scholarly journals Differential Response to Aminergic Stimuli and Biological Behavior of Growth Hormone Secreting Pituitary Adenomas

1990 ◽  
Vol 17 (1) ◽  
pp. 78-82 ◽  
Author(s):  
Guillermo Fanghanel ◽  
Oscar Larraza ◽  
Martha Villalobos ◽  
Leticia Fanghanel ◽  
Marcos Velasco ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Growth Hormone ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Clinical Course ◽  
Serum Levels ◽  
Biological Behavior ◽  
Treatment Results ◽  
Gh Secretion ◽  
Aggressive Tumor

ABSTRACT:Growth hormone (GH) serum levels in response to the administration of aminergic drugs and thyroliberine (TRH) were determined in a group of 34 acromegalics. Administration of bromocriptine (10 mg single oral dose) was followed by a decrease in GH below 60% control values in 35% of the cases. Administration of diazepam (10 mg single oral dose) to those cases not responding to bromocriptine induced a decrease in GH in 58% of the cases and an increase in GH in 42%. Administration of cyproheptadine (24 mg/day for one month) to those cases not responding to bromocriptine or with increased GH after the administration of diazepam, decreased GH in 75%, while increased GH in 25% of the cases. TRH 200 (Xg single I.V. dose induced increase of 128% GH basal level in 65% of cases (TRH positive) which correlated with more benign clinical course, decreased GH levels in response to bromocriptine, increased PRL levels, PRL-GH mixed secreting adenomas in immunohistochemistry studies, presence of granulated cells in electron microscopy studies and normalization of GH in the majority of surgically treated cases. By contrast, TRH negative cells correlated with aggressive tumor growth, lack of response to bromocriptine, normal PRL levels, pure GH secreting adenomas by immunohistochemistry, poorly granulated cells and lack of response to surgical treatment. Results suggest that there is more than one type of acromegaly that might be distinguished by the aminergic control on GH secretion.

Effects of a single oral dose of phenobarbital on prolactin, growth hormone and luteinizing hormone in normal women

1983 ◽  
Vol 103 (3) ◽  
pp. 309-314 ◽  
Author(s):  
G. Rosadini ◽  
P. Masturzo ◽  
G. Rodriguez ◽  
G. Murialdo ◽  
V. Montano ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Luteinizing Hormone ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Power Analysis ◽  
Sleep Pattern ◽  
Absolute Power ◽  
Normal Women

Abstract. The effects of a single oral dose of phenobarbital (PB) on the 24 h secretion of prolactin, growth hormone and luteinizing hormone have been evaluated in normal women. An EEG record was taken and barbiturate levels assayed in serum. A statistically significant decrease of growth hormone 24 h mean levels was observed and growth hormone and prolactin values during sleep were diminished. No changes in luteinizing hormone concentrations were observed. After PB the EEG showed no important alterations in sleep pattern, but on the power analysis an increase above 16 Hz absolute power was detected during the waking period.

Disturbances of growth hormone-insulin-like growth factor axis and response to growth hormone in acidosis

1998 ◽  
Vol 275 (1) ◽  
pp. R120-R128
Author(s):  
Karina Jandziszak ◽  
Carlos Suarez ◽  
Ethan Wasserman ◽  
Ross Clark ◽  
Bonnie Baker ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Food Intake ◽  
Linear Growth ◽  
Growth Failure ◽  
Serum Levels ◽  
Igf Binding Proteins ◽  
Gh Secretion ◽  
Term Administration ◽  
Igf Binding ◽  
Final Length

Severe chronic metabolic acidosis (CMA) in rats is associated with poor food intake and downregulation of growth hormone (GH), insulin-like growth factors (IGFs), and liver receptors; the administration of recombinant GH (rGH) fails to improve the growth failure. In mice with carbonic anhydrase II deficiency (CAD), a model of moderate CMA with food intake close to normal, we studied serum levels of GH, IGFs, and IGF-binding proteins, and the growth response to rGH. CAD was associated with low serum levels of GH in males. Randomized administration of rGH from ∼5 to ∼12 wk to CAD mice improved food efficiency and increased serum IGF-I levels, final length, and weight compared with placebo without affecting blood pH. Although administration of rGH also increased linear growth in healthy animals, the effect was less than that in CAD mice and was only observed when started before 6 wk of life. Thus growth failure in CAD mice is associated with a decrease in GH secretion in males but not in females. Long-term administration of rGH increases linear growth in CAD mice despite persistent CMA.

