Effect of disease duration on the association between serum albumin and mucosal healing in patients with ulcerative colitis

ObjectiveSerum albumin is used as a marker of acute inflammation. Several studies have addressed the association between serum albumin and clinical outcome in patients with ulcerative colitis (UC). While mucosal healing (MH) has been indicated as the therapeutic goal for UC, the association between serum albumin and MH remains unclear. We evaluated this issue in patients with UC overall and explored whether duration of UC affected this association.DesignThis cross-sectional study recruited consecutive patients with UC. Study subjects consisted of 273 Japanese patients with UC. Serum albumin was divided into tertiles based on its distribution in all study subjects. One endoscopy specialist was responsible for measuring partial MH and MH, which were defined as a Mayo endoscopic subscore of 0–1 and 0, respectively. The association between serum albumin and clinical outcomes was assessed by multivariate logistic regression.ResultsRates of clinical remission, partial MH and MH were 57.9%, 63% and 26%, respectively. Only high serum albumin (>4.4 mg/dL) was significantly positively associated with MH (OR 2.29 (95% CI: 1.03 to 5.29), p for trend=0.043). In patients with short UC duration (<7 years) only, high serum albumin was significantly positively associated with MH and clinical remission. In patients with long UC duration (≥7 years), in contrast, no association between serum albumin and clinical outcomes was found.ConclusionIn Japanese patients with UC, serum albumin was significantly positively associated with MH. In patients with short UC duration, serum albumin might be a useful complementary marker for MH.

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Association between eating habits and clinical outcome in patients with ulcerative colitis: A cross sectional study

10.21203/rs.3.rs-209163/v1 ◽

2021 ◽

Author(s):

Shinya Furukawa ◽

Sen Yagi ◽

Kana Shiraishi ◽

Yu Hashimoto ◽

Shogo Kitahata ◽

...

Keyword(s):

Ulcerative Colitis ◽

Clinical Outcome ◽

Clinical Remission ◽

Eating Habits ◽

A Priori ◽

Japanese Patients ◽

Cross Sectional Study ◽

Mucosal Healing ◽

Eating Rate ◽

Cross Sectional

Abstract Background: Although the association between eating habits which can be modified and digestive diseases has been reported, to date, no research has evaluated the association between eating habits and ulcerative colitis (UC). Thus, we investigate the association between eating behavior and clinical outcome in Japanese patients with UC.Methods: Eating quickly, eating until full, and skipping breakfast data was obtained from a self-administered questionnaire. Information on clinical outcome was collected from medical records. Mucosal healing (MH) and partial MH was defined as a Mayo endoscopic subscore of 0 or 0–1, respectively. Age, sex, BMI, current smoking, current drinking, steroid use, and anti-TNFα monoclonal antibody use were selected a priori as potential confounding factors.Results: Study subjects consisted of 294 Japanese patients with UC. Eating at speed moderate and eating quickly were independently inversely associated with MH: the adjusted odds ratios (ORs) were 0.38 (95% confidence interval [CI]: 0.16–0.85) and 0.38 (95% CI: 0.17–0.81) (p for trend = 0.033). Eating until full was independently inversely associated with MH: the adjusted OR was 0.38 (95% CI: 0.27–0.86). MH in patients who skipped breakfast was marginally lower than that in patients who did not skip breakfast. No association between eating habits and clinical remission or partial MH was found.Conclusion: Among patients with UC, eating rate and eating until full may be independently inversely associated with MH but not clinical remission.

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Association Between Platelet Count and Mucosal Healing in Japanese Patients With Ulcerative Colitis: Cross-Sectional Study

10.21203/rs.3.rs-60855/v1 ◽

2020 ◽

Author(s):

Shinya Furukawa ◽

Sen Yagi ◽

Kana Shiraishi ◽

Kenichirou Mori ◽

Tomoyuki Ninomiya ◽

...

