scholarly journals Extensive Lepromatous Lymphadenitis Preceding Lesions on the Face and Earlobes: An Unusual Presentation of Leprosy in Singapore

2018 ◽  
Vol 10 (1) ◽  
pp. 35-40
Author(s):  
Shi Yao Sam Yang ◽  
Wai Mun Sean Leong ◽  
Cruz Maria Teresa Kasunuran ◽  
Jing Xiang Huang ◽  
Sue-Ann Ju Ee Ho ◽  
...  
Keyword(s):  
Early Stage ◽  
Developed Countries ◽  
Skin Lesions ◽  
The Body ◽  
The Other ◽  
Cutaneous Lesions ◽  
Poor Countries ◽  
Geographical Regions ◽  
Resource Poor ◽  
The Face

Leprosy is also known as Hansen disease, as in some countries the diagnosis of leprosy carries a negative stigma and patients fear being shunned as outcasts. Presently, leprosy is primarily limited to specific geographical regions in resource-poor countries. As a result, there is increased difficulty for the younger generation of physicians today to correctly identify leprosy due to a lack of exposure and a low-index of suspicion, particularly in developed countries. In this case, the indurated lesions over the face demonstrated a preference for the outer lateral aspects over the maxillary areas, the nose bridge, and the pinna of the ears consistent with the organism’s preference for cooler regions of the body. This was also evident in the other skin lesions affecting the more acral regions of the limbs in the early stage of disease progression. There is a need to keep this infective condition as an alternate diagnosis to all unusual cutaneous lesions.

Invasive cutaneous cryptococcosis of the nasal planum in a cat – case report

2018 ◽  
Vol XXIII (133) ◽  
pp. 56-62
Author(s):  
Ana Cláudia Balda ◽  
Juliana Cristina Gonçalves ◽  
Renata Cristina Menezes ◽  
Ana Cristina Fascetti de Souza ◽  
Guilherme Durante Cruz
Keyword(s):  
Private Practice ◽  
Infectious Agent ◽  
Skin Lesions ◽  
The Body ◽  
Small Animals ◽  
Cutaneous Lesions ◽  
Mixed Breed ◽  
Deep Mycosis ◽  
The City ◽  
Cutaneous Cryptococcosis

Crytococcosis is the most common deep mycosis in cats, despite its rarity in the medical practice of small animals. The infectious agent of the disease is Cryptococcus sp, an opportunistic fungus that can spread throughout the body. An approximately two-year-old mixed breed cat, weighting 3 kg was presented to a private practice in the city of São Paulo, Brazil. Physical examination relealed pyogranulomatous skin lesions, mainly on the nasal planum and the second digit of the left thoracic lim. The animal presented no neurological or respiratory signs. The response to antifulgal on cutaneous lesions was favorable, but the animal did not resist a second sedation and died within twenty-eight days after starting treatment. This report shows an atypical case of cryptococcosis due to the lack of immunodeficiency.

On the Measurement of the Palate in Idiots and Imbeciles

1876 ◽  
Vol 22 (98) ◽  
pp. 196-201 ◽  
Author(s):  
T. Claye Shaw
Keyword(s):  
Prima Facie ◽  
The Body ◽  
The Other ◽  
General Idea ◽  
Cranial Sutures ◽  
High Arched Palate ◽  
Other Hand ◽  
The Face

