scholarly journals Design and baseline characteristics of the PODOSA (Prevention of Diabetes & Obesity in South Asians) trial: a cluster, randomised lifestyle intervention in Indian and Pakistani adults with impaired glycaemia at high risk of developing type 2 diabetes

BMJ Open ◽  
2013 ◽  
Vol 3 (2) ◽  
pp. e002226 ◽  
Author(s):  
Anne Douglas ◽  
Raj S Bhopal ◽  
Ruby Bhopal ◽  
John F Forbes ◽  
Jason M R Gill ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
High Risk ◽  
Lifestyle Intervention ◽  
South Asians ◽  
Cluster Randomised ◽  
Baseline Characteristics ◽  
Prevention Of Diabetes

scholarly journals Different Effects of Lifestyle Intervention in High- and Low-Risk Prediabetes

2021 ◽  
Author(s):  
Andreas Fritsche ◽  
Robert Wagner ◽  
Martin Heni ◽  
Kostantinos Kantartzis ◽  
Jürgen Machann ◽  
...  
Keyword(s):  
High Risk ◽  
Lifestyle Intervention ◽  
Low Risk ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Randomized Controlled ◽  
The Difference ◽  
Prevention Of Diabetes

Lifestyle intervention (LI) can prevent type 2 diabetes, but response to LI varies depending on risk subphenotypes. We tested if prediabetic individuals with low risk benefit from conventional LI and individuals with high risk benefit from an intensification of LI in a multi-center randomized controlled intervention over 12 months with 2 years follow up. 1105 prediabetic individuals based on ADA glucose criteria were stratified into a high- and low-risk phenotype, based on previously described thresholds of insulin secretion, insulin sensitivity and liver fat content. Low-risk individuals were randomly assigned to conventional LI according to the DPP protocol or control (1:1), high-risk individuals to conventional or intensified LI with doubling of required exercise (1:1). A total of 908 (82%) participants completed the study. In high-risk individuals, the difference between conventional and intensified LI in post-challenge glucose change was -0.29 mmol/l [CI:-0.54;-0.04], p=0.025. Liver fat (-1.34 percentage points [CI:-2.17;-0.50], p=0.002) and cardiovascular risk (-1.82[CI:-3.13-0.50],p=0.007) underwent larger reductions with intensified than with conventional LI. During a follow up of 3 years, intensified compared to conventional LI had a higher probability to normalize glucose tolerance (p=0.008). In conclusion, it is possible in high-risk individuals with prediabetes to improve glycemic and cardiometabolic outcomes by intensification of LI. Individualized, risk-phenotype-based LI may be beneficial for the prevention of diabetes.

scholarly journals Different Effects of Lifestyle Intervention in High- and Low-Risk Prediabetes

2021 ◽  
Author(s):  
Andreas Fritsche ◽  
Robert Wagner ◽  
Martin Heni ◽  
Kostantinos Kantartzis ◽  
Jürgen Machann ◽  
...  
Keyword(s):  
High Risk ◽  
Lifestyle Intervention ◽  
Low Risk ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Randomized Controlled ◽  
The Difference ◽  
Prevention Of Diabetes

Lifestyle intervention (LI) can prevent type 2 diabetes, but response to LI varies depending on risk subphenotypes. We tested if prediabetic individuals with low risk benefit from conventional LI and individuals with high risk benefit from an intensification of LI in a multi-center randomized controlled intervention over 12 months with 2 years follow up. 1105 prediabetic individuals based on ADA glucose criteria were stratified into a high- and low-risk phenotype, based on previously described thresholds of insulin secretion, insulin sensitivity and liver fat content. Low-risk individuals were randomly assigned to conventional LI according to the DPP protocol or control (1:1), high-risk individuals to conventional or intensified LI with doubling of required exercise (1:1). A total of 908 (82%) participants completed the study. In high-risk individuals, the difference between conventional and intensified LI in post-challenge glucose change was -0.29 mmol/l [CI:-0.54;-0.04], p=0.025. Liver fat (-1.34 percentage points [CI:-2.17;-0.50], p=0.002) and cardiovascular risk (-1.82[CI:-3.13-0.50],p=0.007) underwent larger reductions with intensified than with conventional LI. During a follow up of 3 years, intensified compared to conventional LI had a higher probability to normalize glucose tolerance (p=0.008). In conclusion, it is possible in high-risk individuals with prediabetes to improve glycemic and cardiometabolic outcomes by intensification of LI. Individualized, risk-phenotype-based LI may be beneficial for the prevention of diabetes.