Keyword(s):

Ulcerative Colitis ◽

Platelet Count ◽

Japanese Patients ◽

Cross Sectional Study ◽

Mucosal Healing ◽

Confounding Factors ◽

Cross Sectional ◽

Factor Α ◽

Very High ◽

Necrosis Factor

Abstract Background: Mucosal healing (MH) has been indicated as the therapeutic goal for ulcerative colitis (UC). Platelet count is known as an inflammation evaluation. However, the association between platelet count and MH among patients with UC is still scarce. We therefore assessed this issue among Japanese patients with UC.Methods: The study subjects consisted of 345 Japanese patients with UC. Platelet count was divided into quartiles on the basis of the distribution of all study subjects (low, moderate, high, and very high). Several endoscope specialists were responsible for evaluating MH and partial MH, which was defined as a Mayo endoscopic subscore of 0 and 0-1, respectively. Estimations of crude odds ratios (ORs) and their 95% confidence intervals (CIs) for partial MH and MH in relation to platelet count were performed using logistic regression analysis. Age, sex, CRP, steroid use, and anti-Tumor necrosis factor α (TNFα) preparation were selected a priori as potential confounding factors.Results: The percentage of partial MH and MH were 63.2 and 26.1%, respectively. Moderate and very high was independently inversely associated with partial MH (moderate: OR 0.40 [95%CI: 0.19-0.810], very high: OR 0.37 [95%CI: 0.17-0.77], p for trend= 0.034). Similarly, moderate, high, and very high were independently inversely associated with MH (moderate: OR 0.37 [95% CI: 0.18-0.73], high: OR 0.41 [95% CI: 0.19-0.83], and very high: OR 0.45 [95% CI: 0.21-0.94], p for trend = 0.033) after adjustment for confounding factors.Conclusions: Among patients with UC, platelet count was independently inversely associated with MH.

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Association between platelet count and mucosal healing in Japanese patients with ulcerative colitis: a cross-sectional study

BMC Gastroenterology ◽

10.1186/s12876-020-01538-y ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Shinya Furukawa ◽

Sen Yagi ◽

Kana Shiraishi ◽

Kenichirou Mori ◽

Tomoyuki Ninomiya ◽

...

Keyword(s):

Ulcerative Colitis ◽

Platelet Count ◽

A Priori ◽

Japanese Patients ◽

Cross Sectional Study ◽

Mucosal Healing ◽

Confounding Factors ◽

Cross Sectional ◽

Factor Α ◽

Very High

Abstract Background Mucosal healing (MH) has been indicated as the therapeutic goal for ulcerative colitis (UC). Platelet count is known as an inflammation evaluation. However, the association between platelet count and MH among patients with UC is still scarce. We therefore assessed this issue among Japanese patients with UC. Methods The study subjects consisted of 345 Japanese patients with UC. Platelet count was divided into quartiles on the basis of the distribution of all study subjects (low, moderate, high, and very high). Several endoscope specialists were responsible for evaluating MH and partial MH, which was defined as a Mayo endoscopic subscore of 0 and 0–1, respectively. Estimations of crude odds ratios (ORs) and their 95% confidence intervals (CIs) for partial MH and MH in relation to platelet count were performed using logistic regression analysis. Age, sex, CRP, steroid use, and anti-Tumor necrosis factor α (TNFα) preparation were selected a priori as potential confounding factors. Results The percentage of partial MH and MH were 63.2 and 26.1%, respectively. Moderate and very high was independently inversely associated with partial MH (moderate: OR 0.40 [95%CI 0.19–0.810], very high: OR 0.37 [95%CI 0.17–0.77], p for trend = 0.034). Similarly, moderate, high, and very high were independently inversely associated with MH (moderate: OR 0.37 [95% CI 0.18–0.73], high: OR 0.41 [95% CI 0.19–0.83], and very high: OR 0.45 [95% CI 0.21–0.94], p for trend = 0.033) after adjustment for confounding factors. Conclusions Among patients with UC, platelet count was independently inversely associated with MH

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Association between platelet count and mucosal healing in Japanese patients with ulcerative colitis: A cross-sectional study

10.21203/rs.3.rs-60855/v2 ◽

2020 ◽

Author(s):

Shinya Furukawa ◽

Sen Yagi ◽

Kana Shiraishi ◽

Kenichirou Mori ◽

Tomoyuki Ninomiya ◽

...

Keyword(s):

Ulcerative Colitis ◽

Platelet Count ◽

Japanese Patients ◽

Cross Sectional Study ◽

Mucosal Healing ◽

Confounding Factors ◽

Cross Sectional ◽

Factor Α ◽

Very High ◽

Necrosis Factor

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Association between serum bilirubin and mucosal healing among Japanese patients with ulcerative colitis: a cross-sectional study

International Journal of Colorectal Disease ◽

10.1007/s00384-020-03774-w ◽

2020 ◽

Author(s):

Kana Shiraishi ◽

Shinya Furukawa ◽

Sen Yagi ◽

Masakazu Hanayama ◽

Kenichirou Mori ◽

...