There is a general idea expressed in text-books, and more or less freely asserted in practice, but which I shall prove to be a fallacy, that a high-arched palate is so frequently met with in idiocy and imbecility that it may be taken as a sign of their existence. Indeed, when a case of this kind is brought forward the patient is made to open his mouth, under the conviction that a high palate will be found as certainly as a superficial alteration of the tongue in gastric disturbance. We shall see that the connection is an accidental one; and there is, in reality, no relationship between the development of the intellect and the height and width of the palate. If we consider that the bones of the cranium are developed in a different manner from those of the face, and that ossification at the base is complete long before that of the bones forming the palate, it is clear that there can be no primâ facie reason for thinking that because a person has an imperfect brain he should therefore have an imperfect palate; yet such an interdependence is held. It is quite true that a constitutional taint, such as rickets or syphilis, which affects the ossification of the bones generally and the cranial sutures, would probably affect the palatine bones, and hence it is that many idiots and imbeciles are found to have high or imperfect palates: but on the other hand some modifying taint may dwarf the height of the body, may affect the shape of the head to such an extent as to make an idiot of the microcephalic type, and yet leave the palate untouched, perfect in all conditions of width, height, number, quality, and regularity of teeth.

scholarly journals Mucocutaneous Ulcerations and Pancytopenia due to Methotrexate Overdose

2016 ◽  
Vol 8 (3) ◽  
pp. 287-293 ◽  
Author(s):  
Katharina Knoll ◽  
Florian Anzengruber ◽  
Antonio Cozzio ◽  
Lars E. French ◽  
Carla Murer ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Early Stage ◽  
Skin Lesions ◽  
Bone Marrow Suppression ◽  
Cutaneous Lesions ◽  
Neoplastic Diseases ◽  
Immune Mediated

Methotrexate (MTX) is an antifolic drug used in the treatment of immune-mediated and neoplastic diseases. Initiation or dosage changes in MTX therapy can cause mucositis and bone marrow suppression. Skin lesions due to acute MTX toxicity are rare, but they serve as a herald for later-onset pancytopenia. Therefore, identification of those cutaneous lesions might help to initiate rescue strategies at an early stage. Here we describe a case with mucocutaneous ulcerations and pancytopenia due to overdosed MTX.

Severe Ulcerative and Granulomatous Pinnal Lesions with Granulomatous Sebaceous Adenitis in Unrelated Vizslas

2011 ◽  
Vol 47 (6) ◽  
pp. 455-460 ◽  
Author(s):  
Gila Zur ◽  
Ana-Maria Botero-Anug
Keyword(s):  
Cyclosporin A ◽  
Otitis Externa ◽  
Skin Lesions ◽  
The Body ◽  
The Other ◽  
Sebaceous Adenitis

Granulomatous sebaceous adenitis (GSA) is uncommon in dogs; however, certain breed predilections exist. In this report, three cases of GSA in unrelated vizslas have been described. All cases initially presented with episodes of otitis externa followed by severe inner pinnal lesions. In one case, multifocal coalescing inner pinnal ulceration appeared 4 wk prior to the occurrence of the skin lesions. The other two cases presented with simultaneous pinnal and skin lesions following episodes of bilateral otitis. The pinnae were diffusely erythematous and had multiple coalescing erosions and ulcers. The body lesions consisted of multifocal alopecia, papules, and fine scales. Biopsies of the skin and pinnae confirmed GSA. Two dogs responded to treatment with synthetic retinoids and cyclosporin A, respectively. One dog was not treated, and the owners preferred euthanasia when the ear lesions recurred and did not respond to glucocorticoids. To the best of the authors’ knowledge, GSA with multifocal coalescing ulcerative pinnal lesions has not previously been reported.

scholarly journals Interpretability of a Deep Learning Based Approach for the Classification of Skin Lesions into Main Anatomic Body Sites

Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 6048
Author(s):  
Joanna Jaworek-Korjakowska ◽  
Andrzej Brodzicki ◽  
Bill Cassidy ◽  
Connah Kendrick ◽  
Moi Hoon Yap
Keyword(s):  
Deep Learning ◽  
Malignant Melanoma ◽  
Skin Lesions ◽  
The Body ◽  
Anatomic Site ◽  
The Past ◽  
Depth Analysis ◽  
The Face

