scholarly journals Acute arthritis, skin rash and Lofgren’s syndrome

2021 ◽  
Vol 14 (6) ◽  
pp. e239239
Author(s):  
Ajay Chauhan ◽  
Aditya Jandial ◽  
Kundan Mishra ◽  
Rajeev Sandal
Keyword(s):  
Skin Lesions ◽  
The Body ◽  
Cutaneous Lesions ◽  
Acute Arthritis ◽  
Hilar Lymphadenopathy ◽  
Ocular Manifestations ◽  
Bilateral Hilar Lymphadenopathy ◽  
Löfgren’S Syndrome ◽  
Granulomatous Disorder ◽  
Classical Triad

Sarcoidosis is an autoimmune multisystem granulomatous disorder of unknown aetiology, which mainly affects the adults in the age group of 20–39 years. The disease can affect any organ in the body but mainly presents as bilateral hilar lymphadenopathy, pulmonary infiltrates, cutaneous lesions, ocular manifestations and arthropathy. Lofgren’s syndrome is an uncommon initial presentation of sarcoidosis which is recognised by the classical triad of acute arthritis, erythema nodosum and bilateral hilar lymphadenopathy. We describe a newly diagnosed case of sarcoidosis who presented as Lofgren’s syndrome. Acute sarcoid arthritis should be kept as one of the differential diagnoses for patients presenting with acute arthritis and skin lesions; and chest X-ray should be considered to rule out bilateral hilar lymphadenopathy in these patients. Early suspicion and identification of classical clinical features are essential to establish early diagnosis.

Invasive cutaneous cryptococcosis of the nasal planum in a cat – case report

2018 ◽  
Vol XXIII (133) ◽  
pp. 56-62
Author(s):  
Ana Cláudia Balda ◽  
Juliana Cristina Gonçalves ◽  
Renata Cristina Menezes ◽  
Ana Cristina Fascetti de Souza ◽  
Guilherme Durante Cruz
Keyword(s):  
Private Practice ◽  
Infectious Agent ◽  
Skin Lesions ◽  
The Body ◽  
Small Animals ◽  
Cutaneous Lesions ◽  
Mixed Breed ◽  
Deep Mycosis ◽  
The City ◽  
Cutaneous Cryptococcosis

Crytococcosis is the most common deep mycosis in cats, despite its rarity in the medical practice of small animals. The infectious agent of the disease is Cryptococcus sp, an opportunistic fungus that can spread throughout the body. An approximately two-year-old mixed breed cat, weighting 3 kg was presented to a private practice in the city of São Paulo, Brazil. Physical examination relealed pyogranulomatous skin lesions, mainly on the nasal planum and the second digit of the left thoracic lim. The animal presented no neurological or respiratory signs. The response to antifulgal on cutaneous lesions was favorable, but the animal did not resist a second sedation and died within twenty-eight days after starting treatment. This report shows an atypical case of cryptococcosis due to the lack of immunodeficiency.

scholarly journals Extensive Lepromatous Lymphadenitis Preceding Lesions on the Face and Earlobes: An Unusual Presentation of Leprosy in Singapore

2018 ◽  
Vol 10 (1) ◽  
pp. 35-40
Author(s):  
Shi Yao Sam Yang ◽  
Wai Mun Sean Leong ◽  
Cruz Maria Teresa Kasunuran ◽  
Jing Xiang Huang ◽  
Sue-Ann Ju Ee Ho ◽  
...  
Keyword(s):  
Early Stage ◽  
Developed Countries ◽  
Skin Lesions ◽  
The Body ◽  
The Other ◽  
Cutaneous Lesions ◽  
Poor Countries ◽  
Geographical Regions ◽  
Resource Poor ◽  
The Face

Leprosy is also known as Hansen disease, as in some countries the diagnosis of leprosy carries a negative stigma and patients fear being shunned as outcasts. Presently, leprosy is primarily limited to specific geographical regions in resource-poor countries. As a result, there is increased difficulty for the younger generation of physicians today to correctly identify leprosy due to a lack of exposure and a low-index of suspicion, particularly in developed countries. In this case, the indurated lesions over the face demonstrated a preference for the outer lateral aspects over the maxillary areas, the nose bridge, and the pinna of the ears consistent with the organism’s preference for cooler regions of the body. This was also evident in the other skin lesions affecting the more acral regions of the limbs in the early stage of disease progression. There is a need to keep this infective condition as an alternate diagnosis to all unusual cutaneous lesions.

scholarly journals Regional variations in antigenic properties of skin. A possible cause for disease-specific distribution of skin lesions.

