scholarly journals Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case–control study in Finland, Norway, and Sweden

2021 ◽  
Author(s):  
Sara Corbin ◽  
Kayo Togawa ◽  
Joachim Schüz ◽  
Charlotte Le Cornet ◽  
Beatrice Fervers ◽  
...  
Keyword(s):  
Germ Cell ◽  
Case Control Study ◽  
Occupational Exposures ◽  
Case Control ◽  
Germ Cell Tumours ◽  
Prenatal Exposures ◽  
Testicular Germ Cell ◽  
Testicular Germ Cell Tumours ◽  
Increased Risk ◽  
Control Study

Abstract Objective We assessed the association between parental prenatal exposures in wood-related jobs and risk of testicular germ cell tumours (TGCT) in offspring. Methods NORD-TEST, a registry-based case–control study in Sweden, Finland and Norway, included 8112 TGCT cases diagnosed at ages 14–49 years between 1978 and 2012 with no history of prior cancer, and up to four controls matched to each case on year and country of birth. Parents of cases and controls were identified via linkages with the population registries and their occupational information was retrieved from censuses. The Nordic Occupational Cancer Study Job-Exposure Matrix was used to assign occupational exposures to each parent. Logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results Maternal wood-related job was not associated with the risk of TGCT in offspring (OR 1.08, CI 0.55–2.14), while paternal wood-related job was associated with a decreased risk of TGCT in offspring (OR 0.85, CI 0.75–0.96). None of the specific wood-related jobs, such as upholsterers, sawyers, or construction carpenters, were significantly associated with a risk of TGCT. Only exception was observed in a sensitivity analysis which showed an increased risk in the small group of sons of fathers working as ‘cabinetmakers and joiners’ the year before conception (OR of 2.06, CI 1.00–4.25). Conclusion This large-scale NORD-TEST analysis provided no evidence of an association between parental prenatal exposures in wood-related jobs and TGCT in sons.

scholarly journals A population-based case–control study on social factors and risk of testicular germ cell tumours

BMJ Open ◽  
2013 ◽  
Vol 3 (9) ◽  
pp. e003833 ◽  
Author(s):  
Nils Schmeisser ◽  
David I Conway ◽  
Andreas Stang ◽  
Ingeborg Jahn ◽  
Christa Stegmaier ◽  
...  
Keyword(s):  
Germ Cell ◽  
Social Factors ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Germ Cell Tumours ◽  
Testicular Germ Cell ◽  
Testicular Germ Cell Tumours ◽  
Control Study

scholarly journals Domestic use of pesticides during early periods of development and risk of testicular germ cell tumors in adulthood: a French nationwide case-control study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Aurélie M. N. Danjou ◽  
Olivia Pérol ◽  
Astrid Coste ◽  
Elodie Faure ◽  
Rémi Béranger ◽  
...  
Keyword(s):  
Germ Cell ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Germ Cell Tumors ◽  
Developed Countries ◽  
Case Control ◽  
Testicular Germ Cell ◽  
Increased Risk ◽  
Domestic Use ◽  
Control Study

Abstract Background Testicular germ cell tumours (TGCT) are the most frequent cancers in young men in developed countries and their incidence rate has doubled worldwide over the past 40 years. Early life exposures to pesticides are suspected to increase TGCT risk. Our research aimed at estimating adult TGCT risk associated with parental domestic use of pesticides during early periods of child development. Methods We conducted a case-control study of 304 TGCT cases, aged 18–45 years old, recruited in 20 French university hospitals, and 274 controls frequency-matched on hospital and birth year. Participants’ mothers provided information on their domestic use of pesticides from 1 year before start of pregnancy to 1 year after their son’s birth, for gardening activities, treatment of indoor plants, pets, wood and mold, and pest control. Odds ratios (OR) for TGCT (overall and by histological subtype) and 95% confidence intervals (CI) were estimated using conditional logistic regression. Results Prevalence of reported domestic use of pesticides was 77.3% for insecticides, 15.9% for fungicides and 12.1% for herbicides. While no association was found for any use of insecticides (OR = 1.27, CI = 0.80–2.01) or herbicides (OR = 1.15, CI = 0.67–2.00), elevated risks of TGCT overall (OR = 1.73, CI = 1.04–2.87) and non-seminoma subtype (OR = 2.44, CI = 1.26–4.74) were observed for any use of fungicides. When specific purposes were examined, using fungicides and/or insecticides for woodwork (OR = 2.35, CI = 1.06–5.20) and using insecticides on cats and dogs (OR = 1.95, CI = 1.12–3.40) were associated with increased risk of non-seminoma subtype. We found no association for seminoma subtype. Conclusions Although recall bias may partially explain the elevated ORs, our study provides some evidence of a positive association between domestic use of pesticides during early periods of development, particularly fungicides and risk of adult TGCT and non-seminoma. Given the common domestic use of pesticides in France, further research on TGCT risk is warranted.