Over the past few decades, different clinical diagnostic algorithms have been proposed to diagnose malignant melanoma in its early stages. Furthermore, the detection of skin moles driven by current deep learning based approaches yields impressive results in the classification of malignant melanoma. However, in all these approaches, the researchers do not take into account the origin of the skin lesion. It has been observed that the specific criteria for in situ and early invasive melanoma highly depend on the anatomic site of the body. To address this problem, we propose a deep learning architecture based framework to classify skin lesions into the three most important anatomic sites, including the face, trunk and extremities, and acral lesions. In this study, we take advantage of pretrained networks, including VGG19, ResNet50, Xception, DenseNet121, and EfficientNetB0, to calculate the features with an adjusted and densely connected classifier. Furthermore, we perform in depth analysis on database, architecture, and result regarding the effectiveness of the proposed framework. Experiments confirm the ability of the developed algorithms to classify skin lesions into the most important anatomical sites with 91.45% overall accuracy for the EfficientNetB0 architecture, which is a state-of-the-art result in this domain.

scholarly journals Regional variations in antigenic properties of skin. A possible cause for disease-specific distribution of skin lesions.

1986 ◽  
Vol 164 (6) ◽  
pp. 2125-2130 ◽  
Author(s):  
L Sison-Fonacier ◽  
J C Bystryn
Keyword(s):  
Regional Differences ◽  
Skin Diseases ◽  
Pemphigus Vulgaris ◽  
Skin Lesions ◽  
The Body ◽  
Cutaneous Lesions ◽  
Specific Distribution ◽  
Antigenic Properties ◽  
Possible Cause ◽  
Disease Specific

The possibility that the distribution of skin lesions in some cutaneous diseases is due to variations in the antigenic properties of skin was investigated by mapping the expression of the skin-specific pemphigus vulgaris and bullous pemphigoid antigens in different regions of the body. The expression of both antigens was relatively stable within the same region, but varied between regions in a pattern that was distinct for each antigen. For each antigen there was a correlation between regions of high expression and location of skin lesions in autoimmune diseases involving the antigen. The results indicate that there are marked regional differences in the antigenic properties of skin and suggest this may influence the distribution of cutaneous lesions in some skin diseases.

Evaluation of Performance of Reused HIVCHEK 1 + 2 Test Blocks which have Shown Negative Result: A Reliable Method for Rural Hospital?

1995 ◽  
Vol 25 (2) ◽  
pp. 54-55
Author(s):  
Geoffrey Larry Acaye ◽  
Luca Ansaloni ◽  
Egidio Tocalli
Keyword(s):  
Predictive Value ◽  
Reliable Method ◽  
Blood Donors ◽  
The Other ◽  
Diagnostic Purpose ◽  
Diagnostic Systems ◽  
Poor Countries ◽  
Hiv Surveillance ◽  
Evaluation Of Performance ◽  
Resource Poor

The performance of the reusing of test membranes which have been used previously for negative tests for the detection of antibody to HIV (HIVCHEK 1 +2 of Ortho Diagnostic Systems, Paris, France) was evaluated under field conditions. The sensitivity and specificity of the reusing strategy compared with a HIV determination obtained by using new HIVCHECK 1+2 tests were 89.1% and 100%, respectively. The positive predictive value was 100% and the negative predictive value was 91.5%. The authors conclude that the reduction in sensitivity of the reusing strategy in comparison with the use of new tests makes this strategy ethically unacceptable for the detection of HIV infection in blood donors. On the other hand, the reusing strategy could be very useful for diagnostic purpose and for epidemiological HIV surveillance in resource-poor countries.

scholarly journals XXIII. Of the nerves which associate the muscles of the chest, in the actions of breathing, speaking, and expression. Being a continuation of the paper on the structure and functions of the nerves

1822 ◽  
Vol 112 ◽  
pp. 284-312 ◽  
Keyword(s):  
The Body ◽  
The Other ◽  
The Face ◽  
Voluntary Motion ◽  
The One ◽  
Structure And Functions

