ASSESSMENT OF IN VIVO LOADING HISTORY OF THE PATELLOFEMORAL JOINT- A STUDY COMBINING PATELLAR POSITION, TILT, ALIGNMENT AND BONE SPECT/CT TRACER UPTAKE/DISTRIBUTION PATTERNS

Background: SPECT/CT distribution patterns in patients with total knee replacements have previously been correlated with factors such as time of implantation, implant type and alignment. It is unknown, however, if an increased and more extended bone tracer uptake (BTU) in SPECT/CT, representing loading of the joint, correlates with findings from retrieval studies. The aim of this study was to further understand this subject. Materials and Methods: 62 retrieved TKA were included. SPECT/CT was performed prior to revision. Quantitative and qualitative medio-lateral comparisons of BTU intensity and distribution in the tibia were performed. Retrieval analysis was performed with a micro-CT method to assess the thickness differences between medial and lateral sides of polyethylene inserts with symmetrical designs. Results: In the subgroup of TKA with asymmetrical SPECT/CT distribution, there was a significant correlation between retrieval and medical imaging data (p = 0.0355): patients showing a more extended BTU in the medial compartment also had a significantly thinner insert in the medial compartment, and vice versa in the lateral side. Conclusion: This is the first study comparing BTU distribution patterns and retrieval findings. Our results support the hypothesis that SPECT/CT is able to identify bone activity due to implant position and loading.

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The in vivo mechanical loading history of bone

Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. No.99CH37015) ◽

10.1109/iembs.1999.802579 ◽

2003 ◽

Author(s):

S.P. Fitton

Keyword(s):

Mechanical Loading ◽

Loading History ◽

History Of

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Absolute SPECT/CT quantification of cerebral uptake of 99mTc-HMPAO for patients with neurocognitive disorders

Nuklearmedizin ◽

10.3413/nukmed-0765-15-09 ◽

2016 ◽

Vol 55 (04) ◽

pp. 158-165 ◽

Cited By ~ 3

Author(s):

Friedrich Welz ◽

James Sanders ◽

Torsten Kuwert ◽

Juan Maler ◽

Johannes Kornhuber ◽

...

Keyword(s):

Tissue Concentration ◽

Tracer Uptake ◽

Planar Imaging ◽

Quantitative Spect ◽

Dementia Patients ◽

Hmpao Spect ◽

Patient Groups ◽

The Absolute ◽

99Mtc Hmpao

SummaryIt was reported from planar imaging studies that the cerebral uptake of injected 99mTc-HMPAO activity is about 4–7% in humans. Recent work has shown that modern SPECT/ CT devices are able to quantify the tissue concentration of radioactivity in vivo in absolute units (Bq/ml), while avoiding the limitations of planar techniques. The aims of this study were (a) to determine the cerebral uptake of 99mTc-HMPAO in absolute units in SPECT/CT, (b) to investigate potential differences in absolute tracer uptake for patients suspected of dementia. Patients, methods: We performed 99mTc-HMPAO SPECT/CT in 65 patients with suspected dementia. 99mTc-HMPAO uptake was determined using a previously published quantitative SPECT/CT protocol. The absolute HMPAO uptake and the results of a regionalized analysis were compared for MMSE and NINCDS-ADRDA based patient groups. Results: The mean absolute uptake of 99mTc-HMPAO for our patient population was 4.3 ± 0.8% of the injected dose. The uptake, as well as the regionalized analysis yielded significantly different results for low ( 23) and high (>23) MMSE groups and also for some of the NINCDS-ADRDA groups. Conclusion: Our results show that the absolute cerebral uptake of 99mTc-HMPAO is in the range of previously reported results, obtained by planar techniques. Absolute uptake is significantly different between the patient groups.

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Biological NMR Spectroscopy

10.1093/oso/9780195094688.001.0001 ◽

1997 ◽

Keyword(s):

Nuclear Magnetic Resonance ◽

Nmr Spectroscopy ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

State Of The Art ◽

Critical Assessment ◽

Resonance Spectroscopy ◽

History Of ◽

Structure Of Proteins

This book presents a critical assessment of progress on the use of nuclear magnetic resonance spectroscopy to determine the structure of proteins, including brief reviews of the history of the field along with coverage of current clinical and in vivo applications. The book, in honor of Oleg Jardetsky, one of the pioneers of the field, is edited by two of the most highly respected investigators using NMR, and features contributions by most of the leading workers in the field. It will be valued as a landmark publication that presents the state-of-the-art perspectives regarding one of today's most important technologies.

