Serum levels of doxycycline in normal subjects after a single oral dose.

ABSTRACT:Growth hormone (GH) serum levels in response to the administration of aminergic drugs and thyroliberine (TRH) were determined in a group of 34 acromegalics. Administration of bromocriptine (10 mg single oral dose) was followed by a decrease in GH below 60% control values in 35% of the cases. Administration of diazepam (10 mg single oral dose) to those cases not responding to bromocriptine induced a decrease in GH in 58% of the cases and an increase in GH in 42%. Administration of cyproheptadine (24 mg/day for one month) to those cases not responding to bromocriptine or with increased GH after the administration of diazepam, decreased GH in 75%, while increased GH in 25% of the cases. TRH 200 (Xg single I.V. dose induced increase of 128% GH basal level in 65% of cases (TRH positive) which correlated with more benign clinical course, decreased GH levels in response to bromocriptine, increased PRL levels, PRL-GH mixed secreting adenomas in immunohistochemistry studies, presence of granulated cells in electron microscopy studies and normalization of GH in the majority of surgically treated cases. By contrast, TRH negative cells correlated with aggressive tumor growth, lack of response to bromocriptine, normal PRL levels, pure GH secreting adenomas by immunohistochemistry, poorly granulated cells and lack of response to surgical treatment. Results suggest that there is more than one type of acromegaly that might be distinguished by the aminergic control on GH secretion.

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Preprandial Single Oral Dose of Sitagliptin Does Not Affect Circulating Ghrelin and Gastrin Levels in Normal Subjects

Pharmacology ◽

10.1159/000280583 ◽

2010 ◽

Vol 85 (3) ◽

pp. 131-135 ◽

Cited By ~ 9

Author(s):

Chen-Ling Huang ◽

Chung-Huei Hsu ◽

Kuo-Cherh Huang ◽

Hsiu-Yueh Su ◽

Shuen-Fu Weng

Keyword(s):

Oral Dose ◽

Single Oral Dose ◽

Normal Subjects

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A single dose of lithium carbonate acutely elevates intact parathyroid hormone levels in humans

Acta Endocrinologica ◽

10.1530/acta.0.1210174 ◽

1989 ◽

Vol 121 (2) ◽

pp. 174-176 ◽

Cited By ~ 31

Author(s):

Ellen W. Seely ◽

Thomas J. Moore ◽

Meryl S. LeBoff ◽

Edward M. Brown

Keyword(s):

Oral Dose ◽

Single Oral Dose ◽

Human Subjects ◽

Lithium Carbonate ◽

Serum Levels ◽

Ionized Calcium ◽

Intact Parathyroid Hormone ◽

Intact Pth

Abstract. Hyperparathyroidism has been reported in patients receiving lithium therapy, and lithium alters calcium-regulated PTH release in vitro. Previous studies in vivo have used assays which measure fragments of PTH as well as the intact hormone. To determine if lithium acutely elevates intact PTH levels, we studied 9 subjects who received a single oral dose of lithium carbonate (600 mg). Serum levels of intact PTH, ionized calcium, and lithium were measured before, 2 and 14 h after the dose of lithium. PTH levels rose significantly 2 h following the dose of lithium (before 22 ± 5.0, post 32 ± 7.3 ng/l, p < 0.02). PTH levels had returned to baseline at 14 h (22 ± 3.8 ng/l). There were no significant changes in ionized calcium levels. Therefore, a single oral dose of lithium carbonate acutely elevates intact PTH values in human subjects.

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Bile and serum levels of tinidazole after a single oral dose.

British Journal of Clinical Pharmacology ◽

10.1111/j.1365-2125.1982.tb01363.x ◽

1982 ◽

Vol 13 (2) ◽

pp. 233-234 ◽

Cited By ~ 7

Author(s):

PS Hunt ◽

AJ Davidson ◽

J Alden ◽

S Cheng

Keyword(s):

Oral Dose ◽

Single Oral Dose ◽

Serum Levels

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A Rapid (48 hours) Thyroid Suppression Test using a Single Oral Dose of 100 of Triiodothyronine

Nuklearmedizin ◽

10.1055/s-0038-1624823 ◽

1973 ◽

Vol 12 (03) ◽

pp. 218-224

Author(s):