scholarly journals Bladder cancer and occupational exposure to metalworking fluid mist: a counter-matched case–control study in French steel-producing factories

2018 ◽  
Vol 75 (5) ◽  
pp. 328-336 ◽  
Author(s):  
Régis Colin ◽  
Michel Grzebyk ◽  
Pascal Wild ◽  
Guy Hédelin ◽  
Ève Bourgkard
Keyword(s):  
Bladder Cancer ◽  
Occupational Exposure ◽  
Case Control Study ◽  
Occupational Exposures ◽  
Case Control ◽  
Metalworking Fluids ◽  
Cumulative Exposure ◽  
Cancer Case ◽  
Increased Risk ◽  
Control Study

ObjectivesTo assess the relationship between occupational exposure to metalworking fluids (MWFs) in the steel-producing industry and bladder cancer incidence.MethodsA nested case–control study on bladder cancer was set up in a cohort of workers from six French steel-producing factories. Three controls were randomly selected for each incident bladder cancer case diagnosed from 2006 to 2012. Controls were matched to cases on age at diagnosis and counter-matched on a surrogate measure of exposure to MWFs derived from a job-exposure matrix. Cases (n=84) and controls (n=251) were face-to-face interviewed. Experts assessed occupational exposure to MWFs (straight, soluble and synthetic) using questionnaires and reports from factory visits. Occupational exposures were based on three metrics: duration, frequency-weighted duration and cumulative exposure index. Conditional multiple logistic regressions were used to determine ORs and 95% CIs, taking non-occupational and occupational exposure into account.ResultsIn the 25 years before diagnosis, ORs increased significantly with duration of exposure to straight MWFs (OR=1.13 (1.02–1.25)) and increased with frequency-weighted duration of exposure to straight MWFs (OR=1.44 (0.97–2.14)). These results remained valid after adjusting for duration of smoking, average number of cigarettes smoked per day, time since smoking cessation and exposure to polycyclic aromatic hydrocarbons (PAHs). ORs also increased with soluble MWFs but not significantly. No significant association was found with older exposures to MWFs or with exposure to synthetic MWFs.ConclusionThe increased risk of bladder cancer observed among workers exposed to straight MWFs and to a lesser extent to soluble MWFs may be explained by the presence of carcinogens (such as PAH) in mineral oils component of straight and soluble oils. Prevention therefore remains necessary in sectors using MWFs.

The Inter-Regional, Epidemiological Study of Childhood Cancer (IRESCC): case-control study in children with germ cell tumours

1986 ◽  
Vol 7 (5) ◽  
pp. 717-722 ◽  
Author(s):  
H.E. Johnston ◽  
J.R. Mann ◽  
J. Williams ◽  
J.A.H. Waterhouse ◽  
J.M. Birch ◽  
...  
Keyword(s):  
Germ Cell ◽  
Childhood Cancer ◽  
Epidemiological Study ◽  
Case Control Study ◽  
Case Control ◽  
Germ Cell Tumours ◽  
Control Study

scholarly journals Occupational and Environmental Risk Factors for Idiopathic Pulmonary Fibrosis: A Multicenter Case-Control Study

2000 ◽  
Vol 152 (4) ◽  
pp. 307-315 ◽  
Author(s):  
Kathy B. Baumgartner ◽  
Jonathan M. Samet ◽  
David B. Coultas ◽  
Christine A. Stidley ◽  
William C. Hunt ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Case Control Study ◽  
Occupational Exposures ◽  
Case Control ◽  
Geographic Region ◽  
Unknown Etiology ◽  
Occupational Factors ◽  
Increased Risk ◽  
Control Study