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A Useful Diagnostic Method for Drug-induced Pneumonitis

The American Journal of Chinese Medicine ◽

10.1142/s0192415x94000395 ◽

1994 ◽

Vol 22 (03n04) ◽

pp. 329-336 ◽

Cited By ~ 19

Author(s):

Akira Kawasaki ◽

Yutaka Mizushima ◽

Hitoshi Kunitani ◽

Masanobu Kitagawa ◽

Masashi Kobayashi

Keyword(s):

Bronchoalveolar Lavage Fluid ◽

Challenge Test ◽

Lavage Fluid ◽

Peripheral Blood Lymphocytes ◽

Lymphocyte Stimulation Test ◽

Drug Induced ◽

Chief Complaints ◽

History Of ◽

Chest X Ray

A 51 year-old male was admitted to our hospital with chief complaints of fever, dry cough and dyspnea. Chest X -ray films and his history of taking Chinese medicine for liver dysfunction were suggestive of drug-induced pneumonitis. Lymphocyte stimulation test (LST) to causative Chinese medical drugs of Sho-saiko-to and Dai-saiko-to was negative with peripheral blood lymphocytes (PBL), but was positive with Iymphocytes from bronchoalveolar lavage fluid (BALF). In vivo challenge test for Sho-saiko-to was positive. The LST with BALF-lymphocytes proved to be very useful in making a diagnosis of drug-induced pneumonitis.

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The loading history of trace metals and nutrients in Altata-Ensenada del Pabellón, lagoon complex, northwestern Mexico

Journal of Environmental Radioactivity ◽

10.1016/s0265-931x(03)00091-2 ◽

2003 ◽

Vol 69 (1-2) ◽

pp. 129-143 ◽

Cited By ~ 7

Author(s):

A.C. Ruiz-Fernández ◽

F. Páez-Osuna ◽

M. Soto-Jiménez ◽

C. Hillaire-Marcel ◽

B. Ghaleb

Keyword(s):

Trace Metals ◽

Loading History ◽

History Of ◽

Northwestern Mexico

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Validation of an MRI-based method to assess patellofemoral joint contact areas in loaded knee flexion in vivo

Journal of Magnetic Resonance Imaging ◽

10.1002/jmri.24240 ◽

2013 ◽

Vol 39 (4) ◽

pp. 978-987 ◽

Cited By ~ 4

Author(s):

Emily J. McWalter ◽

Colm M. O'Kane ◽

David P. FitzPatrick ◽

David R. Wilson

Keyword(s):

Knee Flexion ◽

Patellofemoral Joint ◽

Contact Areas ◽

Joint Contact

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Severe Hemolytic Reaction Due to Anti-JK3

Archives of Pathology & Laboratory Medicine ◽

10.5858/1999-123-0949-shrdta ◽

1999 ◽

Vol 123 (10) ◽

pp. 949-951

Author(s):

Carol S. Marshall ◽

Denis Dwyre ◽

Robin Eckert ◽

Liisa Russell

Keyword(s):

The United States ◽

Cell Phenotype ◽

Prior History ◽

Ethnic Variability ◽

Hemolytic Transfusion Reaction ◽

History Of ◽

Rare Phenotype ◽

Antibody Screen

Abstract A 35-year-old gravida 3, para 3 Filipino woman with a negative antibody screen, no prior history of transfusion, and no hemolytic disease of the newborn in her children suffered a massive postpartum hemorrhage requiring transfusion. A severe hemolytic transfusion reaction occurred 5 days after delivery. Subsequently, a panagglutinin on a routine antibody identification panel was identified as anti-Jk3. The patient's red blood cell phenotype was Jk(a−b−) and all of her children were Jk(a−b+), yet the antibody that formed reacted with equal strength against all Jka- or Jkb-positive cells. The rare Jk(a−b−) phenotype is more common in Polynesians. Anti-Jk3, like other Kidd system antibodies, is difficult to detect because in vivo production may be absent between provocative episodes and because these antibodies often show weak in vitro reactions. The increasing numbers of Pacific Islanders in the United States could result in more frequent encounters with this rare phenotype. Increased awareness of ethnic variability in blood phenotypes and of the capricious nature of Kidd antibodies can help pathologists and technologists deal more effectively with these cases.

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