Keyword(s):

Ulcerative Colitis ◽

Serum Bilirubin ◽

Japanese Patients ◽

Cross Sectional Study ◽

Mucosal Healing ◽

Sectional Study ◽

Cross Sectional

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Association between platelet count and mucosal healing in Japanese patients with ulcerative colitis: A cross-sectional study

10.21203/rs.3.rs-60855/v3 ◽

2020 ◽

Author(s):

Shinya Furukawa ◽

Sen Yagi ◽

Kana Shiraishi ◽

Kenichirou Mori ◽

Tomoyuki Ninomiya ◽

...

Keyword(s):

Ulcerative Colitis ◽

Platelet Count ◽

A Priori ◽

Japanese Patients ◽

Cross Sectional Study ◽

Mucosal Healing ◽

Confounding Factors ◽

Cross Sectional ◽

Factor Α ◽

Very High

Abstract Background: Mucosal healing (MH) has been indicated as the therapeutic goal for ulcerative colitis (UC). Platelet count is known as an inflammation evaluation. However, the association between platelet count and MH among patients with UC is still scarce. We therefore assessed this issue among Japanese patients with UC. Methods: The study subjects consisted of 345 Japanese patients with UC. Platelet count was divided into quartiles on the basis of the distribution of all study subjects (low, moderate, high, and very high). Several endoscope specialists were responsible for evaluating MH and partial MH, which was defined as a Mayo endoscopic subscore of 0 and 0-1, respectively. Estimations of crude odds ratios (ORs) and their 95% confidence intervals (CIs) for partial MH and MH in relation to platelet count were performed using logistic regression analysis. Age, sex, CRP, steroid use, and anti-Tumor necrosis factor α (TNFα) preparation were selected a priori as potential confounding factors. Results: The percentage of partial MH and MH were 63.2 and 26.1%, respectively. Moderate and very high was independently inversely associated with partial MH (moderate: OR 0.40 [95%CI: 0.19-0.810], very high: OR 0.37 [95%CI: 0.17-0.77], p for trend= 0.034). Similarly, moderate, high, and very high were independently inversely associated with MH (moderate: OR 0.37 [95% CI: 0.18-0.73], high: OR 0.41 [95% CI: 0.19-0.83], and very high: OR 0.45 [95% CI: 0.21-0.94], p for trend = 0.033) after adjustment for confounding factors. Conclusions: Among patients with UC, platelet count was independently inversely associated with MH.

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Fecal Calprotectin Thresholds to Predict Endoscopic Remission Using Advanced Optical Enhancement Techniques and Histological Remission in IBD Patients

Inflammatory Bowel Diseases ◽

10.1093/ibd/izaa163 ◽

2020 ◽

Author(s):

Rosanna Cannatelli ◽

Alina Bazarova ◽

Davide Zardo ◽

Olga Maria Nardone ◽

Uday Shivaji ◽

...

Keyword(s):

Ulcerative Colitis ◽

Surrogate Marker ◽

Fecal Calprotectin ◽

Cross Sectional Study ◽

Mucosal Healing ◽

Cross Sectional ◽

Endoscopic Techniques ◽

Endoscopic Remission ◽

Endoscopic Score ◽

Histological Remission

Abstract Background Fecal calprotectin (FC) is a common surrogate marker of mucosal healing (MH) in patients with ulcerative colitis (UC) and Crohn’s disease (CD). We investigated the optimum FC thresholds for defining endoscopic remission (ER) and histological remission (HR) using advanced endoscopic techniques. Patients and Methods In this cross-sectional study, we collected clinical, endoscopic, histological data, and FC from 76 UC and 41 CD patients. Receiver operating characteristic curves were created to evaluate the optimum cut-off of FC to predict ER evaluated by Mayo Endoscopic Score (MES), Ulcerative Colitis Endoscopic Index of Severity (UCEIS), and modified PICaSSO (Paddington International Virtual Chromoendoscopy Score) for UC patients and Simple Endoscopic Score (SES-CD) in CD patients; and HR was scored by the Robarts Histology Index (RHI) and Nancy Index for UC and modified Riley for CD. Results In UC patients, the best thresholds of FC to identify ER calculated with MES, UCEIS, and modified PICaSSO were 112, 148, and 161 mcg/g with accuracy of 86.9% 86.8%, and 81.6%, respectively. The best value of FC to predict HR was 112 mcg/g and 172 mcg/g with accuracy of 84.2% and 81.6% for RHI and Nancy Index, respectively. In CD patients, the best cut-off of FC to predict ER was 96 mcg/g with accuracy of 82.9%. The HR was best predicted by an FC value of 225 mcg/g with accuracy of 75.6%. Conclusions The FC value threshold between 112 and 172 mcg/g could identify ER and HR in UC patients, whereas a value under 225 mcg/g should be considered for CD patients.

