Endoscopic resection of tendon xanthoma in the elbow of a patient with cerebrotendinous xanthomatosis

2021 ◽  
Vol 14 (11) ◽  
pp. e244931
Author(s):  
Katsumasa Nakazawa ◽  
Koichi Yano ◽  
Yasunori Kaneshiro ◽  
Hideki Sakanaka
Keyword(s):  
Treatment Outcomes ◽  
Endoscopic Resection ◽  
Metabolic Disorder ◽  
Cerebrotendinous Xanthomatosis ◽  
Open Resection ◽  
Less Invasive ◽  
Invasive Method ◽  
The Right ◽  
Tendon Xanthoma

We describe the case of a 44-year-old woman with cerebrotendinous xanthomatosis (CTX) who had a tendon xanthoma on the right olecranon. The patient successfully underwent endoscopic resection. There were no signs of recurrence on MRI 2 years postoperatively. There were no complications related to the surgery, and the patient is completely satisfied with the treatment outcomes. CTX, a genetic metabolic disorder, is associated with the development of tendon xanthomas. Endoscopic resection of tendon xanthoma in the elbow of patients with CTX is a less invasive method than open resection.

scholarly journals Sessile serrated adenoma invading a diverticulum in the right colon: tips and tricks for a safe complete endoscopic resection

Endoscopy ◽  
2021 ◽  
Author(s):  
Sophie Geyl ◽  
Jérémie Albouys ◽  
Romain Legros ◽  
Hugo Lepetit ◽  
Martin Dahan ◽  
...  
Keyword(s):  
Endoscopic Resection ◽  
Tips And Tricks ◽  
Right Colon ◽  
Sessile Serrated Adenoma ◽  
Serrated Adenoma ◽  
The Right

scholarly journals Development of Injectable Polydactyly-Derived Chondrocyte Sheets

2021 ◽  
Vol 22 (6) ◽  
pp. 3198
Author(s):  
Shiho Wasai ◽  
Eriko Toyoda ◽  
Takumi Takahashi ◽  
Miki Maehara ◽  
Eri Okada ◽  
...  
Keyword(s):  
Cell Viability ◽  
Cartilage Damage ◽  
Enzyme Linked Immunosorbent Assay ◽  
Invasive Treatment ◽  
Experimental Conditions ◽  
Humoral Factors ◽  
Less Invasive ◽  
Cell Counts ◽  
Invasive Method ◽  
Injection Control

We are conducting a clinical study of the use of allogeneic polydactyly-derived chondrocyte sheets (PD sheets) for the repair of articular cartilage damage caused by osteoarthritis. However, the transplantation of PD sheets requires highly invasive surgery. To establish a less invasive treatment, we are currently developing injectable fragments of PD sheets (PD sheets-mini). Polydactyly-derived chondrocytes were seeded in RepCell™ or conventional temperature-responsive inserts and cultured. Cell counts and viability, histology, enzyme-linked immunosorbent assay (ELISA), quantitative real-time polymerase chain reaction (qPCR), and flow cytometry were used to characterize PD sheets-mini and PD sheets collected from each culture. To examine the effects of injection on cell viability, PD sheets-mini were tested in four experimental conditions: non-injection control, 18 gauge (G) needle, 23G needle, and syringe only. PD sheets-mini produced similar amounts of humoral factors as PD sheets. No histological differences were observed between PD sheets and PD sheets-mini. Except for COL2A1, expression of cartilage-related genes did not differ between the two types of PD sheet. No significant differences were observed between injection conditions. PD sheets-mini have characteristics that resemble PD sheets. The cell viability of PD sheets-mini was not significantly affected by needle gauge size. Intra-articular injection may be a feasible, less invasive method to transplant PD sheets-mini.