1986 ◽  
Vol 164 (6) ◽  
pp. 2125-2130 ◽  
Author(s):  
L Sison-Fonacier ◽  
J C Bystryn
Keyword(s):  
Regional Differences ◽  
Skin Diseases ◽  
Pemphigus Vulgaris ◽  
Skin Lesions ◽  
The Body ◽  
Cutaneous Lesions ◽  
Specific Distribution ◽  
Antigenic Properties ◽  
Possible Cause ◽  
Disease Specific

The possibility that the distribution of skin lesions in some cutaneous diseases is due to variations in the antigenic properties of skin was investigated by mapping the expression of the skin-specific pemphigus vulgaris and bullous pemphigoid antigens in different regions of the body. The expression of both antigens was relatively stable within the same region, but varied between regions in a pattern that was distinct for each antigen. For each antigen there was a correlation between regions of high expression and location of skin lesions in autoimmune diseases involving the antigen. The results indicate that there are marked regional differences in the antigenic properties of skin and suggest this may influence the distribution of cutaneous lesions in some skin diseases.

scholarly journals Lofgren syndrome: Acute Variant of Sarcoidosis, A case report

KYAMC Journal ◽  
2013 ◽  
Vol 2 (1) ◽  
pp. 145-148
Author(s):  
M Nure Alom Siddiqui ◽  
Muhammad Afsar Siddiqui ◽  
Shahnaj Sultana
Keyword(s):  
Case Report ◽  
Erythema Nodosum ◽  
Hilar Lymphadenopathy ◽  
Bilateral Hilar Lymphadenopathy ◽  
Löfgren Syndrome ◽  
Löfgren’S Syndrome ◽  
Acute Form

Lofgren's syndrome is an acute form of sarcoidosis that is characterized by erythema nodosum (EN), bilateral hilar lymphadenopathy (BHL) accompanied by arthritis or arthralgia. We are reporting a 32 year old male with Lofgren's syndrome and then the literature is reviewed. Keywords: lofgren's syndrome, sarcoidosis.DOI: http://dx.doi.org/10.3329/kyamcj.v2i1.13520 KYAMC Journal Vol.2(1) 2011 pp.145-148

scholarly journals A Systematic Review of Clinical Studies on Mucocutaneous Manifestations of COVID-19: Virus-Related and Drug-Related

2021 ◽  
Author(s):  
Elham Behrangi ◽  
Mohammadreza Ghassemi ◽  
Afsaneh Sadeghzadeh-Bazargan ◽  
Masoumeh Roohaninasab ◽  
Niloufar Najar Nobari ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Symptoms ◽  
Skin Lesions ◽  
The Body ◽  
Inclusion Criteria ◽  
Cutaneous Lesions ◽  
Drug Induced ◽  
Skin Biopsies ◽  
Dermatologic Manifestations ◽  
Primary Skin Lesions

Coronavirus could affect almost any part of the body including the skin. In this systematic review, the primary skin lesions resulting from the direct activity of the virus or the medications used for treatment and the changes in the behavior of the virus regarding the occurrence of these symptoms over time were assessed. PubMed/MEDLINE, Embase, PsycINFO, TRIP Cochrane, Cochrane Skin were searched for all published articles from February 19 to July 1, 2020, which met the inclusion criteria. Thirty-six related articles were extracted. Twenty-eight studies reported virus-related mucocutaneous eruptions and 8 articles, the drug-reactions. Data of 583 patients were included. Skin lesions of COVID-19 could be caused by both the virus itself or the influence of drugs used for the treatment. Morbilliform rashes, urticaria, and acral-vasculopathic cutaneous lesions were at the forefront of primary COVID-dependent skin lesions with no significant change during time, Also, Hydroxychloroquine, lopinavir/ritonavir, paracetamol, and antibiotics were reported as the main causes of drug-induced rashes. Since dermatologic manifestations may occur prior or simultaneously/after other COVID clinical symptoms, so they may helpful in patients’ early diagnosis or prediction of internal organ involvements via histopathologic evaluations of skin biopsies especially about vasculopathic and vasculitic, respectively.

scholarly journals Mixed Phenotype Acute Leukemia Presenting as Leukemia Cutis

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Geetha Narayanan ◽  
M. T. Sugeeth ◽  
Lali V. Soman
Keyword(s):  
Bone Marrow ◽  
Acute Leukemia ◽  
Bone Marrow Aspiration ◽  
Skin Lesions ◽  
The Body ◽  
Leukemic Cells ◽  
Monocytic Differentiation ◽  
Cutaneous Lesions ◽  
Congenital Leukemia ◽  
Leukemia Cutis