scholarly journals Different Effects of Lifestyle Intervention in High- and Low-Risk Prediabetes

2021 ◽  
Author(s):  
Andreas Fritsche ◽  
Robert Wagner ◽  
Martin Heni ◽  
Kostantinos Kantartzis ◽  
Jürgen Machann ◽  
...  
Keyword(s):  
High Risk ◽  
Lifestyle Intervention ◽  
Low Risk ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Randomized Controlled ◽  
The Difference ◽  
Prevention Of Diabetes

Lifestyle intervention (LI) can prevent type 2 diabetes, but response to LI varies depending on risk subphenotypes. We tested if prediabetic individuals with low risk benefit from conventional LI and individuals with high risk benefit from an intensification of LI in a multi-center randomized controlled intervention over 12 months with 2 years follow up. 1105 prediabetic individuals based on ADA glucose criteria were stratified into a high- and low-risk phenotype, based on previously described thresholds of insulin secretion, insulin sensitivity and liver fat content. Low-risk individuals were randomly assigned to conventional LI according to the DPP protocol or control (1:1), high-risk individuals to conventional or intensified LI with doubling of required exercise (1:1). A total of 908 (82%) participants completed the study. In high-risk individuals, the difference between conventional and intensified LI in post-challenge glucose change was -0.29 mmol/l [CI:-0.54;-0.04], p=0.025. Liver fat (-1.34 percentage points [CI:-2.17;-0.50], p=0.002) and cardiovascular risk (-1.82[CI:-3.13-0.50],p=0.007) underwent larger reductions with intensified than with conventional LI. During a follow up of 3 years, intensified compared to conventional LI had a higher probability to normalize glucose tolerance (p=0.008). In conclusion, it is possible in high-risk individuals with prediabetes to improve glycemic and cardiometabolic outcomes by intensification of LI. Individualized, risk-phenotype-based LI may be beneficial for the prevention of diabetes.

scholarly journals Effects of telephone-delivered lifestyle support on the development of diabetes in participants at high risk of type 2 diabetes: J-DOIT1, a pragmatic cluster randomised trial

BMJ Open ◽  
2015 ◽  
Vol 5 (8) ◽  
pp. e007316 ◽  
Author(s):  
Naoki Sakane ◽  
Kazuhiko Kotani ◽  
Kaoru Takahashi ◽  
Yoshiko Sano ◽  
Kokoro Tsuzaki ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
High Risk ◽  
Randomised Trial ◽  
Cluster Randomised Trial ◽  
Cluster Randomised

The importance of type 2 diabetes prevention: The Norfolk Diabetes Prevention Study

2011 ◽  
Vol 11 (6) ◽  
pp. 308-313 ◽  
Author(s):  
Nikki J Murray ◽  
Sara Abadi ◽  
Aliceon Blair ◽  
Melanie Dunk ◽  
Mike J Sampson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
High Risk ◽  
Lifestyle Intervention ◽  
Diabetes Prevention ◽  
Controlled Trial ◽  
Activity Levels ◽  
Prevention Study ◽  
Diabetes Prevention Study ◽  
Diet And Lifestyle

Many large studies have investigated the prevention of type 2 diabetes in people at high risk of the condition, usually with changes in diet and physical activity levels. It is estimated that 2.25 million people in the UK have type 2 diabetes, with significant personal and healthcare costs, and the value of preventative measures in tackling this enormous public health challenge are well described. The Norfolk Diabetes Prevention Study (Norfolk DPS) will screen 10,000 people at risk of type 2 diabetes over five years, randomising 950 people with ‘pre-diabetes’ into a 36-month randomised controlled trial (three-armed study) of a novel diet and lifestyle intervention. The Norfolk DPS team is multidisciplinary and the intervention will be delivered by healthcare professionals in group settings. One arm will be part delivered by lay mentors who have existing type 2 diabetes. There is no UK-validated diet and lifestyle intervention for the prevention of type 2 diabetes in high risk groups that has been tested in a controlled trial, and an intervention delivered by those with existing type 2 diabetes has not been studied. The Norfolk DPS will provide further evidence in these areas.

Sign in / Sign up

Export Citation Format

Share Document