Serum levels of growth hormone during the stunted postnatal development of the vasopressin-deficient Brattleboro rat

1983 ◽  
Vol 98 (3) ◽  
pp. 351-356 ◽  
Author(s):  
G. J. Boer ◽  
M. Rieutort
Keyword(s):  
Growth Hormone ◽  
Postnatal Development ◽  
Serum Levels ◽  
Postnatal Growth ◽  
The Body ◽  
Rapid Decline ◽  
Brattleboro Rats ◽  
Brattleboro Rat ◽  
Gh Secretion ◽  
Constant Period

Levels of GH in serum were assayed during the development of heterozygous (HET) control and vasopressin-deficient homozygous (HOM) Brattleboro rats. In early postnatal growth no differences in GH concentrations were present between HET and HOM rats for the rapid decline in serum levels of GH in the first week and the constant period up to day 24 of age thereafter. However, higher values were found in 55-day-old HOM rats and lower values at the age of 9 months. It is concluded that the stunted development of the body and brain of HOM rats is not GH-related, and that changes or anomalies in GH secretion appear only after neurogenesis has been completed.

Effect of Sodium Valproate on The Secretion of Prolactin, Cortisol and Growth Hormone in Migraine Patients

Cephalalgia ◽  
1992 ◽  
Vol 12 (4) ◽  
pp. 257-258 ◽  
Author(s):  
Rachel Hering ◽  
Irit Gilad ◽  
Z Laron ◽  
A Kuritzky
Keyword(s):  
Growth Hormone ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Sodium Valproate ◽  
Cortisol Secretion ◽  
Healthy Controls ◽  
Normal Range ◽  
Migraine Group

A single oral dose of 500 mg sodium valproate had no effect on prolactin, growth hormone and cortisol secretion in 10 migraine patients when compared with five healthy controls and four migraine patients receiving placebo. Basal values of prolactin (PRL), cortisol and growth hormone (GH) were within the normal range, though PRL basal levels were lower in three patients (21.5%) in the migraine group.

Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice

2006 ◽  
Vol 290 (2) ◽  
pp. E317-E325 ◽  
Author(s):  
Emil Egecioglu ◽  
Mikael Bjursell ◽  
Anna Ljungberg ◽  
Suzanne L. Dickson ◽  
John J. Kopchick ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Food Intake ◽  
Growth Hormone Receptor ◽  
Hdl Cholesterol ◽  
Serum Levels ◽  
High Plasma ◽  
Littermate Control ◽  
Apo B ◽  
Gh Secretion ◽  
Increase Food Intake

We have previously shown that growth hormone (GH) overexpression in the brain increased food intake, accompanied with increased hypothalamic agouti-related protein (AgRP) expression. Ghrelin, which stimulates both appetite and GH secretion, was injected intracerebroventricularly to GHR−/− and littermate control (+/+) mice to determine whether ghrelin's acute effects on appetite are dependent on GHR signaling. GHR−/− mice were also analyzed with respect to serum levels of lipoproteins, apolipoprotein (apo)B, leptin, glucose, and insulin as well as body composition. Central injection of ghrelin into the third dorsal ventricle increased food consumption in +/+ mice, whereas no change was observed in GHR−/− mice. After ghrelin injection, AgRP mRNA expression in the hypothalamus was higher in +/+ littermates than in GHR−/− mice, indicating a possible importance of AgRP in the GHR-mediated effect of ghrelin. Compared with controls, GHR−/− mice had increased food intake, leptin levels, and total and intra-abdominal fat mass per body weight and deceased lean mass. Moreover, serum levels of triglycerides, LDL and HDL cholesterol, and apoB, as well as glucose and insulin levels were lower in the GHR−/− mice. In summary, ghrelin's acute central action to increase food intake requires functionally intact GHR signaling. Long-term GHR deficiency in mice is associated with high plasma leptin levels, obesity, and increased food intake but a marked decrease in all lipoprotein fractions.

scholarly journals Serum levels of doxycycline in normal subjects after a single oral dose.

BMJ ◽  
1976 ◽  
Vol 1 (6014) ◽  
pp. 880-880 ◽  
Author(s):  
B K Adadevoh ◽  
I A Ogunnaike ◽  
J O Bolodeoku
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Normal Subjects ◽  
Serum Levels

Regulation by catecholamines of spontaneous growth hormone secretion in the baboon

1981 ◽  
Vol 241 (3) ◽  
pp. E196-E199
Author(s):  
J. K. Stewart ◽  
D. J. Koerker ◽  
C. J. Goodner ◽  
C. C. Gale ◽  
M. F. Minton ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Serum Levels ◽  
Adolescent Male ◽  
Serum Prolactin ◽  
Base Line ◽  
Spontaneous Growth ◽  
Fourfold Increase ◽  
Gh Secretion

