Placental polyp with arteriovenous malformation treated with a gonadotoropin-releasing hormone antagonist

A 35-year-old woman (gravida 1, para 0) underwent termination of pregnancy (ToP) at 12 weeks of gestation. One month after ToP, she experienced significant vaginal bleeding and the mass with blood flow was identified on imaging. The presence of a placental polyp with arteriovenous malformation (AVM) was suspected on transvaginal sonography and MRI. Since the bleeding had ceased when she visited our hospital, we decided to treat the placental polyp with AVM with gonadotropin-releasing hormone (GnRH) antagonist therapy instead of surgery. Two months after GnRH antagonist treatment, the mass and blood flow in the uterus disappeared. Menstruation resumed 1 month after the completion of treatment. In our case, we were able to successfully treat placental polyps with AVM using GnRH antagonist therapy.

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The gonadotropin-releasing hormone (GnRH) agonist-induced initial rise of bioactive LH and testosterone can be blunted in a dose-dependent manner by GnRH antagonist in the non-human primate

Urological Research ◽

10.1007/bf00922743 ◽

1992 ◽

Vol 20 (5) ◽

pp. 317-321 ◽

Cited By ~ 10

Author(s):

O. P. Sharma ◽

G. F. Weinbauer ◽

H. M. Behre ◽

E. Nieschlag

Keyword(s):

Gnrh Agonist ◽

Gnrh Antagonist ◽

Gonadotropin Releasing Hormone ◽

Dependent Manner ◽

Releasing Hormone ◽

Initial Rise ◽

Dose Dependent ◽

Human Primate

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Orchidectomy selectively increases follicle-stimulating hormone secretion in gonadotropin-releasing hormone antagonist-treated male rats

Acta Endocrinologica ◽

10.1530/eje.0.1320357 ◽

1995 ◽

Vol 132 (3) ◽

pp. 357-362 ◽

Cited By ~ 4

Author(s):

M Tena-Sempere ◽

L Pinilla ◽

E Aguilar

Keyword(s):

Gnrh Antagonist ◽

Follicle Stimulating Hormone ◽

Hormone Secretion ◽

Gonadotropin Releasing Hormone ◽

Male Rats ◽

Gonadotropin Secretion ◽

Releasing Hormone ◽

Treated Male ◽

Lh Secretion ◽

Stimulating Hormone

Tena-Sempere M, Pinilla L, Aguilar E. Orchidectomy selectively increases follicle-stimulating hormone secretion in gonadotropin-releasing hormone agonist-treated male rats. Eur J Endocrinol 1995;132: 357–62. ISSN 0804–4643 The pituitary component of the feedback mechanisms exerted by testicular factors on gonadotropin secretion was analyzed in adult male rats treated with a potent gonadotropin-releasing hormone (GnRH) antagonist. In order to discriminate between androgens and testicular peptides, groups of males were orchidectomized (to eliminate androgens and non-androgenic testicular factors) or injected with ethylene dimethane sulfonate (EDS), a selective toxin for Leydig cells (to eliminate selectively androgens) and treated for 15 days with vehicle or the GnRH antagonist Ac-d-pClPhe-d-pClPhe-d-TrpSer-Tyr-d-Arg-Leu-Arg-Pro-d-Ala-NH2CH3COOH (Org.30276, 5 mg/kg/72 hours). Serum concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were measured 7 and 14 days after the beginning of treatment. We found that: in males treated with GnRH antagonist, orchidectomy or EDS treatment did not induce any increase in LH secretion; and orchidectomy, but not EDS treatment, increased FSH secretion in GnRH-treated males. The present results show that negative feedback of testicular factors on LH secretion is mediated completely through changes in GnRH actions. In contrast, a part of the inhibitory action of the testis on FSH secretion is exerted directly at the pituitary level. It can be hypothesized that non-Leydig cell testicular factor(s) inputs at different levels of the hypothalamic–pituitary axis in controlling LH and FSH secretion. Manuel Tena-Sempere, Department of Physiology, Faculty of Medicine, University of Córdoba, 14004 Córdoba, Spain

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