Elli Lakka - Papadodima ◽

Constantin Ntalles ◽

Denis Ikkos

Keyword(s):

Oral Dose ◽

Single Oral Dose ◽

Suppression Test

Des mesurages répétés de la fixation thyroïdienne de 10 minutes du 132I injecté intraveineusement on été effectués sur 55 malades euthyroïdiens sans et avec goitre et sur 16 malades hyperthyreoïdiens par 4 jours consécutifs. Immédiatement après le premier mesurage tous les malades recevaient une dose unique oral de 100 μg de Triiodothyronine (T3). Les valeurs de fixation 24, 48 et 72 heures après le T3 (moyen ± déviation standard) étaient de 75 ± 1,7, 64 ± 1,8, et 67 ± 1,9 dans le groupe euthyroïdien et le 106 ± 2,6, 104 ± 2,2 et 108 ± 4,0 dans le groupe hyperthyroïdien, exprimés en pourcentage du groupe controle. 48 heures après T3 tous les personnes euthyroïdiens, sauf une, avaient des valeurs en dessous de 88% tandis que la valeur la plus basse des personnes hyperthyroïdiens ce jour était de 93%. La séparation des valeurs 48 heures des deux groupes était complète après avoir respecté l’influence de la première fixation sur la valeur 48 heures. On peut donc supposer q’un test thyroïdien de suppression utilisable en clinique peut-être effectué en 48 heures après une administration oral de 100 μg de T3 et mesurage de la fixation 10 minutes après l’injection du radioisotope.

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Effect of Aspirin on the Thrombelastogram of Human Blood

Thrombosis and Haemostasis ◽

10.1055/s-0038-1649127 ◽

1973 ◽

Vol 30 (03) ◽

pp. 494-498 ◽

Cited By ~ 1

Author(s):

G de Gaetano ◽

J Vermylen

Keyword(s):

Oral Dose ◽

Single Oral Dose ◽

Platelet Function ◽

Human Blood ◽

Platelet Rich Plasma ◽

Plasma Samples ◽

Release Reaction ◽

Platelet Release

SummaryThrombelastograms of both native blood and re-calcified platelet-rich plasma samples taken from subjects given a single oral dose of aspirin (1 gram) were not significantly different from the pretreatment recordings. Aspirin also did not modify the thrombelastogram when preincubated in vitro with platelet-rich plasma at concentrations inhibiting the platelet “release reaction” by collagen. Thrombelastography therefore cannot evaluate the effect of aspirin on platelet function.

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Serum Enzyme, Corticosterone and Tissue Changes in Rats Following a Single Oral Dose of Ethanol

Quarterly Journal of Studies on Alcohol ◽

10.15288/qjsa.1970.31.281 ◽

1970 ◽

Vol 31 (2) ◽

pp. 281-287 ◽

Cited By ~ 2

Author(s):

Paul D. Altland ◽

Benjamin Highman ◽

Milton G. Parker ◽

Michael P. Dieter

Keyword(s):

Oral Dose ◽

Single Oral Dose ◽

Serum Enzyme ◽

Tissue Changes

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Effects of a single oral dose of phenobarbital on prolactin, growth hormone and luteinizing hormone in normal women

Acta Endocrinologica ◽

10.1530/acta.0.1030309 ◽

1983 ◽

Vol 103 (3) ◽

pp. 309-314 ◽

Cited By ~ 8

Author(s):

G. Rosadini ◽

P. Masturzo ◽

G. Rodriguez ◽

G. Murialdo ◽

V. Montano ◽

...

Keyword(s):

Growth Hormone ◽

Luteinizing Hormone ◽

Oral Dose ◽

Single Oral Dose ◽

Power Analysis ◽

Sleep Pattern ◽

Absolute Power ◽

Normal Women

Abstract. The effects of a single oral dose of phenobarbital (PB) on the 24 h secretion of prolactin, growth hormone and luteinizing hormone have been evaluated in normal women. An EEG record was taken and barbiturate levels assayed in serum. A statistically significant decrease of growth hormone 24 h mean levels was observed and growth hormone and prolactin values during sleep were diminished. No changes in luteinizing hormone concentrations were observed. After PB the EEG showed no important alterations in sleep pattern, but on the power analysis an increase above 16 Hz absolute power was detected during the waking period.

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