Abstract Occupational exposures were investigated in a multicenter case-control study of clinically and histologically diagnosed idiopathic pulmonary fibrosis (IPF), a chronic diffuse interstitial lung disease of unknown etiology. Results are based on 248 cases, aged 20–75 years, diagnosed at 16 referral centers between January 1989 and July 1993. There were 491 controls ascertained by random digit dialing and matched to cases on sex, age, and geographic region. Data were collected using a standard telephone questionnaire. Occupational factors were based on a detailed history of jobs lasting 6 months or more and job activity, hobby, and specific substance checklists. Several occupational factors, adjusted for age and smoking in conditional multivariate logistic regression analyses, were significantly associated with IPF: farming (odds ratio (OR) = 1.6, 95% confidence interval (CI): 1.0, 2.5); livestock (OR = 2.7, 95% CI: 1.3, 5.5); hairdressing (OR = 4.4, 95% CI: 1.2, 16.3); metal dust (OR = 2.0, 95% CI: 1.0, 4.0); raising birds (OR = 4.7, 95% CI: 1.6, 14.1); stone cutting/polishing (OR = 3.9, 95% CI: 1.2, 12.7); and vegetable dust/animal dust (OR = 4.7, 95% CI: 2.1, 10.4). Interaction was detected between smoking and exposure to livestock (p = 0.06) and farming (p = 0.08). Results confirm previous studies showing increased risk associated with dusty environments. Am J Epidemiol 2000;152:307–15.

scholarly journals Is Chronic Exposure to Raw Water a Possible Risk Factor for Amyotrophic Lateral Sclerosis? A Pilot Case-Control Study

2021 ◽  
Vol 11 (2) ◽  
pp. 193
Author(s):  
Giuseppe Stipa ◽  
Antonio Ancidoni ◽  
Monica Mazzola ◽  
Emanuela Testai ◽  
Enzo Funari ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Case Control Study ◽  
Pesticide Exposure ◽  
Occupational Exposures ◽  
Case Control ◽  
Raw Water ◽  
Increased Risk ◽  
Tight Association ◽  
Control Study ◽  
Lateral Sclerosis

Background: The etiopathogenesis of amyotrophic lateral sclerosis (ALS) is still largely unknown. Methods: We performed a case-control study (33 cases and 35 controls) in Umbria, Italy. We investigated associations between common lifestyle, clinical factors, as well as environmental exposures potentially implicated with ALS onset. Face-to-face interviews were carried out. All cases were recruited and diagnosed according to El Escorial criteria. Case-control comparisons were made for educational and residential status, occupational exposures, and clinical and lifestyle factors prior to cases’ dates of diagnosis. Results: Our results showed an increased risk of ALS for subjects chronically exposed to raw water use (odds ratio (OR) = 6.55, 95% confidence interval (CI): 2.24–19.12). Garden activities showed a tight association with ALS as well, very likely as a consequence of chronic raw water exposure. Indeed, we could exclude an impact for pesticides, as no significant differences were observed in pesticide exposure in the two groups interviewed. However, cases were more often exposed to fertilizers. After adjustment for age, sex, and heavy physical activities, exposure to raw water was still associated with increased ALS risk (OR = 4.74, 95% CI: 1.33–16.85). Discussion: These findings suggest an association between ALS and exposure to raw water, which should be further investigated for the presence of chemicals interfering with nervous system functionality.

scholarly journals Occupation and subcategories of asthma: a population-based incident case–control study

2021 ◽  
pp. oemed-2020-106953
Author(s):  
Maritta S Jaakkola ◽  
Taina K Lajunen ◽  
Behzad Heibati ◽  
Ying-Chuan Wang ◽  
Ching-Huang Lai ◽  
...  
Keyword(s):  
Case Control Study ◽  
Occupational Exposures ◽  
Population Based ◽  
Case Control ◽  
Atopic Asthma ◽  
Adult Onset ◽  
Occupational Groups ◽  
Hospital District ◽  
Increased Risk ◽  
Control Study