Lenticular changes in cerebrotendinous xanthomatosis, a treatable metabolic disorder that is important to recognize

2013 ◽  
Vol 17 (1) ◽  
pp. e18
Author(s):  
Arif O. Khan ◽  
Mohammed A. Aldahmesh ◽  
Arif Jawaher ◽  
Y. Mohamed Fowzan ◽  
S. Alkuraya Khan
Keyword(s):  
Metabolic Disorder ◽  
Cerebrotendinous Xanthomatosis

scholarly journals Abdominal Sacral Colpopexy In Treatment Of Vaginal Vault Prolapse: By Less Invasive Method

2013 ◽  
Vol 25 (1) ◽  
pp. 3-8
Author(s):  
Nahar Nurun ◽  
Molina Rani Kundu ◽  
Naher Akterun
Keyword(s):  
Success Rate ◽  
Vaginal Vault Prolapse ◽  
Vaginal Vault ◽  
Secondary Outcome ◽  
Sacral Colpopexy ◽  
Vault Prolapse ◽  
Abdominal Sacral Colpopexy ◽  
Less Invasive ◽  
Invasive Method ◽  
The Impact

Objective: To assess the outcomes of abdominal sacral colpopexy in less invasive method. Study design: It was a prospective study conducted in Comilla Medical College Hospital and Comilla General Hospital during the period from 2005 to 2009.Method: Thirty women with vaginal vault prolapse were selected by inclusion and exclusion criteria in a consecutive, exhaustive method. Primary outcome measurements were included subjective, objective and patient-determined success rate. Secondary outcome included the impact on bowel, bladder, sexual function and quality of life. Result: Result shows that, vault prolapse is mostly associated with older patients, age more than sixty (66.7%), para >5 (60%) and menopausal women (66.7%). Vault prolapse was mostly associated with cystocele (93.3%), stress incontinence (76.7%) and more common following abdominal hysterectomy (70%). During operation the dissection was less (3-4cm). Average operating time was 54.33/min; average estimated blood loss was 49.17/ml. One patient required blood transfusion, one developed haematoma during surgery, no gut injury or haemodynamic instability developed. Post operatively, no internal haemorrhage, 4 patient developed fever (13.3%), wound infection one (3.3%), UTI 4 patients (13.3%), no voiding difficulty or thromboembolism and one patient developed mesh rejection (3.3%). After one year follow-up success rate was 96.7%. Conclusion: Abdominal sacral colpopexy is a safe and effective method for correction of vaginal vault prolapse. DOI: http://dx.doi.org/10.3329/bjog.v25i1.13723 Bangladesh J Obstet Gynaecol, 2010; Vol. 25(1) : 3-8

scholarly journals Optic Neuropathy with Features Suggestive of Optic Neuritis in Cerebrotendinous Xanthomatosis

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Miyuki Miyamoto ◽  
Nobuyuki Ishii ◽  
Hitoshi Mochizuki ◽  
Kazutaka Shiomi ◽  
Tomoko Kaida ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Optic Neuropathy ◽  
Storage Disease ◽  
Elevated Serum ◽  
Brain Magnetic Resonance Imaging ◽  
Cerebrotendinous Xanthomatosis ◽  
Gadolinium Enhancement ◽  
Lipid Storage Disease ◽  
Optic Disc Swelling ◽  
The Right

We describe our encounter with a 39-year-old man who exhibited acute painless visual loss and progressive gait disturbance. He had tendinous xanthoma and several neuroophthalmological findings indicative of optic neuropathy in the right eye, including afferent pupillary defect, cecocentral scotoma, and optic disc swelling. Neurological examination showed cerebellar ataxia and pyramidal weakness. Brain magnetic resonance imaging revealed bilateral swelling in the optic nerves with gadolinium-enhancement suggesting optic neuritis, an enlarged fourth ventricle, atrophy of the cerebellum, and hyperintensities in the bilateral dentate nuclei. The patient was diagnosed with cerebrotendinous xanthomatosis (CTX) based on an elevated serum cholestanol level and a homozygous missense mutation in CYP27A1. CTX is a genetic lipid storage disease caused by dysfunction of the mitochondrial enzyme sterol 27-hydroxylase. With respect to ophthalmological manifestations, juvenile cataracts and optic neuropathy are common findings in patients with CTX, but there have been no reports of optic neuropathy with features suggestive of optic neuritis. Thus, this case illustrates that clinicians should consider a diagnosis of CTX in patients with cardinal features of CTX even if the patients show signs indicative of optic neuritis.

