scholarly journals A population-based case–control study on social factors and risk of testicular germ cell tumours

BMJ Open ◽  
2013 ◽  
Vol 3 (9) ◽  
pp. e003833 ◽  
Author(s):  
Nils Schmeisser ◽  
David I Conway ◽  
Andreas Stang ◽  
Ingeborg Jahn ◽  
Christa Stegmaier ◽  
...  
Keyword(s):  
Germ Cell ◽  
Social Factors ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Germ Cell Tumours ◽  
Testicular Germ Cell ◽  
Testicular Germ Cell Tumours ◽  
Control Study

scholarly journals Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case–control study in Finland, Norway, and Sweden

2021 ◽  
Author(s):  
Sara Corbin ◽  
Kayo Togawa ◽  
Joachim Schüz ◽  
Charlotte Le Cornet ◽  
Beatrice Fervers ◽  
...  
Keyword(s):  
Germ Cell ◽  
Case Control Study ◽  
Occupational Exposures ◽  
Case Control ◽  
Germ Cell Tumours ◽  
Prenatal Exposures ◽  
Testicular Germ Cell ◽  
Testicular Germ Cell Tumours ◽  
Increased Risk ◽  
Control Study

Abstract Objective We assessed the association between parental prenatal exposures in wood-related jobs and risk of testicular germ cell tumours (TGCT) in offspring. Methods NORD-TEST, a registry-based case–control study in Sweden, Finland and Norway, included 8112 TGCT cases diagnosed at ages 14–49 years between 1978 and 2012 with no history of prior cancer, and up to four controls matched to each case on year and country of birth. Parents of cases and controls were identified via linkages with the population registries and their occupational information was retrieved from censuses. The Nordic Occupational Cancer Study Job-Exposure Matrix was used to assign occupational exposures to each parent. Logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results Maternal wood-related job was not associated with the risk of TGCT in offspring (OR 1.08, CI 0.55–2.14), while paternal wood-related job was associated with a decreased risk of TGCT in offspring (OR 0.85, CI 0.75–0.96). None of the specific wood-related jobs, such as upholsterers, sawyers, or construction carpenters, were significantly associated with a risk of TGCT. Only exception was observed in a sensitivity analysis which showed an increased risk in the small group of sons of fathers working as ‘cabinetmakers and joiners’ the year before conception (OR of 2.06, CI 1.00–4.25). Conclusion This large-scale NORD-TEST analysis provided no evidence of an association between parental prenatal exposures in wood-related jobs and TGCT in sons.

The Inter-Regional, Epidemiological Study of Childhood Cancer (IRESCC): case-control study in children with germ cell tumours

1986 ◽  
Vol 7 (5) ◽  
pp. 717-722 ◽  
Author(s):  
H.E. Johnston ◽  
J.R. Mann ◽  
J. Williams ◽  
J.A.H. Waterhouse ◽  
J.M. Birch ◽  
...  
Keyword(s):  
Germ Cell ◽  
Childhood Cancer ◽  
Epidemiological Study ◽  
Case Control Study ◽  
Case Control ◽  
Germ Cell Tumours ◽  
Control Study

scholarly journals Outcome of patients with HIV-related germ cell tumours: a case–control study

2004 ◽  
Vol 90 (8) ◽  
pp. 1526-1530 ◽  
Author(s):  
T Powles ◽  
M Bower ◽  
J Shamash ◽  
J Stebbing ◽  
J Ong ◽  
...  
Keyword(s):  
Germ Cell ◽  
Case Control Study ◽  
Case Control ◽  
Germ Cell Tumours ◽  
Control Study

scholarly journals Domestic use of pesticides during early periods of development and risk of testicular germ cell tumors in adulthood: a French nationwide case-control study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Aurélie M. N. Danjou ◽  
Olivia Pérol ◽  
Astrid Coste ◽  
Elodie Faure ◽  
Rémi Béranger ◽  
...  
Keyword(s):  
Germ Cell ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Germ Cell Tumors ◽  
Developed Countries ◽  
Case Control ◽  
Testicular Germ Cell ◽  
Increased Risk ◽  
Domestic Use ◽  
Control Study

Abstract Background Testicular germ cell tumours (TGCT) are the most frequent cancers in young men in developed countries and their incidence rate has doubled worldwide over the past 40 years. Early life exposures to pesticides are suspected to increase TGCT risk. Our research aimed at estimating adult TGCT risk associated with parental domestic use of pesticides during early periods of child development. Methods We conducted a case-control study of 304 TGCT cases, aged 18–45 years old, recruited in 20 French university hospitals, and 274 controls frequency-matched on hospital and birth year. Participants’ mothers provided information on their domestic use of pesticides from 1 year before start of pregnancy to 1 year after their son’s birth, for gardening activities, treatment of indoor plants, pets, wood and mold, and pest control. Odds ratios (OR) for TGCT (overall and by histological subtype) and 95% confidence intervals (CI) were estimated using conditional logistic regression. Results Prevalence of reported domestic use of pesticides was 77.3% for insecticides, 15.9% for fungicides and 12.1% for herbicides. While no association was found for any use of insecticides (OR = 1.27, CI = 0.80–2.01) or herbicides (OR = 1.15, CI = 0.67–2.00), elevated risks of TGCT overall (OR = 1.73, CI = 1.04–2.87) and non-seminoma subtype (OR = 2.44, CI = 1.26–4.74) were observed for any use of fungicides. When specific purposes were examined, using fungicides and/or insecticides for woodwork (OR = 2.35, CI = 1.06–5.20) and using insecticides on cats and dogs (OR = 1.95, CI = 1.12–3.40) were associated with increased risk of non-seminoma subtype. We found no association for seminoma subtype. Conclusions Although recall bias may partially explain the elevated ORs, our study provides some evidence of a positive association between domestic use of pesticides during early periods of development, particularly fungicides and risk of adult TGCT and non-seminoma. Given the common domestic use of pesticides in France, further research on TGCT risk is warranted.

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