero ◽  
María Escudero-Socorro ◽  
Oscar Torregrosa Suau

Summary A significant loss of bone mineral density and the appearance of multiple vertebral fractures after discontinuation of denosumab treatment have been described. To date, no hip fractures have been reported. We present three cases of patients who suffered femoral fractures after denosumab suppression.


2018 ◽  
Vol 95 (1120) ◽  
pp. 106-107 ◽  
Author(s):  
Shuzhong Liu ◽  
Xi Zhou ◽  
An Song ◽  
Zhen Huo ◽  
Yipeng Wang ◽  
...  

2017 ◽  
Vol 36 (4) ◽  
pp. 431-438 ◽  
Author(s):  
Takeshi Mochizuki ◽  
Koichiro Yano ◽  
Katsunori Ikari ◽  
Kosei Kawakami ◽  
Ryo Hiroshima ◽  
...  

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