BackgroundWe hypothesised that occupational exposures differently affect subtypes of adult-onset asthma.ObjectiveWe investigated potential relations between occupation and three subtypes of adult asthma, namely atopic asthma, non-atopic asthma and asthma–COPD overlap syndrome (ACOS).MethodsThis is a population-based case–control study of incident asthma among working-age adults living in Pirkanmaa Hospital District in Southern Finland. The determinant of interest was occupation at the time of diagnosis of asthma or the job that the subject had quit due to respiratory symptoms. Asthma was divided into three mutually exclusive subtypes on the basis of any positive IgE antibody (atopic and non-atopic asthma) and presence of persistent airways obstruction in spirometry (ACOS). We applied unconditional logistic regression analysis to estimate adjusted OR (aOR), taking into account gender, age and smoking.ResultsThe following occupational groups showed significantly increased risk of atopic asthma: chemical industry workers (aOR 15.76, 95% CI 2.64 to 94.12), bakers and food processors (aOR 4.69, 95% CI 1.18 to 18.69), waiters (aOR 4.67, 95% CI 1.40 to 15.56) and those unemployed (aOR 3.06, 95% CI 1.52 to 6.17). The following occupations showed clearly increased risk of non-atopic asthma: metal workers (aOR 8.37, 95% CI 3.77 to 18.59) and farmers and other agricultural workers (aOR 2.36, 95% CI 1.10 to 5.06). Some occupational groups showed statistically significantly increased OR of ACOS: electrical and electronic production workers (aOR 30.6, 95% CI 6.10 to 153.35), fur and leather workers (aOR 16.41, 95% CI 1.25 to 215.85) and those retired (aOR 5.55, 95% CI 1.63 to 18.97).ConclusionsOur results show that different occupations are associated with different subtypes of adult-onset asthma.

scholarly journals IS RADIOGRAPHIC LUMBAR SPONDYLOLISTHESIS ASSOCIATED WITH OCCUPATIONAL EXPOSURES? FINDINGS FROM A NESTED CASE CONTROL STUDY WITHIN THE WAKAYAMA SPINE STUDY

2019 ◽  
Author(s):  
Yuyu Ishimoto ◽  
Cyrus Cooper ◽  
Georgia Ntani ◽  
Hiroshi Yamada ◽  
Hiroshi Hashizume ◽  
...  
Keyword(s):  
Case Control Study ◽  
Occupational Exposures ◽  
Case Control ◽  
X Rays ◽  
Cross Sectional ◽  
Increased Risk ◽  
Total Data ◽  
Lumbar Spondylolisthesis ◽  
Nested Case Control ◽  
Control Study

Abstract Objective To explore the relationship between radiographic spondylolisthesis and occupational factors in a case-control study nested within the Wakayama Spine Study (WSS). Design The WSS is a cross-sectional observational study amongst Japanese adults. All participants completed a lifetime occupational history and underwent X-rays of the lumbar spine (L1-S1) according to a pre-defined protocol. One trained surgeon graded the presence of a spondylolisthesis based upon ≥5% anterior or posterior slip at one or more levels. Cases, with lumbar spondylolisthesis, were compared with controls without, for their principal occupation and occupational exposures. Results In total, data were available for 722 adults (245 men and 477 women), mean age 70.1 (range 53-93) years. According to the pre-defined radiographic criteria, 117 were defined with spondylolisthesis (cases), leaving 605 controls. Cases were not significantly different from controls for age, gender, BMI, smoking or alcohol intake. However, occupational driving ≥ 2hours/day was associated with a doubling of the risk of being a case (OR 2.39, 95% CI 1.08-5.27) after adjustment for age, gender and BMI. Additionally, after stratification by age using 75 years as a cut-point, working in the agricultural/ fishing industries was associated with a greater than 3-fold increased risk of spondylolisthesis (OR 3.47, 95% CI 1.29-9.29) among those aged <75 years. Climbing slopes/steps and walking were associated with reduced odds ratios. Conclusions A history of occupational driving and working in the agricultural/fishing industry were associated with radiographic spondylolisthesis in this cross-sectional population study. This finding requires further evaluation in longitudinal studies.

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