Recurrent Vertebral Arteriovenous Fistula after Surgical Repair: Treatment with a Self-Expanding Stent-Graft

2003 ◽  
Vol 10 (1) ◽  
pp. 49-53 ◽  
Author(s):  
Ralf Surber ◽  
Gerald S. Werner ◽  
Tina U. Cohnert ◽  
Thorsten Wahlers ◽  
Hans R. Figulla
Keyword(s):  
Vertebral Artery ◽  
Arteriovenous Fistula ◽  
Stent Graft ◽  
Endovascular Repair ◽  
Venous Catheter ◽  
Vertebral Arteriovenous Fistula ◽  
Initial Surgery ◽  
Invasive Method ◽  
Stent Graft Repair ◽  
The Right

Purpose: To describe successful endovascular repair of a recurrent vertebral arteriovenous fistula (AVF) after surgical correction. Case Report: A 42-year-old woman presented with recurrent dizziness, nausea, and headaches. A loud bruit in the right neck was present. Central venous catheter insertion had been done 1 year previously, creating an angiographically documented right-sided vertebral AVF that was successfully excluded by a surgical procedure. Four weeks later, the AVF reappeared. Successful endovascular repair with a self-expanding stent-graft was performed. Follow-up over 12 months was uneventful, with a patent vertebral artery and no recurrence of symptoms. Conclusions: Endovascular stent-graft repair is feasible and offers a therapeutic alternative in the treatment of vertebral AVF, in particular for recurrence after initial surgery. This minimally invasive method may become the treatment of choice in the management of such lesions, preserving patency of the vertebral artery.

scholarly journals P-188 * BILATERAL LUNG VENTILATION DURING LOBECTOMY: A LESS INVASIVE METHOD FOR PATIENTS WITH INTERSTITIAL PNEUMONIA

2014 ◽  
Vol 18 (suppl 1) ◽  
pp. S49-S50
Author(s):  
H. Ishibashi ◽  
R. Wakejima ◽  
A. Asakawa ◽  
K. Seto ◽  
A. Ui ◽  
...  
Keyword(s):  
Interstitial Pneumonia ◽  
Lung Ventilation ◽  
Less Invasive ◽  
Invasive Method ◽  
Bilateral Lung

scholarly journals A Novel Approach Towards Less Invasive Multi ‘Omics Gut Analyses: A Pilot Study

2021 ◽  
Author(s):  
Adam J. Berlinberg ◽  
Ana Brar ◽  
Andrew Stahly ◽  
Mark E. Gerich ◽  
Blair P. Fennimore ◽  
...  
Keyword(s):  
Pilot Study ◽  
Human Microbiome ◽  
Screening Colonoscopy ◽  
Intestinal Biopsy ◽  
Sample Collection ◽  
Less Invasive ◽  
Novel Approach ◽  
Functional Assessments ◽  
Invasive Method ◽  
Cytology Brush

Newer ‘omics approaches such as metatranscriptomics and metabolomics allow functional assessments of the interaction(s) between the gut microbiome and the human host. In order to generate meaningful data with these approaches, though, the method of sample collection is critical. Prior studies have relied upon expensive and invasive means towards sample acquisition such as intestinal biopsy, while other studies have relied upon easier methods of collection such as fecal samples that do not necessarily represent those microbes in contact with the host. In this pilot study, we attempt to characterize a novel, minimally invasive method towards sampling the human microbiome using mucosal cytology brush sampling compared to intestinal gut biopsy on 5 healthy participants undergoing routine screening colonoscopy. We compared metatranscriptomic analyses between the two collection methods, identifying increased taxonomic evenness and beta diversity in the cytology brush samples, and similar community transcriptional profiles between the two methods. Metabolomics assessment demonstrated striking differences between the two methods, implying a difference in bacterial-derived versus human absorbed metabolites. Put together, this study supports the use of a less invasive method of microbiome sampling with cytology brushes, but caution must be exercised when performing metabolomics assessment as this represents differential metabolite production but not absorption by the host.

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