scholarly journals Atypical presentation of progressive young onset dementia

2018 ◽  
Vol 11 (1) ◽  
pp. bcr-2018-225754 ◽  
Author(s):  
Bushra Elhusein ◽  
Ahmed Radwan ◽  
Abdalla Khairi ◽  
Mohamed Ahmed
Keyword(s):  
Brain Mri ◽  
Poor Response ◽  
Final Diagnosis ◽  
Subcortical White Matter ◽  
Alzheimer’S Dementia ◽  
Alzheimer's Dementia ◽  
Young Onset ◽  
Early Onset Dementia ◽  
Young Onset Dementia ◽  
Loss Of Appetite

We present the case of a 34-year-old Jordanian woman who was referred to mainstream mental health services because of irritability, agitation, loss of appetite, withdrawal from family activities and sleeping difficulties. She was initially diagnosed with major depressive disorder but subsequently showed very poor response to antidepressant therapy. Her presentation gradually and dramatically progressed into full blown dementia within couple of years. Brain MRI showed atrophic cortical changes and subcortical white matter alterations consistent with Alzheimer’s dementia. Brain PET scan revealed reduction in cerebral glucose metabolism in temporoparietal areas bilaterally most consistent with Alzheimer’s dementia. There was a strong family history of early-onset dementia. A final diagnosis of young onset dementia was made, and unfortunately, she passed away at the age of 44 years.

O3-13-06: Targeted re-sequencing of sorl1 in early-onset Alzheimer's dementia: The european early onset dementia consortium

2015 ◽  
Vol 11 (7S_Part_5) ◽  
pp. P253-P253
Author(s):  
Kristel Sleegers ◽  
Jan Verheijen ◽  
Julie van der Zee ◽  
Karolien Bettens ◽  
Sebastiaan Engelborghs ◽  
...  
Keyword(s):  
Early Onset ◽  
Alzheimer’S Dementia ◽  
Alzheimer's Dementia ◽  
Early Onset Dementia

scholarly journals Young-Onset Dementia with Lewy Bodies

2018 ◽  
Vol 10 (3) ◽  
pp. 363-368
Author(s):  
Yosuke Aiba ◽  
Ryuji Sakakibara ◽  
Tsuyoshi Ogata ◽  
Ayako Iimura ◽  
Keiichiro Terayama ◽  
...  
Keyword(s):  
Dementia With Lewy Bodies ◽  
Brain Mri ◽  
Correct Diagnosis ◽  
Lewy Bodies ◽  
Rem Sleep Behavior Disorder ◽  
Brain Perfusion ◽  
Imaging Features ◽  
Sleep Behavior ◽  
Young Onset ◽  
Young Onset Dementia

Young-onset (< 65 years) dementia is a challenging clinical problem. A 61-year-old man visited our clinic because of a 2-year history of mild cognitive impairment of the executive disorder type. He was initially suspected of having young-onset Alzheimer’s disease due to the lack of motor signs or hippocampal atrophy by conventional brain MRI. However, he proved to have anosmia, erectile dysfunction, hypersexuality, constipation, REM sleep behavior disorder, and emotional lability; imaging findings included positive brain perfusion SPECT, nigrosome MRI, DAT scan, and MIBG myocardial scintigraphy. All these clinical imaging features led to the correct diagnosis of young-onset dementia with Lewy bodies (YOD-DLB). It is hoped that this case report will help facilitate a future prospective study to diagnose and follow YOD-DLB patients with the aim of determining appropriate management and care.

scholarly journals Research protocol of the NeedYD-study (Needs in Young onset Dementia): a prospective cohort study on the needs and course of early onset dementia

2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Deliane van Vliet ◽  
Christian Bakker ◽  
Raymond TCM Koopmans ◽  
Myrra JFJ Vernooij-Dassen ◽  
Frans RJ Verhey ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Early Onset ◽  
Prospective Cohort ◽  
Research Protocol ◽  
Young Onset ◽  
Early Onset Dementia ◽  
Young Onset Dementia

scholarly journals A Comparative Analysis of Structural Brain MRI in the Diagnosis of Alzheimer’s Disease

2009 ◽  
Vol 21 (1-2) ◽  
pp. 13-19 ◽  
Author(s):  
Jason Appel ◽  
Elizabeth Potter ◽  
Qian Shen ◽  
Gustavo Pantol ◽  
Maria T. Greig ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Medial Temporal Lobe ◽  
Rating Scales ◽  
Brain Mri ◽  
Alzheimer’S Dementia ◽  
Alzheimer's Dementia ◽  
Increased Risk

Dementia is a debilitating and life-altering disease which leads to both memory impairment and decline of normal executive functioning. While causes of dementia are numerous and varied, the leading cause among patients 60 years and older is Alzheimer’s disease. The gold standard for Alzheimer’s diagnosis remains histological identification of amyloid plaques and neurofibrillary tangles within the medial temporal lobe, more specifically the entorhinal cortex and hippocampus. Although no definitive cure for Alzheimer's disease currently exists, there are treatments targeted at preserving cognition and memory while delaying continued loss of function. Alzheimer's disease exists along a spectrum of cognitive decline and is often preceded by Mild Cognitive Impairment (MCI). Patients with MCI demonstrate memory loss and cognitive impairment while still continuing normal activities of daily living, and are considered to be at increased risk for developing Alzheimer's Dementia. Identifying patients with prodromal states of Alzheimer's dementia such as MCI may allow initiation of appropriate treatment planning and delay of cognitive decline. Therefore, the need for a non-invasive early biomarker for the detection of Alzheimer's disease has never been greater. Multiple neuroimaging methods utilizing visual rating scales, volumetric measurements, and automated methods have been developed to identify, quantify, and track anatomic sequelae of Alzheimer’s Disease.

Serum and cerebrospinal fluid cystatin C levels in vascular and Alzheimer's dementia

2000 ◽  
Vol 101 (4) ◽  
pp. 279-282 ◽  
Author(s):  
J. Kalman ◽  
J. Marki-Zay ◽  
A. Juhasz ◽  
A. Santha ◽  
L. Dux ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Cystatin C ◽  
Alzheimer’S Dementia ◽  
Alzheimer's Dementia
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