Neurological complications of breast cancer: study protocol of a prospective cohort study

IntroductionThe improvement in breast cancer survival rates, along with the expected overdiagnosis and overtreatment associated with breast cancer screening, requires a comprehensive assessment of its burden. Neurological complications can have a devastating impact on these patients; neuropathic pain and chemotherapy-induced peripheral neuropathy are among the most frequently reported. This project aims to understand the burden of neurological complications of breast cancer treatment in Northern Portugal, and their role as mediator of the impact of the treatment in different dimensions of the patients’ quality of life.Methods and analysisA prospective cohort study was designed to include 500 patients with breast cancer, to be followed for 3 years. The patients were recruited at the Portuguese Oncology Institute of Porto and evaluations were planned at different stages: pretreatment, after surgery, after chemotherapy (whenever applicable) and at 1 and 3 years after enrolment. Patients diagnosed with neuropathic pain or chemotherapy-induced peripheral neuropathy (subcohorts), were also evaluated at the moment of confirmation of clinical diagnosis of the neurological complication and 6 months later. In each of the follow-up periods, a neurological examination has been performed by a neurologist. Data were collected on sociodemographic and clinical characteristics, quality of life, sleep quality, and anxiety and depression. Between January and December 2012, we recruited and conducted the baseline evaluation of 506 participants. The end of the follow-up period is scheduled for December 2015.Ethics and disseminationThe study protocol was approved by the Ethics Committee of the Portuguese Oncology Institute of Porto and all patients provided written informed consent. All study procedures were developed in order to assure data protection and confidentiality. Results from this project will be disseminated in international peer-reviewed journals and presented in relevant conferences.

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Study protocol for resolution of organ injury in acute pancreatitis (RESORP): an observational prospective cohort study

BMJ Open ◽

10.1136/bmjopen-2020-040200 ◽

2020 ◽

Vol 10 (12) ◽

pp. e040200

Author(s):

Ahmed E Sherif ◽

Rory McFadyen ◽

Julia Boyd ◽

Chiara Ventre ◽

Margaret Glenwright ◽

...

Keyword(s):

Quality Of Life ◽

Diabetes Mellitus ◽

Acute Pancreatitis ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Observational Prospective Cohort Study ◽

New Onset

IntroductionSurvivors of acute pancreatitis (AP) have shorter overall survival and increased incidence of new-onset cardiovascular, respiratory, liver and renal disease, diabetes mellitus and cancer compared with the general population, but the mechanisms that explain this are yet to be elucidated. Our aim is to characterise the precise nature and extent of organ dysfunction following an episode of AP.Methods and analysisThis is an observational prospective cohort study in a single centre comprising a University hospital with an acute and emergency receiving unit and clinical research facility. Participants will be adult patient admitted with AP. Participants will undergo assessment at recruitment, 3 months and 3 years. At each time point, multiple biochemical and/or physiological assessments to measure cardiovascular, respiratory, liver, renal and cognitive function, diabetes mellitus and quality of life. Recruitment was from 30 November 2017 to 31 May 2020; last follow-up measurements is due on 31 May 2023. The primary outcome measure is the incidence of new-onset type 3c diabetes mellitus during follow-up. Secondary outcome measures include: quality of life analyses (SF-36, Gastrointestinal Quality of Life Index); montreal cognitive assessment; organ system physiological performance; multiomics predictors of AP severity, detection of premature cellular senescence. In a nested cohort within the main cohort, individuals may also consent to multiparameter MRI scan, echocardiography, pulmonary function testing, cardiopulmonary exercise testing and pulse-wave analysis.Ethics and disseminationThis study has received the following approvals: UK IRAS Number 178615; South-east Scotland Research Ethics Committee number 16/SS/0065. Results will be made available to AP survivors, caregivers, funders and other researchers. Publications will be open-access.Trial registration numbersClinicalTrials.gov Registry (NCT03342716) and ISRCTN50581876; Pre-results.

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Prospective cohort study assessing limb volume change (LVC) and quality of life in breast cancer survivors

Journal of Clinical Oncology ◽

10.1200/jco.2008.26.15_suppl.9561 ◽

2008 ◽

Vol 26 (15_suppl) ◽

pp. 9561-9561

Author(s):

J. N. Cormier ◽

Y. Xing ◽

I. Zaniletti ◽

R. L. Askew ◽

B. R. Stewart ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Cohort Study ◽

Cancer Survivors ◽

Prospective Cohort Study ◽

Volume Change ◽

Prospective Cohort ◽

Breast Cancer Survivors ◽

Limb Volume

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Chemotherapy-induced amenorrhea, menopause-specific quality of life, and endocrine profiles in premenopausal women with breast cancer who received adjuvant anthracycline-based chemotherapy: a prospective cohort study

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-013-2227-5 ◽

2013 ◽

Vol 72 (3) ◽

pp. 565-575 ◽

Cited By ~ 23

Author(s):

Changhoon Yoo ◽

Mi Ra Yun ◽

Jin-Hee Ahn ◽

Kyung Hae Jung ◽

Hwa Jung Kim ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Premenopausal Women ◽

Endocrine Profiles

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The Impact of Radiodermatitis on Breast Cancer Patients' Quality of Life During Radiotherapy: A Prospective Cohort Study

