scholarly journals Normative data and percentile curves for axial length and axial length/corneal curvature in Chinese children and adolescents aged 4–18 years

2021 ◽  
pp. bjophthalmol-2021-319431
Author(s):  
Xiangui He ◽  
Padmaja Sankaridurg ◽  
Thomas Naduvilath ◽  
Jingjing Wang ◽  
Shuyu Xiong ◽  
...  
Keyword(s):  
Axial Length ◽  
Intraclass Correlation ◽  
Radius Of Curvature ◽  
Specific Reference ◽  
Model Risk ◽  
Percentile Curves ◽  
Corneal Radius ◽  
And Gender ◽  
Gender Specific ◽  
Chinese Children And Adolescents

PurposeTo develop age-specific and gender-specific reference percentile charts for axial length (AL) and AL/corneal radius of curvature (AL/CR) and, to use percentiles to determine probability of myopia and estimate refractive error (RE).MethodsAnalysis of AL, cycloplegic RE and CR of 14 127 Chinese participants aged 4–18 years from 3 studies. AL and AL/CR percentiles estimated using Lambda-Mu-Sigma method and compared for agreement using intraclass correlation (ICC). Logistic regression was used to model risk of myopia based on age, gender, AL and AL/CR percentiles. Accuracy of AL progression and RE estimated using percentiles was validated using an independent sample of 5742 eyes of children aged 7–10 years.ResultsAge-specific and gender-specific AL and AL/CR (3rd, 5th, 10th, 25th, 50th, 75th, 90th and 95th) percentiles are presented. Concordance between AL and AL/CR percentiles improved with age (0.13 at 4 years to >0.75 from 13 years) and a year-to-year change was observed for all except <10th percentile from 15 years. Increasing age, AL and AL/CR was associated with a more myopic RE (r2=0.45,0.70 and 0.83, respectively). The sensitivity and specificity of the model to estimate probability of myopia was 86.0% and 84.5%, respectively. Estimation of 1-year change in AL using percentiles correlated highly with actual AL (ICC=0.98). Concordance of estimated to actual RE was high (ICC=0.80) and within ±0.50D and ±1.0D of actual RE for 47.4% and 78.9% of eyes, respectively.ConclusionAge-specific and gender-specific AL and AL/CR percentiles provide reference data, aid in identifying and monitoring individuals at risk of myopia and have utility in screening for myopia. AL/CR percentiles were more accurate in estimating probability of myopia in younger children.

scholarly journals Age-specific and sex-specific reference intervals for non-fasting lipids and apolipoproteins in 7260 healthy Chinese children and adolescents measured with an Olympus AU5400 analyser: a cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e030201
Author(s):  
Junjie Liu ◽  
Yanpeng Dai ◽  
Enwu Yuan ◽  
Yushan Li ◽  
Quanxian Wang ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Density Lipoprotein ◽  
Reference Intervals ◽  
Chinese Children ◽  
Lipoprotein Cholesterol ◽  
Specific Reference ◽  
Healthy Chinese ◽  
And Gender ◽  
Gender Specific ◽  
Chinese Children And Adolescents

AimsEthnic, demographic, lifestyle, genetic and environmental factors influence lipids and apolipoproteins. The aim of this study was to establish age-specific and gender-specific reference intervals for non-fasting lipids and apolipoproteins in healthy Chinese children and adolescents.MethodsThis study followed the Clinical and Laboratory Standards Institute EP28-A3c guidelines. Non-fasting samples were collected from 7260 healthy Chinese children and adolescents, and they were analysed using the Olympus AU5400 analyser for: triglycerides, total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 and apolipoprotein B (ApoB). The age-related and gender-related reference intervals were partitioned using the Harris-Boyd method. The non-parametric method was used to establish the lower limit (2.5th percentile) and the upper limit (97.5th percentile) for the reference intervals. The 90% CIs for the lower and upper limits were also calculated.ResultsBased on the Harris-Boyd method, gender partitions were required for TC, LDL-C and ApoB. Age differences were observed for all analytes. Paediatric reference intervals were established for non-fasting lipids and apolipoproteins based on a large population of healthy children and adolescents.ConclusionsPreviously used reference intervals did not take age and gender into account. These age-specific and gender-specific reference intervals established in this study may contribute to improved management and assessment of paediatric diseases.

scholarly journals The Correlation of Cycloplegic Refraction with Corneal Radius of Curvature-Adjusted Axial Length in Chinese Preschoolers

2021 ◽  
Author(s):  
Xiao-hong Zhou ◽  
Yian Li ◽  
Wei Wang ◽  
Chen-hao Yang
Keyword(s):  
Axial Length ◽  
Chinese Children ◽  
Radius Of Curvature ◽  
Refractive Errors ◽  
Spherical Equivalent ◽  
Spherical Equivalent Refraction ◽  
Curvature Coefficient ◽  
Corneal Radius ◽  
The Mean ◽  
And Gender