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The inverse association between unhealthy eating habit and mucosal healing among patients with ulcerative colitis

BMC Gastroenterology ◽

10.1186/s12876-021-01724-6 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Shinya Furukawa ◽

Sen Yagi ◽

Kana Shiraishi ◽

Yu Hashimoto ◽

Shogo Kitahata ◽

...

Keyword(s):

Ulcerative Colitis ◽

Clinical Outcome ◽

Clinical Remission ◽

Eating Habits ◽

A Priori ◽

Japanese Patients ◽

Mucosal Healing ◽

Inverse Association ◽

Eating Rate ◽

Unhealthy Eating

Abstract Background Although the association between eating habits which can be modified and digestive diseases has been reported, to date, no research has evaluated the association between eating habits and ulcerative colitis (UC). Thus, we investigate the association between eating behavior and clinical outcome in Japanese patients with UC. Methods Eating quickly, eating until full, and skipping breakfast data was obtained from a self-administered questionnaire. Information on clinical outcome was collected from medical records. Mucosal healing (MH) and partial MH was defined as a Mayo endoscopic subscore of 0 or 0–1, respectively. Age, sex, BMI, current smoking, current drinking, prednisolone use, and anti-TNFα monoclonal antibody use were selected a priori as potential confounding factors. Results Study subjects consisted of 294 Japanese patients with UC. Eating at speed moderate and eating quickly were independently inversely associated with MH: the adjusted odds ratios (ORs) were 0.38 (95% confidence interval [CI] 0.16–0.85) and 0.38 (95% CI 0.17–0.81) (p for trend = 0.033). Eating until full was independently inversely associated with MH: the adjusted OR was 0.38 (95% CI 0.27–0.86). MH in patients who skipped breakfast was marginally lower than that in patients who did not skip breakfast. No association between eating habits and clinical remission or partial MH was found. Conclusion Among patients with UC, eating rate and eating until full may be independently inversely associated with MH but not clinical remission.

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The albumin to globulin ratio is associated with mucosal healing in Japanese patients with ulcerative colitis: A cross-sectional study

10.21203/rs.3.rs-144470/v1 ◽

2021 ◽

Author(s):

Sen Yagi ◽

Shinya Furukawa ◽

Kana Shiraishi ◽

Masakazu Hanayama ◽

Kazuhiro Tange ◽

...

Keyword(s):

Ulcerative Colitis ◽

Age At Onset ◽

Japanese Patients ◽

Mucosal Healing ◽

Confounding Factors ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Protein Group ◽

Albumin To Globulin Ratio

Abstract Background Ulcerative colitis (UC) is a chronic inflammatory disease. Mucosal healing (MH) is inversely associated with clinical outcome. The albumin to globulin ratio (AGR) is known as chronic inflammation marker. While some evidence regarding an association between AGR and some chronic diseases has been reported, no evidence regarding association between AGR and UC exists. The aim of this study to evaluated the association between AGR and MH among Japanese patients with UC. Methods The study subjects consisted of 273 Japanese patients with UC. AGR was divided into quartiles on the basis of the distribution of all study subjects. One endoscopic specialist was responsible for evaluating MH, which was defined as a Mayo endoscopic subscore of 0 or 0–1. Age, sex, steroid use, body mass index, age at onset of UC, and anti-TNFα preparation were selected a priori as potential confounding factors. Results The mean age was 51.2 years, and the percentage of male patients was 59.0%. The percentage of MH was 26.4%. High AGR (1.483 < AGR ≤ 1.643) and very high AGR (> 1.643) was significantly positively associated with MH (OR 2.21 [95% CI: 1.12–4.47], p for trend = 0.001) after adjustment for confounding factors. No association between AGR and partial MH was found. The independent positive association between AGR and MH was found in only low C-reactive protein group. Conclusion Among Japanese patients with UC, AGR was significantly positively associated with MH, was significantly positively associated with MH especially in the low C-reactive protein group.

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