Journal of Pain and Symptom Management ◽

10.1016/j.jpainsymman.2019.03.017 ◽

2019 ◽

Vol 58 (1) ◽

pp. 92-99.e1 ◽

Cited By ~ 2

Author(s):

Marceila de Andrade Fuzissaki ◽

Carlos Eduardo Paiva ◽

Marco Antonio de Oliveira ◽

Paula Philbert Lajolo Canto ◽

Yara Cristina de Paiva Maia

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Cohort Study ◽

Cancer Patients ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Breast Cancer Patients ◽

The Impact

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Comparison of Life Quality in Patients Undergoing Open Vein Harvesting and Endoscopic Vein Harvesting Techniques: A Prospective Cohort Study

Shiraz E-Medical Journal ◽

10.5812/semj.102169 ◽

2020 ◽

Vol In Press (In Press) ◽

Author(s):

Ahmad Amouzeshi ◽

Bibi Fatemeh Shakhsemampour ◽

Somaye Jomefourjan ◽

Reyhaneh Panahi ◽

Zahra Amouzeshi

Keyword(s):

Quality Of Life ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Life Quality ◽

Sufficient Information ◽

Endoscopic Vein Harvesting ◽

Vein Harvesting

Background: As the traditional indicators of the operative outcomes, including morbidity and mortality, cannot give sufficient information on a patient’s physical, mental, emotional, and functional well-being alone, we aimed to compare life quality in the patients under open vein harvesting (OVH) and endoscopic vein harvesting (EVH) techniques after four years of follow-up. Methods: This prospective cohort study followed all the patients who were scheduled for off-pump CABG in the Mashhad-based Imam Reza Hospital, in October 2013, for 4 years. Accordingly, data related to their quality of life were collected, and their life quality was then compared using the WHOQOL-BREF scale. T-test and relative risk were also used. Results: This study was conducted on a total of 103 patients under the two techniques of OVH (n = 53) and EVH (n = 50). The difference between the EVH (4.7%) and OVH (16.3%) groups at the demographic characteristics was the Transient Ischemic Attack (P = 0.023). After a 4-years follow-up period, no significant differences were observed between the patients undergoing the two techniques of OVH and EVH in all the domains of life quality. Conclusions: According to the obtained results, there was no difference in the quality of life between the patients undergoing OVH and EVH techniques over a four-year period. In this regard, further investigations are recommended on the quality of life in patients under the two techniques of OVH and EVH with long-term follow-up periods.

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Older People's Quality of Life (OPQOL) scores and adverse health outcomes at a one-year follow-up. A prospective cohort study on older outpatients living in the community in Italy

Health and Quality of Life Outcomes ◽

10.1186/1477-7525-9-72 ◽

2011 ◽

Vol 9 (1) ◽

pp. 72 ◽

Cited By ~ 49

Author(s):

Claudio Bilotta ◽

Ann Bowling ◽

Paola Nicolini ◽

Alessandra Casè ◽

Gloria Pina ◽

...

Keyword(s):

Quality Of Life ◽

Cohort Study ◽

Health Outcomes ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Adverse Health ◽

Adverse Health Outcomes ◽

One Year

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Informed, Patient-Centered Decisions Associated with Better Health Outcomes in Orthopedics: Prospective Cohort Study

Medical Decision Making ◽

10.1177/0272989x18801308 ◽

2018 ◽

Vol 38 (8) ◽

pp. 1018-1026 ◽

Cited By ~ 20

Author(s):

Karen R. Sepucha ◽

Steven J. Atlas ◽

Yuchiao Chang ◽

Andrew Freiberg ◽

Henrik Malchau ◽

...

Keyword(s):

Quality Of Life ◽

Cohort Study ◽

Health Outcomes ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Herniated Disc ◽

Patient Centered ◽

Informed Patient

Background. A goal of shared decision making (SDM) is to ensure patients are well informed and receive preferred treatments. However, the relationship between SDM and health outcomes is not clear. Objective. The purpose was to examine whether patients who are well informed and receive their preferred treatment have better health outcomes. Design, Setting, and Participants. A prospective cohort study at an academic medical center surveyed new patients with knee or hip osteoarthritis, herniated disc, or spinal stenosis 1 week after seeing a specialist and again 6 months later. Main Outcomes and Measures. The survey assessed knowledge, preferred treatment, and quality of life (QoL). The percentage of patients who were well informed and received preferred treatment was calculated (informed, patient centered [IPC]). A follow-up survey assessed QoL, decision regret, and satisfaction. Regression analyses with generalized estimating equations to account for clustering tested a priori hypotheses that patients who made IPC decisions would have higher QoL.Results. Response rate was 70.3% (652/926) for initial and 85% (551/648) for follow-up. The sample was 63.9 years old, 52.8% were female, 62.6% were college educated, and 49% had surgery. One-third (37.4%) made IPC decisions. Participants who made IPC decisions had significantly better overall (0.05 points (SE 0.02) for EQ-5D, P = 0.004) and disease-specific quality of life (4.22 points [SE 1.82] for knee, P = 0.02; 4.46 points [SE 1.54] for hip, P = 0.004; and 6.01 points [SE 1.51] for back, P < 0.0001), higher satisfaction and less regret. Limitations. Observational study at a single academic center with limited diversity. Conclusions. Well-informed patients who receive their preferred treatment also had better health outcomes and higher satisfaction.

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