To gain an increased understanding of the role of central neurotransmitters in the regulation of spontaneous growth hormone (GH) secretion in the primate, we investigated the effects of peripheral intravenous infusion of the alpha-adrenergic receptor-blocking agent, phentolamine (5.0-mg bolus and 1.5 mg . kg-1 . 12 h-1), and the tyrosine hydroxylase inhibitor, alpha-methyl-p-tyrosine (MPT, 300 mg . kg-1 . 24 h-1), on the pattern of GH secretion in five adolescent male baboons. Serum GH concentrations were measured in blood samples taken at 20-min intervals over 12 h (0530–1730) after an overnight fast. In nontreatment control studies, GH secretion exhibited a predictable rhythmic oscillation with a mean period of 5.7 +/- 0.4 (SE) h. Phentolamine significantly decreased the 12-h mean and integrated GH concentrations compared to control values, but the small peaks of GH, which could be distinguished from base-line concentrations in three of the animals, occurred at the same time as during control studies. Whereas alpha-methyl-p-tyrosine slightly reduced serum levels of GH, it significantly increased the GH pulse frequency in the baboons. A two- to fourfold increase in serum prolactin levels occurred in all animals treated with MPT. These findings suggest that alpha-adrenergic pathways play a stimulatory role in maintaining spontaneous daytime GH secretion in the baboon and that one or more catecholamines are involved in the generation of rhythmic GH release.

Changes in brain levels of gonadotropin-releasing hormone and serum levels of gonadotropin and growth hormone in goldfish during spawning

1991 ◽  
Vol 69 (1) ◽  
pp. 182-188 ◽  
Author(s):  
K. L. Yu ◽  
C. Peng ◽  
R. E. Peter
Keyword(s):  
Growth Hormone ◽  
Temporal Correlation ◽  
Serum Levels ◽  
Gonadotropin Releasing Hormone ◽  
Neuronal System ◽  
Releasing Hormone ◽  
Gh Secretion ◽  
Floating Vegetation ◽  
Serum Gh ◽  
Sexually Mature

Changes in serum levels of gonadotropin (GtH) and growth hormone (GH) and in levels of gonadotropin-releasing hormone (GnRH) in the pituitary and discrete brain areas were studied in male goldfish during spawning with spontaneously ovulating females. Spontaneous ovulation in females was induced by raising water temperature from 12 to 20 °C and providing spawning substrate of artificial floating vegetation. Spawning occurs naturally in sexually mature male goldfish in the presence of ovulating females. Serum GtH levels in spawning male goldfish exposed to ovulatory females increased markedly in synchrony with the ovulatory GtH surge in females. There was also a significant increase in serum GH levels in the spawning males. GnRH levels in the olfactory bulbs, telencephalon, hypothalamus, and pituitary of the spawning males showed marked decreases at the same time as serum levels of both GtH and GH peaked; these events in the males corresponded to the approximate time of ovulation, and similar changes in serum GtH and GH levels and brain GnRH levels, in the females. This temporal correlation between changes in GnRH levels in the brain and pituitary and increases in serum levels of GtH and GH in males as well as females supports the idea that activation of the GnRH neuronal system may be a common pathway for the stimulation of pituitary GtH and GH secretion in goldfish during spawning.

Growth hormone, somatomedin levels and growth regulation in Turner's syndrome

1987 ◽  
Vol 116 (2) ◽  
pp. 305-313 ◽  
Author(s):  
Michael B. Ranke ◽  
Werner F. Blum ◽  
Frank Haug ◽  
Werner Rosendahl ◽  
Andrea Attanasio ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Regulation ◽  
Bone Age ◽  
Serum Levels ◽  
Turner's Syndrome ◽  
Turner’S Syndrome ◽  
Normal Range ◽  
Cross Sectional ◽  
Gh Secretion ◽  
Igf I

Abstract. In a total of 56 children and adolescents with Turner's syndrome (41 with karyotype 45,X) basal serum levels of somatomedin bioactivity, Sm-C/IGF-I (RIA), IGF II (RIA), GH response to arginine and GHRH (GRF(1-29)NH2), and spontaneous GH secretion during 5.5 h of deep sleep were determined in a cross-sectional manner. GH responses to GRF and arginine as well as IGF-II levels were found to be in the normal range. Levels of somatomedin bioactivity were higher than normal before a bone age of 10 years, in the low-normal range thereafter, and below normal in some patients. Levels of Sm-C/IGF-I were found normal before and low-normal after a bone age of ten years. There was a trend towards increasing Sm-C/IGF-I levels with age. In contrast to the normal pattern, spontaneous sleep-related GH secretion was declining with age and did not show the puberty-associated rise. These findings suggest a normally functioning growth hormone-somatomedin axis in Turner's syndrome with alterations of its functioning level occurring secondarily as a result of absent gonadal activation. In single patients abnormally low growth hormone and/or somatomedin secretion may be present.

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