Leukemia cutis (LC) is defined as infiltration of the skin by leukemic cells resulting in clinically recognizable cutaneous lesions. It is common in congenital leukemia and acute myeloid leukemia. However, LC has rarely been reported with mixed phenotypic acute leukemia (MPAL). We report the case of a lady who presented with erythematous papular and nodular lesions all over the body. Skin biopsy showed leukemic infiltration and bone marrow aspiration showed MPAL of the T/myeloid with monocytic differentiation lineage. This is the first report of an adult patient with MPAL of the T/myeloid with monocytic differentiation type presenting with leukemia cutis. She was started on chemotherapy with Hyper-CVAD. There is complete resolution of the skin lesions and she has achieved bone marrow remission after the first cycle of chemotherapy.

scholarly journals First Report of Two Cases of Löfgren’s Syndrome after SARS-CoV-2 Vaccination-Coincidence or Causality?

Vaccines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1313
Author(s):  
Jan-Gerd Rademacher ◽  
Björn Tampe ◽  
Peter Korsten
Keyword(s):  
Clinical Improvement ◽  
Erythema Nodosum ◽  
De Novo ◽  
Temporal Association ◽  
Hilar Lymphadenopathy ◽  
First Report ◽  
Bilateral Hilar Lymphadenopathy ◽  
Löfgren’S Syndrome ◽  
Acute Form ◽  
Chronic Course

Sarcoidosis can present as an acute form or take a chronic course. One of the acute presentations is Löfgren’s syndrome (LS), consisting of the symptom triad of bilateral hilar lymphadenopathy, erythema nodosum, and ankle periarthritis. In addition, there are occasional reports of sarcoid-like reactions following drug exposures. Nevertheless, reports of sarcoidosis or LS after vaccination have not been published. Here, we report two cases of de novo LS in a temporal association with different vaccines against the new coronavirus SARS-CoV-2. One patient developed the first symptoms three days after the second vaccination (first vaccination ChadOx-1, Astra Zeneca; second vaccination CX-024414, Moderna); in the second patient, symptoms started 28 days after the first vaccination (ChadOx-1, Astra Zeneca). Both patients eventually required treatment with glucocorticoids. Both patients achieved clinical improvement with treatment. In conclusion, we report the first two cases of LS shortly after SARS-CoV-2 vaccination.

Bilateral ankle pain secondary to sarcoidosis

1989 ◽  
Vol 79 (3) ◽  
pp. 116-120
Author(s):  
M Julsrud
Keyword(s):  
Young Adults ◽  
Erythema Nodosum ◽  
Unknown Etiology ◽  
Foot And Ankle ◽  
Ankle Pain ◽  
Hilar Lymphadenopathy ◽  
Bilateral Hilar Lymphadenopathy ◽  
Symptom Complex ◽  
Granulomatous Disorder

Sarcoidosis has been described as a multisystem granulomatous disorder of unknown etiology that usually affects young adults. It can affect the foot and ankle. When erythema nodosum is present, the sarcoidosis usually is characterized by bilateral hilar lymphadenopathy, uveitis, fever, arthralgia, or arthritis. This symptom complex is referred to as Löfgren's syndrome. The author describes a patient who presented with bilateral medial ankle pain secondary to sarcoidosis.

Sarcoidosis

2007 ◽  
pp. 227-230
Keyword(s):  
Erythema Nodosum ◽  
Specific Treatment ◽  
Rare Condition ◽  
Medical Setting ◽  
Inflammatory Disorder ◽  
Hilar Lymphadenopathy ◽  
Bilateral Hilar Lymphadenopathy ◽  
Löfgren’S Syndrome

Sarcoidosis 228 Known diagnosis of sarcoid 228 Sarcoidosis is a multisystem inflammatory disorder of unknown cause. It is a relatively rare condition (UK incidence 5–10 in 100 000) and so it is unusual for it to present in the acute medical setting. Acute sarcoid, previously undiagnosed, may present as Löfgren's syndrome, a combination of erythema nodosum, bilateral hilar lymphadenopathy on the CXR, fever, and arthralgia. This requires no specific treatment (other than simple analgesics or NSAIDs for arthralgia/pain from erythema nodosum) and has an excellent prognosis; the majority will resolve completely within 1–2 years....

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