Abstract Background: In order to master the refractive status and detect severe refractive errors quickly and effectively, this study aimed to investigate the association of axial length after adjusting for corneal radius of curvature with refraction in a group of Chinese preschoolers. Methods: Retrospective review of 716 Chinese children aged from 3 to 6 years, who underwent cycloplegic optometry with 1% atropine eye gel in the ophthalmology department of Children’s Hospital of Fudan University, National Children’s Medical Center in Shanghai. Meanwhile axial length, corneal radius of curvature and cycloplegic autorefraction were obtained and axial length/corneal radius of curvature (AL/CR) ratio was calculated. The correlations of spherical equivalent refraction (SER) with axial length, corneal radius of curvature, AL/CR ratio and corneal radius of curvature-adjusted axial length were analyzed. Results: Only data from the right eye were included in this analysis. Among 716 eyes of 716 Chinese preschoolers, the mean (±SD) SER was 2.28±2.41 diopters (D), of which hyperopia, emmetropia, myopia were 84.64%, 8.54%, 6.84%, respectively. The mean(±SD) axial length, corneal radius of curvature and AL/CR ratio were 21.89±1.01mm, 7.76±0.27 mm, and 2.82±0.13, respectively. The SER was highly negative correlated with both axial length (coefficient –0.722) and AL/CR ratio (coefficient-0.814), and weakly correlated with corneal radius of curvature (coefficient 0.090) and gender(coefficient 0.093). Axial length was weakly correlated with age and gender(coefficient 0.232 and 0.268, respectively), but moderately correlated with corneal radius of curvature (coefficient 0.424). After adjusting for corneal radius of curvature, the correlation coefficient between SER and axial length significantly increased to-0.918. Conclusion: In the samples of 716 3-to 6-year-old Chinese children, axial length was moderately correlated with corneal radius of curvature. After adjusting for corneal radius of curvature, refraction was closely correlated with axial length than axial length alone and AL/CR ratio. Therefore, corneal radius of curvature-adjusted axial length might be a useful tool for pediatric ophthalmologists to detect refractive errors. Key Words: spherical equivalent refraction; corneal radius of curvature; adjusted; axial length; preschoolers.

Developing waist circumference, waist-to-height ratio percentile curves for Pakistani children and adolescents aged 2–18 years using Lambda-Mu-Sigma (LMS) method

2020 ◽  
Vol 33 (8) ◽  
pp. 983-993 ◽  
Author(s):  
Muhammad Asif ◽  
Muhammad Aslam ◽  
Saima Altaf ◽  
Sajid Mustafa
Keyword(s):  
Waist Circumference ◽  
Central Obesity ◽  
The Other ◽  
Height Ratio ◽  
Age And Gender ◽  
Percentile Curves ◽  
Lms Method ◽  
Waist To Height Ratio ◽  
And Gender ◽  
Gender Specific

AbstractObjectivesChildren from different countries and with different ethnic backgrounds have a distinct pattern of central fat deposition. Therefore, it is essential to develop population-specific percentiles of waist circumference (WC), waist-to-height ratio (WHtR) and waist-to-height ratio exponent (WHtR (exp)) for the evaluation of central obesity. The objective of this study was to develop age-and-gender-specific smoothed WC and WHtR percentile curves for the Pakistani children and adolescents aged 2–18 years.MethodsA cross-sectional data-set from a multi-ethnic anthropometric survey was considered. A sample of 10,668 healthy subjects (boys = 51.92%; and girls = 48.08%), aged 2–18 years was studied. Height (cm) and WC (cm) of each subject was measured under standard procedure and WHtR & WHtR (exp) were calculated. Age-and-gender-specific smoothed curves were obtained using the lambda-mu-sigma (LMS) method and compared with percentile curves obtained from different countries.ResultsExcept few early ages, the WC values increased with age in both sexes. Both boys and girls had approximately similar WC during 6–11 years of age and after age of 11, the boys had larger WC than the girls had. For WHtR, the centile curves showed a continuous decrease by 16 years of age and then increased gradually. WHtR of the girls in various ages were having similar or higher than those of the boys. In comparison of WC 50th and 90th percentiles with other countries, it was found that except few ages, the Pakistani children had larger WC than the other reference populations and the results of WHtR were also comparable to the other nations.ConclusionsWe present new reference data of WC, WHtR and WHtR (exp) using a representative sample of the Pakistani children aged 2–18 years. These reference values can be used provisionally for early detection of central obesity and its associated risks in the Pakistani children.