In a former paper an examination was made of the nerves of the face; that part of the system was taken, as proving in a manner the least liable to exception, that two sets of nerves, hitherto undistinguished, possessed distinct powers; and that very different effects were produced when the muscles and integuments were deprived of the controuling influence of the one or of the other of these nerves. In that paper it was shown, that parts remote in situation, were yet united by the closest sympathy with the lungs. That by a division of one nerve, these organs could be severed from the other parts of the apparatus of respiration; and though rendered dead to the influence of the heart and lungs, were yet possessed of their other properties, such as sensibility and voluntary motion. In the present paper it is proposed to prosecute this sub­ject, by tracing the nerves which influence the motions of the trunk of the body in respiration, and to subject them to a similar enquiry.

A Case of Imbecility with Choreoid Movements

1887 ◽  
Vol 33 (142) ◽  
pp. 254-259
Author(s):  
Fletcher Beach ◽  
Darenth Asylum
Keyword(s):  
Scarlet Fever ◽  
The Body ◽  
The Other ◽  
Mental Condition ◽  
Maternal Grandfather ◽  
The Face ◽  
The One

F. P., aged 17, was admitted May 17th, 1875, with the following history:—Parents healthy, temperate, not connected by consanguinity. His maternal grandfather and a cousin on the mother's side are paralyzed. He is the eldest of six children, of whom two are dead, one succumbing from scarlet fever, the other soon after birth. The rest are healthy. His mental condition is said to have been good up to the age of ten years, when, during a fight with a boy, he was struck with a key in the face. Disease of the jaw followed, and on recovery he was noticed not to be so bright, having been a good scholar before. Twelve months afterwards he was knocked down and became insensible, and some months after he fell and struck the back of his head. He has been getting gradually duller. Four years ago he had an epileptic fit, affecting both sides of the body. He was taken to the Hospital for Epilepsy and Paralysis, and, while there, had two fits. He became excitable and tried to stab a patient, and his removal became necessary. After he was taken out of the hospital he became quiet for a time, but the excitability reappeared. He was taken to the Hampstead Asylum, and subsequently removed to the one at Clapton.

scholarly journals Case Report: Acute hemorrhagic edema of infancy (Seidlmayer purpura) – a dramatic presentation for a benign disease

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1771
Author(s):  
Elena Carboni ◽  
Maria Scavone ◽  
Ettore Stefanelli ◽  
Valentina Talarico ◽  
Stefania Zampogna ◽  
...  
Keyword(s):  
Leukocytoclastic Vasculitis ◽  
Skin Lesions ◽  
Rapid Onset ◽  
Cutaneous Lesions ◽  
Laboratory Findings ◽  
Distinct Disease ◽  
The Face ◽  
Clinical Conditions ◽  
Dramatic Presentation ◽  
Schonlein Purpura

We present a case of an 11-month-old girl who was referred to our unit for an erythematous rash that appeared on the face and extremities. Personal and family history was not relevant. Laboratory tests were normal. During recovery, diameter and colour intensity of the cutaneous lesions increased, but after some weeks, lesions had a self-limited resolution without any treatment. Based on clinical and laboratory findings, a diagnosis of acute hemorrhagic edema of infancy (AHEI) was made.  AHEI is a rare cutaneous leukocytoclastic vasculitis that usually affects children aged between 4 and 24 months. Etiology is unknown but almost of 75% of cases are preceded by infectious episodes, vaccinations or use of medications. In contrast to the dramatic cutaneous eruption, clinical conditions are usually optimal. Classically, AHEI is characterized by a triad of symptoms: fever, edema and purpura. Skin lesions are erythematous, annular, medallion-like, purpuric plaques that have a rapid onset and appear on the face and extremities, sparing trunk and mucosal membranes. Initially interpreted as a variant of Henoch-Schönlein purpura, now it is considered a distinct disease. In the majority of cases the disease is benign and self-limited without a visceral involvement, so a conservative approach is most often chosen.

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