Reference intervals of spinal mobility measures in normal individuals: the mobility study

2014 ◽  
Vol 74 (6) ◽  
pp. 1218-1224 ◽  
Author(s):  
Sofia Ramiro ◽  
Astrid van Tubergen ◽  
Carmen Stolwijk ◽  
Désirée van der Heijde ◽  
Patrick Royston ◽  
...  
Keyword(s):  
Axial Spondyloarthritis ◽  
Cross Sectional Study ◽  
Reference Intervals ◽  
Spinal Mobility ◽  
Cross Sectional ◽  
Percentile Curves ◽  
Normal Individuals ◽  
And Gender ◽  
Gender Specific ◽  
Spinal Flexion

ObjectivesTo establish reference intervals (RIs) for spinal mobility measures as recommended for patients with axial spondyloarthritis, and to determine the effect of age, height and gender on spinal mobility, in normal individuals.MethodsA cross-sectional study (MOBILITY) was conducted among normal individuals aged 20–69 years. Recruitment was stratified by gender, age (10-year categories) and height (10 cm categories). Eleven spinal mobility measures were assessed. Age specific RIs and percentiles were derived for each measure.Results393 volunteers were included. All spinal mobility measures decreased with increasing age. Therefore, age specific RIs were developed. The 95% RIs (2.5th and 97.5th percentiles), as well as the 5th, 10th, 25th, 50th, 75th and 90th percentiles for each spinal mobility measure and different ages are presented. Mobility percentile curves were also plotted for each of the measures. For instance, the 95% RI for lateral spinal flexion was 16.2–28.0 cm for a 25-year-old subject, 13.2–25.0 cm for a 45-year-old subject and 10.1–21.9 cm for a 65-year-old subject. After adjustment for age, there was no need for gender specific RIs, while RIs of some measures are height-adjusted.ConclusionsAge specific RIs and percentiles were derived for each of the spinal mobility measures for normal individuals. These may guide clinicians when assessing the mobility of patients with axial spondyloarthritis. The RIs may serve as cut-off levels for ‘normal’ versus ‘abnormal’, whereas the mobility percentile curves may be used to assess the level of mobility of patients with axial spondyloarthritis.

FOUR-SITE SKINFOLDS THICKNESS PERCENTILES of SCHOOLCHILDREN and ADOLESCENTS in TURKEY

2021 ◽  
pp. 1-28
Author(s):  
Meltem Soylu ◽  
Nazlı Şensoy ◽  
İsmet Doğan ◽  
Nurhan Doğan ◽  
Mümtaz M. Mazicioğlu ◽  
...  
Keyword(s):  
Body Fat ◽  
Skinfold Thickness ◽  
Population Based ◽  
Specific Reference ◽  
Fat Percentage ◽  
Cross Sectional ◽  
Lms Method ◽  
And Gender ◽  
Thickness Measurements ◽  
Gender Specific

Abstract Objective: The primary purpose of this study was to establish Turkish smoothed centile charts and LMS tables for four-site skinfold thickness based on a population-based sample and secondary purpose was to elaborate a reference for the percentage of body fat. Design: A cross-sectional and descriptive study was conducted between January and May 2017. Triceps, biceps and subscapular, suprailiac skinfold thickness were measured using Holtain skinfold caliper. Age and gender specific percentile values were determined with the LMS method, and body fat percentage was calculated using the Westrate and Deurenberg equation. Setting: Afyonkarahisar province in Turkey. Participants: This study was conducted on 4565, 6-18 years old students. Results: The triceps, biceps, and subscapular skinfolds of the girls were higher than the boys. From the age of seven, the sum of four skinfold thicknesses of the girls was more than those of the boys. This difference became more evident after the age of 12. Although fat percentages of girls showed a fluctuating change, it decreased with the age in boys. Westrate and Deurenberg equation fat percentages of girls until adolescence were lower than boys, but increased after 12 years of age and exceeded that of boys. Conclusions: This study has provided sex and age specific reference values for skinfold thickness, and has shown that obesity in girls is higher than in boys in schoolchildren in Afyonkarahisar. This study has also shown that skinfold thickness measurements are a valuable tool for screening obesity in children.

scholarly journals The Role of Axial Length-Corneal Radius of Curvature Ratio in Refractive State Categorization in a Nigerian Population

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Eghosasere Iyamu ◽  
Joy Iyamu ◽  
Christian Izuchukwu Obiakor
Keyword(s):  
Axial Length ◽  
Inverse Correlation ◽  
Radius Of Curvature ◽  
Spherical Equivalent ◽  
Refractive State ◽  
Spherical Equivalent Refraction ◽  
Nigerian Population ◽  
Corneal Radius ◽  
The Mean

The aim of this study was to investigate the association of axial length (AL)/corneal radius of curvature (CRC) ratio (AL/CRC) with spherical equivalent refractive state (SER) in young adults. A total of seventy () subjects consisting of 31 males and 39 females participated in this study. Subjects were categorized into emmetropia, hyperopia and myopia using the spherical equivalent refraction. The axial length was measured with I-2100 A-Scan ultrasonography/Biometer (CIMA Technology, USA), the corneal radius of curvature with Bausch & Lomb H-135A (Bausch & Lomb Corp., USA), and the refractive state by static retinoscopy and subjective refraction. The mean AL, CRC and AL/CRC ratio of all subjects were 23.74 ± 0.70 mm, 7.84 ± 0.19 mm, and 3.03 ± 0.14, respectively. Myopes had significantly longer AL, steeper CRC and higher AL/CRC ratio than the emmetropes and hyperopes. There was statistically significant inverse correlation between AL and CRC (, ), SER (, ), and between SER and AL/CRC (, ). A significant positive correlation was found between CRC and SER (, ). The categorization of the refractive state of an individual is better done by using the AL/CRC ratio index.

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